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Category: biotech/medical – Page 2,396

Magnets shown to create more power in electrical generators

Electric generators have a plethora of uses—ranging from automotive to aircraft to microgrids. There is currently a strong desire to reduce the size and increase the efficiency of the devices.

Researchers at Purdue University have come up with an effective way to reduce the size and increase the efficiency of the moderate- to low-power electric generators used in those applications.

A wound rotor synchronous machine contains a field winding—a group of insulated current-carrying coils—on the rotor used to create a rotating and regulate the output voltage. Associated with this winding are losses, which generate heat that must be removed from the spinning rotor. Permanent magnets can also be used to generate the magnetic field with much less loss and heat generation, but this approach does not facilitate output voltage regulation.

Dr. Steffanie Strathdee PhD. — UCSD Center for Innovative Phage Applications and Therapeutics (IPATH) — ideaXme — Ira Pastor

Researchers develop promising reconstruction method based on 3D-printed esophageal grafts

The loss of complete segments of the esophagus often results from treatments for esophageal cancer or congenital abnormalities, and current methods to re-establish continuity are inadequate. Now, working with a rat model, researchers have developed a promising reconstruction method based on the use of 3D-printed esophageal grafts. Their work is published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Eun-Jae Chung, MD, PhD, Seoul National University Hospital, Korea, Jung-Woog Shin, PhD, Inje University, Korea, and colleagues present their research in an article titled “Tissue-Engineered Esophagus via Bioreactor Cultivation for Circumferential Esophageal Reconstruction”. The authors created a two-layered tubular scaffold with an electrospun nanofiber inner layer and 3D-printed strands in the outer layer. After seeding human mesenchymal stem cells on the inner layer, constructs were cultured in a bioreactor, and a new surgical technique was used for implantation, including the placement of a thyroid gland flap over the scaffold. Efficacy was compared with omentum-cultured scaffolding technology, and successful implantation and esophageal reconstruction were achieved based on several metrics.

Dr. Chung and colleagues from Korea present an exciting approach for esophageal repair using a combined 3D printing and bioreactor cultivation strategy. Critically, their work shows integration of the engineered esophageal tissue with host tissue, indicating a clinically viable strategy for circumferential esophageal reconstruction.”

Episode two of this series explores the dawn of the era of a science-based search for truth, in particular, the study of life and the microscopic cells that form our bodies

Click on photo to start video.

With that basic research, mankind found the first major clue to the origins of aging and death. They discovered that some cells in our bodies that may never die. These “immortal cells” and the philosophical shift in thinking they engendered, will likely change medicine as we know it.

Neutral evolution shapes lifespan and aging

Different African killifish species vary extensively in their lifespans—from just a few months to several years. Scientists from the Max Planck Institute for Biology of Ageing in Cologne investigated how different lifespans have evolved in nature and discovered a fundamental mechanism by which detrimental mutations accumulate in the genome causing fish to age fast and become short-lived. In humans, mutations accumulate mainly in the genes that are active in old age.

Cancer cell’s “self eating” tactic may be its weakness

Cold Spring Harbor, NY — Cancer cells use a bizarre strategy to reproduce in a tumor’s low-energy environment; they mutilate their own mitochondria! Researchers at Cold Spring Harbor Laboratory (CSHL) also know how this occurs, offering a promising new target for pancreatic cancer therapies.

Why would a cancer cell want to destroy its own functioning mitochondria? “It may seem pretty counterintuitive,” admits M.D.-Ph. D. student Brinda Alagesan, a member of Dr. David Tuveson’s lab at CSHL.

According to Alagesan, the easiest way to think about why cancer cells may do this is to think of the mitochondria as a powerplant. “The mitochondria is the powerhouse of the cell,” she recites, recalling the common grade school lesson. And just like a traditional powerplant, the mitochondria create their own pollution.