This gives credence to the 5–2 diet, which has recently gained in popularity thanks to a large celebrity following.
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Category: biotech/medical – Page 2,385
Growing Brains in Lab
Posted in biotech/medical, neuroscience
Scientists create 3-dimensional brain spheroids—small, spherical, laboratory-grown human brain tissue.
- By Sam Rose on September 25, 2018
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A recent open-access mouse study published by Xi’an Institute of Tissue Engineering and Regenerative Medicine scientists in the journal Bone Research describes how the ALPL gene affects bone aging and suggests that metformin might constitute a viable therapeutic option to prevent it [1].
Study abstract
Mutations in the liver/bone/kidney alkaline phosphatase (Alpl) gene cause hypophosphatasia (HPP) and early-onset bone dysplasia, suggesting that this gene is a key factor in human bone development. However, how and where Alpl acts in bone ageing is largely unknown. Here, we determined that ablation of Alpl induces prototypical premature bone ageing characteristics, including bone mass loss and marrow fat gain coupled with elevated expression of p16INK4A (p16) and p53 due to senescence and impaired differentiation in mesenchymal stem cells (MSCs). Mechanistically, Alpl deficiency in MSCs enhances ATP release and reduces ATP hydrolysis. Then, the excessive extracellular ATP is, in turn, internalized by MSCs and causes an elevation in the intracellular ATP level, which consequently inactivates the AMPKα pathway and contributes to the cell fate switch of MSCs.
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The new digital communications policy (NDCP) 2018, approved by the Cabinet on Wednesday, looks too good to believe. It has promised to create an additional four million jobs in five years and reskill another one million people in new-age skills and sectors such as 5G LTE and artificial intelligence. Six lakh villages will be connected which will eventually lead to creating jobs and several earning avenues such as managing WiFi hotspots and laying optical fibre, among others. The policy will give an impetus to the job market.
NDCP is bound to create a massive infrastructure and help the debt-ridden telecom sector emerge from its current turbulence. The policy document envisages the reduction in levies and ease of doing business, and this will help restore the financial health of the long-bleeding sector. The focus will be on the proliferation of telecom services and facilitating low-cost financing. The government’s ambitious plan of Digital India will get a booster shot. Thanks to the promise of 50 Mbps speed in the broadband connection, the consumer will be the ultimate beneficiary.
Plans are afoot to reform the licensing and regulatory regime to facilitate investments and innovation, besides promoting ease of doing business. The success of the policy will depend on the execution of the policy.
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A study from the UNC School of Medicine showed that the protein NLRP12, known for its anti-inflammatory effects, also protects mice on a high-fat diet against obesity and insulin resistance; it might have a similar effect in humans [1].
Study abstract
In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation and are important for resolving inflammation, but their role in obesity is unknown. We show that obesity in humans correlates with reduced expression of adipose tissue NLRP12. Similarly, Nlrp12/ mice show increased weight gain, adipose deposition, blood glucose, NF-kB/ MAPK activation, and M1-macrophage polarization. Additionally, NLRP12 is required to mitigate HFD-induced inflammasome activation. Co-housing with wild-type animals, antibiotic treatment, or germ-free condition was sufficient to restrain inflammation, obesity, and insulin tolerance in Nlrp12/ mice, implicating the microbiota. HFD-fed Nlrp12/ mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced Lachnospiraceae family and the associated enzymes required for short-chain fatty acid (SCFA) synthesis.
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That conclusion is based on a study that reviewed genetic testing results from 1.45 million individuals and found that nearly 25 percent of “variants of uncertain significance” were subsequently reclassified — sometimes as less likely to be associated with cancer, sometimes as more likely.
The study appears in the Journal of the American Medical Association (JAMA).
When variations from the norm are discovered in a gene, the variants are classified as “benign,” “likely benign,” “variant of uncertain significance,” “likely pathogenic,” or “pathogenic.”
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Certainly, there are those in the movement who espouse the most extreme virtues of transhumanism such as replacing perfectly healthy body parts with artificial limbs. But medical ethicists raise this and other issues as the reason why transhumanism is so dangerous to humans when what is considered acceptable life-enhancement has virtually no checks and balances over who gets a say when we “go too far.” For instance, Kevin Warwick of Coventry University, a cybernetics expert, asked the Guardian, “What is wrong with replacing imperfect bits of your body with artificial parts that will allow you to perform better – or which might allow you to live longer?” while another doctor stated that he would have “no part” in such surgeries. There is, after all, a difference between placing a pacemaker or performing laser eye surgery on the body to prolong human life and lend a greater degree of quality to human life, and that of treating the human body as a tabula rasa upon which to rewrite what is, effectively, the natural course of human life.
While many https://whatistranshumanism.org/#what-is-a-transhuman” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://whatistranshumanism.org/#what-is-a-transhuman”> transhumanist ideals remain purely theoretical in scope, what is clear is that females are the class of humans who are being theorised out of social and political discourse. Indeed, much of the social philosophy surrounding transhumanist projects sets out to eliminate gender in the human species through the application of advanced biotechnology and assisted reproductive technologies, ultimately inspired by Shulamith Firestone’s https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://teoriaevolutiva.files.wordpress.com/2013/10/fireston…lution.pdf”> The Dialectic of Sex and much of Donna Haraway’s writing on https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf” target=”_blank” rel=” nofollow noopener noreferrer” data-ga-track=” ExternalLink: https://warwick.ac.uk/fac/arts/english/currentstudents/under…sm_in_the_…pdf”> cyborgs. From parthenogenesis to the creation of artificial wombs, this movement seeks to remove the specificity of not gender, but sex, through the elision of medical terminology and procedures which portend to advance a technological human-cyborg built on the ideals of a post-sex model.
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Highly specialized cartilage is characteristically avascular and non-neural in composition with low cell numbers in an aliphatic environment. Despite its apparent simplicity, bioengineering regenerative hyaline cartilage in a form effective for implantation remains challenging in musculoskeletal tissue engineering. Existing surgical techniques including autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are considered superior to self-repair induction techniques. However, both MACI and ACI are complex, multistage procedures that require a double operation; first for surgical excision of native cartilage, followed by expansion of adult chondrocytes in vitro prior to implantation by a second operation.
Regenerating robust articular hyaline-like cartilage is a key priority in musculoskeletal tissue engineering to prevent cost-intensive degenerative osteoarthritis that limits the quality of life in global healthcare. Integrating mesenchymal stem cells and 3D printing technologies has shown significant promise in bone tissue engineering– although the key challenge remains in transferring the bench-based technology to the operating room for real-time applications. To tackle this, a team of Australian orthopedic surgeons and bioengineers collaboratively proposed an in situ additive manufacturing technique for effective cartilage regeneration. The handheld engineered extrusion device known as the BioPen offers an advanced, co-axial extrusion strategy to deposit cells embedded in a hydrogel material within a surgical setting.
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Today, we have an interview with Dr. Michael Bonkowski, an expert on NAD+ biology and aging from the David Sinclair Lab, Harvard Medical School.
Michael Bonkowski aims to advance our understanding of the links between metabolism, aging, and age-associated diseases. He has published 35 peer-reviewed journal articles and has conducted multiple successful longevity studies. In Dr. David Sinclair’s lab, his research efforts are focused on the role of nutrient sensors’ regulation of endocrine signaling and aging in the mouse. He is also working on direct and indirect ways to drive the activity of these nutrient sensors by using dietary manipulations, small molecules, and chemical treatments.
Michael is trained as a pharmacologist, physiologist, and animal scientist. Some of his areas of expertise include animal physiology, genetics, glucose, and insulin homeostasis, metabolism, assay development, protein biochemistry, and transmission electron microscopy imaging.
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