Going to a clinic for a vaccine shot may no longer be necessary with this technology that’s now in development.
South China Morning Post February 19, 2019.
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Category: biotech/medical – Page 2274
Killing ticks and inoculating people has failed, so researchers try immunizing mice via vaccine-laced food.
- By Angus Chen on January 29, 2019
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Valneva SE announced final Phase 1 study data and positive initial booster data for its Lyme Disease vaccine candidate VLA15.
“The positive final Phase 1 data for VLA15 supports and validates our plans to continue developing a safe and effective preventative vaccine that can be delivered to those who are at risk of Lyme disease infection,” said Thomas Lingelbach, CEO of Valneva.
“We look forward to continuing the development process with our recently initiated Phase 2 study. We continue to fully commit ourselves to addressing the significant unmet need for a vaccine against Lyme disease.”
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Advancing therapy
Posted in biotech/medical
Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow cancer progression. While mutations in cancer cells significantly affect drug sensitivity, it is increasingly recognized that ecological interactions between cells can also play a role.
Jacob Scott, MD, DPhil, a physician-scientist at Cleveland Clinic, is interested in learning how cancer cells develop and maintain drug resistance from an eco-evolutionary perspective. He studies the evolutionary strategies that cells employ to survive even in the harshest of conditions. One area of focus of his laboratory is to examine the dynamics of sensitive versus resistant cancer cells and how they affect one another’s growth under the selective pressure of anti-cancer therapies.
“Rather than searching for a ‘silver bullet’ to wipe out all resistant cells, which is unlikely, we are focused on preventing the resistant cells from taking over—from ‘winning’ every time,” Dr. Scott said. “If we can achieve this goal, we can effectively make cancer a chronic condition.”
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Researchers have shown that a type of magnetic resonance imaging—called neuromelanin-sensitive MRI (NM-MRI)—is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in the Proceedings of the National Academy of Science.
“Disturbances affecting the neurotransmitter dopamine are associated with a host of mental and neurological disorders, such as schizophrenia and Parkinson’s disease,” said Joshua A. Gordon, M.D., Ph.D., director of NIMH. “Because of the role dopamine plays in these disorders, the ability to measure dopamine activity is critical for furthering our understanding of these disorders, including how to best diagnose and treat them.”
Neuromelanin is a dark pigment created within dopamine neurons of the midbrain—particularly in the substantia nigra, a brain area that plays a role in reward and movement. Neuromelanin accumulates over the lifespan and is only cleared away from cells following cell death, as occurs in neurodegenerative disorders such as Parkinson’s disease. Researchers have found that NM-MRI signal is lower in the substantia nigra of people with Parkinson’s disease, reflecting the cell death that occurs in these patients.
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A British woman has become the first person in the world to undergo gene therapy for the most common cause of sight loss.
Surgeons at the John Radcliffe Hospital in Oxford inserted a synthetic gene into the left eye of Janet Osborne, 80, who suffers from age-related macular degeneration (AMD).
Around 600,000 people in the UK are affected by AMD, which affects the central part of a patient’s vision with gaps or ‘smudges’, making everyday activities like reading and recognising faces difficult.
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Summary: Researchers have identified a previously unknown form of neural communication. They report the findings could help better the understanding of neural activity associated with specific brain processing and neurological disorders.
Source: Case Western Reserve University.
Biomedical engineering researchers at Case Western Reserve University say they have identified a previously unidentified form of neural communication, a discovery that could help scientists better understand neural activity surrounding specific brain processes and brain disorders.
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Liz talking about Rutgers, Integrated Health Systems, anti-aging vaccine(couple of years of gathering data), $75,000 single organ treatment, and potential for very affordable whole body treatment. Q&A at 32 minutes.
Liz Parrish | BioViva, presents at People Unlimited’s Ageless Education, about Gene Therapy Advancements.
The Ageless Education series brings in many of the leading figures in radical life extension to share their views on the most cutting edge strategies for living long enough to live forever.