Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 238

Cell biologists discover two proteins are key to proper transfer of genetic material

The biological research of UC Santa Cruz’s Needhi Bhalla to determine the molecular motions at the heart of heredity has yielded a new discovery: The proper transfer of genetic materials depends on two key proteins that choreograph the delicate dance between chromosomes when sexual-reproduction cells divide.

When cells split to create eggs and sperm, they must undergo a crucial process called “meiotic crossover recombination.” This mechanism ensures that is properly shuffled between chromosomes, preventing errors that could lead to disorders such as miscarriages, infertility, birth defects, and even cancer.

This process also results in the endearing transfer of traits that parents see in their children. And beyond contributing to parental pride, Bhalla says meiotic crossover recombination is fundamental for human evolution by promoting . That’s why the identification of two specific proteins that play central roles in controlling how and where these crossovers happen is so significant.

Scientists Discover Unexpected Link Between Diet And Lung Cancer Risk

Most of us would probably think of smoking or air pollution when it comes to lung cancer risk, but researchers have discovered an intriguing link between the disease and the quality of our diets.

The researchers, from the University of Florida and the University of Kentucky, found that the molecule glycogen, which stores the simple sugar glucose, could potentially act as a driver of some types of lung cancer.

Glycogen was found at higher levels in human tissue samples of lung adenocarcinoma, the type responsible for 40 percent of lung cancers worldwide. In tests on mice, the team found that more glycogen helped lung cancers to grow faster, while taking the molecule away led to restricted tumor growth.

Which Biomarkers Are Associated With Cancer Cachexia?

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs): https://www.ultalabtests.com/partners/michaellustgarten.

At-Home Metabolomics: https://www.iollo.com?ref=michael-lustgarten.
Use Code: CONQUERAGING At Checkout.

Clearly Filtered Water Filter: https://get.aspr.app/SHoPY

Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQdQ6…M0&irgwc=1
Use Code: CONQUERAGING

NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/

Continue reading “Which Biomarkers Are Associated With Cancer Cachexia?” | >

Scientists propose a targeted lysosomal dysfunction approach for glioblastoma treatment

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the targeted suppression of lysosome function may lead to brain cancer therapy.

Glioblastoma is a type of brain cancer with a very poor prognosis of survival. Causes of are not known, and there is no method for preventing the cancer. Traditional treatment includes the drug temozolomide (TMZ). In many cases, TMZ kills glioblastoma cells, but a significant portion of patients show resistance to the drug.

Changes in the levels of metabolites— playing key roles in metabolic processes in living organisms—have been observed in TMZ-resistant glioblastoma cells, pointing to the importance of understanding and targeting metabolic pathways in the context of cancer therapy.

Cancer cells mimic Sherpa genes to survive low oxygen

Results of a study show convergent genetic adaptation under hypoxia (lack of oxygen) between populations living at high-altitude in the Himalayan region such as Tibetans and Sherpas, and the development of oxygen-starved cancer cells. The study was directed by Rodrigo Toledo, Head of the Vall d’Hebron Institute of Oncology’s (VHIO) Biomarkers and Clonal Dynamics Group and published in the journal Cancer Discovery.

Patients with cyanotic congenital heart disease (CCHD) are chronically hypoxic and have an estimated six-fold higher risk of developing pheochromocytoma and paraganglioma (PPGL), which are associated with (NETs) of the adrenal glands and/or paraganglia, respectively. These cancers can continue to grow and proliferate under chronic hypoxia.

“With this study, we aimed to achieve deeper insights into how tumors can survive, grow, and even metastasize under low oxygen conditions, known as hypoxia. Our findings reveal a broad convergence in in tumors that continue to develop and grow under hypoxia, and in high-altitude populations who thrive in such a challenging environment,” said Toledo, corresponding author of this present article.

/* */