Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 2,239

Researchers identify how to prevent cancer metastases

The published results indicate several possible methods of preventing metastasis: immunotherapy based on interleukin-15, which increases the number of natural killer cells in the tissue; interferon gamma therapy, which maintains the dormant state of the cancer cells; and inhibitors of the mechanism through which the hepatic stellate cells paralyze the natural killer cells. Appropriate therapies already exist for all these approaches, but they still need to be clinically tested.

Metastases can develop in the body even years after apparently successful cancer treatment. They originate from cancer cells that migrated from the original tumor to other organs, and which can lie there inactive for a considerable time. Researchers have now discovered how these “sleeping cells” are kept dormant and how they wake up and form fatal metastases. They have reported their findings in the journal Nature.

A tumor can leave behind an ominous legacy in the body: cancer cells can migrate from the tumor to other tissues in the body, where they survive after treatment in a kind of hibernation called dormancy. Currently, cancer medicine relies on monitoring after their initial treatment in order to detect the awakening of these cells to form metastases. One of the biggest questions in cancer research is what exactly causes this transition.

“This dormancy period offers an important therapeutic window in which the number of cancer cells and their heterogeneity are still manageable,” says Professor Mohamed Bentires-Alj, group leader at the Department of Biomedicine at the University of Basel and University Hospital Basel. “Understanding the cellular and underlying tumor dormancy is therefore crucial to preventing the recurrence of cancer.” His team has made an important step in this direction.

Revolutionary Self-Aware Materials Build the Foundation for Living Structures

New research in Nano Energy introduces revolutionary scalable material that senses and powers itself.

From the biggest bridges to the smallest medical implants, sensors are everywhere, and for good reason: The ability to sense and monitor changes before they become problems can be both cost-saving and life-saving.

To better address these potential threats, the Intelligent Structural Monitoring and Response Testing (iSMaRT) Lab at the University of Pittsburgh Swanson School of Engineering has designed a new class of materials that are both sensing mediums and nanogenerators, and are poised to revolutionize the multifunctional material technology big and small.

Researchers increase life expectancy in mice by an average of 30%

Aging is associated with an overall decline in health and increased frailty, and is a major risk factor for multiple chronic diseases. Frailty syndrome, characterized by weakness, fatigue and low physical activity, affects more than 30% of the elderly population. Increasing our understanding of the mechanisms underlying the aging process is a top priority to facilitate the development of interventions that will lead to the preservation of health and improvements on survival and lifespan.

Cumulative evidence suggests that diet and metabolism are key targetable regulators of healthy lifespan. Prof. Haim Cohen, Director of the Sagol Healthy Human Longevity Center at Bar-Ilan University, focuses much of his research on the SIRT6 protein that is involved in regulating many biological processes, such as aging, obesity, and insulin resistance.

In a study just published in the journal Nature Communications, an international team led by Cohen and his Ph.D. student Asael Roichman—together with Prof. Rafael de Cabo, of the National Institute on Aging at the National Institutes of Health, Prof. Manuel Serrani, of the Institute for Research in Biomedicine in Barcelona, and Prof. Eyal Gottlieb from the Technion—report that express high levels of the SIRT6 gene, and show that their can be increased by an average of 30% in both males and females. Translated into human terms this means that a 90-year-old could live until nearly 120!

Synthetic SPECIES developed for use as a confinable gene drive

CRISPR-based technologies offer enormous potential to benefit human health and safety, from disease eradication to fortified food supplies. As one example, CRISPR-based gene drives, which are engineered to spread specific traits through targeted populations, are being developed to stop the transmission of devastating diseases such as malaria and dengue fever.

But many scientists and ethicists have raised concerns over the unchecked spread of gene drives. Once deployed in the wild, how can scientists prevent gene drives from uncontrollably spreading across populations like wildfire?

Now, scientists at the University of California San Diego and their colleagues have developed a gene drive with a built-in genetic barrier that is designed to keep the drive under control. Led by molecular geneticist Omar Akbari’s lab, the researchers engineered synthetic fly that, upon release in sufficient numbers, act as gene drives that can spread locally and be reversed if desired.

Evidence of Sleep-Dependent Brain Activity in Clearing Toxic Proteins and Preventing Alzheimer’s Disease

Global brain activity seen on fMRI, and its connection with cerebrospinal fluid flow weaker in brains of individuals with Alzheimer’s disease risk or related toxin buildup.

Evidence of sleep-dependent low-frequency (0.1 Hz) global brain activity in the clearance of Alzheimer’s disease-related toxin buildup is presented in research published today (June 1, 2021) in the open access journal PLOS Biology by Xiao Liu and colleagues at The Pennsylvania State University. This neuronal activity was more strongly linked with cerebrospinal fluid flow in healthy controls than higher risk groups and patients, and the findings could serve as a potential imaging marker for clinicians in evaluating patients.

The development of Alzheimer’s disease is believed to be driven by the buildup of the toxic proteins amyloid-β and tau in the brain. The brain’s glymphatic system plays a crucial role in clearing these toxins and previous work has shown a possible relationship between sleep-dependent global brain activity and the glymphatic system by showing this activity is coupled by cerebrospinal fluid flow essential for the glymphatic system.

Clinical Trial Confirms Nasal Spray Efficacy in Treating, Reducing Transmission of COVID-19

I believe I posted about Nitric Oxide as treatment for covid19 ages ago. Apparently I was right. It also works under the UK variant, thus showing it can work under others as well.

Results of clinical trials conducted in the United Kingdom have shown that a nitric oxide nasal spray (NONS, SaNOtize) is both a safe and effective antiviral treatment to prevent COVID-19 transmission and symptom duration, as well as reduce symptom severity and damage in those already infected, according to the study authors.

“NONS destroys the virus, blocks entry into and halts viral replication within the nasal cavity, which rapidly reduces viral load. This is significant because viral load has been linked to infectivity and poor outcomes,” said Chris Miller, PhD, RT, chief science officer and co-founder of SaNOtize, in a press release. “There is currently a lack of an antiviral therapy that is effective against COVID-19 and its variants, can prevent or shorten the course of the disease, reduce damage, lower the severity of COVID-19, and can be made widely and readily available to the public.”

Results of clinical trials have shown that a nitric oxide nasal spray is both a safe and effective antiviral treatment to prevent COVID-19 transmission and symptom duration, as well as reduce symptom severity and damage in those already infected.

/* */