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Complex model of molecular ‘wear-and-tear’ shines light on how proteins age

Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.

Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.

Proteins, much like the rest of the body, change when aging. This is especially the case for the that make up , which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring to the protein called post-translational modifications, or PTMs.

Test of ‘Poisoned Dataset’ shows Vulnerability of LLMs to Medical Misinformation

For their study published in the journal Nature Medicine, the group generated thousands of articles containing misinformation and inserted them into an AI training dataset and conducted general LLM queries to see how often the misinformation appeared.

Prior research and anecdotal evidence have shown that the answers given by LLMs such as ChatGPT are not always correct and, in fact, are sometimes wildly off-base. Prior research has also shown that misinformation planted intentionally on well-known internet sites can show up in generalized chatbot queries. In this new study, the research team wanted to know how easy or difficult it might be for malignant actors to poison LLM responses.

10 Bold Biotech Predictions That Will Shock You

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Artificial Wombs Are on the Verge of Human Trials. SEE to believe!

This week, The Circuit explores the cutting-edge technology of artificial wombs! Discover how engineers and scientists are working to save premature babies and even endangered species.
In this episode, we look at:

• The development of artificial womb technology for human preemie babies.
• How the Okinawa Churaumi Aquarium is using artificial wombs to save.
shark embryos.
• How bioengineers were able to grow a premature lamb in a biobag.

Artificial wombs represent a fascinating intersection of biology and engineering.

What are YOUR thoughts on the artificial womb? Amazing or frightening?

#ArtificialWomb #Preemies #SharkConservation #Biology #Engineering #NeonatalCare #MedTech #TheCircuit #Pregnancy #Doctors #Hospital #Healthcare

Could Light Therapy Be the Key to Easing Alzheimer’s Symptoms?

Light therapy is emerging as a promising, non-pharmacological treatment for Alzheimer’s.

Alzheimer’s disease is a progressive neurological disorder that primarily affects older adults, leading to memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia. The disease is characterized by the buildup of amyloid plaques and tau tangles in the brain, which disrupt cell function and communication. There is currently no cure, and treatments focus on managing symptoms and improving quality of life.

Turning Off Anxiety: Scientists Discover the Brain’s Hidden Switch

Using light-sensitive drugs, they identified a promising neural pathway that could lead to more effective, safer anxiety treatments.

Targeting Anxiety with Brain Circuit Research

Researchers at Weill Cornell Medicine have identified a specific brain circuit that, when inhibited, reduces anxiety without causing noticeable side effects — at least in preclinical models. Their findings highlight a potential new target for treating anxiety disorders and introduce a broader strategy for studying drug effects in the brain using a technique called photopharmacology.