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Category: biotech/medical – Page 2,130

$315M Biotech Company Emerges From Stealth

“Prime Editing is a wonderful example of the revolution in genetic medicine that we are living through,” said Robert Nelsen, co-founder and Managing Director of ARCH Venture Partners, one of several companies to fund Prime Medicine. “Gene editing technologies like this, when mature, could totally change our conception of what’s possible in treating disease.”

“This is an opportunity to take a giant step toward cures for a much wider range of diseases than previously possible,” said Stephen Knight, President and Managing Partner of F-Prime Capital, another backer of the new company.

The funds raised will be used to continue building the company, expand the capabilities of its technology platform and rapidly advance towards clinical indications. By the end of 2021, Prime Medicine expects to employ more than 100 people full-time.

The Paradox of a Free-Electron Laser Without the Laser: A New Source of Coherent Radiation

A new way of producing coherent light in the ultra-violet spectral region, which points the way to developing brilliant table-top x-ray sources, has been produced in research led at the University of Strathclyde.

The scientists have developed a type of ultra-short wavelength coherent light source that does not require laser action to produce coherence. Common electron-beam based light sources, known as fourth-generation light sources, are based on the free-electron laser (FEL), which uses an undulator to convert electron beam energy into X-rays.

Coherent light sources are powerful tools that enable research in many areas of medicine, biology, material sciences, chemistry, and physics.

Advanced New Artificial Intelligence Software Can Compute Protein Structures in 10 Minutes

Unlike DeepMind, the UW Medicine team’s method, which they dubbed RoseTTAFold, is freely available. Scientists from around the world are now using it to build protein models to accelerate their own research. Since July, the program has been downloaded from GitHub by over 140 independent research teams.

Accurate protein structure prediction now accessible to all.

Scientists have waited months for access to highly accurate protein structure prediction since DeepMind presented remarkable progress in this area at the 2020 Critical Assessment of Structure Prediction, or CASP14, conference. The wait is now over.

Researchers at the Institute for Protein Design at the University of Washington School of Medicine in Seattle have largely recreated the performance achieved by DeepMind on this important task. These results were published online by the journal Science on July 15, 2021.

The Virus Trap: Hollow Nano-Objects Made of DNA Could Trap Viruses and Render Them Harmless

To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method. The strategy has already been tested against hepatitis and adeno-associated viruses in cell cultures. It may also prove successful against coronaviruses.

There are antibiotics against dangerous bacteria, but few antidotes to treat acute viral infections. Some infections can be prevented by vaccination but developing new vaccines is a long and laborious process.

Now an interdisciplinary research team from the Technical University of Munich, the Helmholtz Zentrum München, and the Brandeis University (USA) is proposing a novel strategy for the treatment of acute viral infections: The team has developed nanostructures made of DNA, the substance that makes up our genetic material, that can trap viruses and render them harmless.

Researchers image an entire mouse brain for the first time

Now just need to go to rat monkey human.

Researchers at the University of Chicago and the U.S. Department of Energy’s (DOE) Argonne National Laboratory have imaged an entire mouse brain across five orders of magnitude of resolution, a step which researchers say will better connect existing imaging approaches and uncover new details about the structure of the brain.

The advance, which was published on June 9 in NeuroImage, will allow scientists to connect biomarkers at the microscopic and macroscopic level. It leveraged existing advanced X-ray microscopy techniques at the Advanced Photon Source (APS), a DOE Office of Science User Facility at Argonne, to bridge the gap between MRI and electron microscopy imaging, providing a viable pipeline for multiscale whole brain imaging within the same brain.

“Argonne had this extremely powerful X-ray microscope, and it hadn’t been used for brain mapping yet, so we decided to try it out.” — Assistant Professor Bobby Kasthuri

Argonne National Laboratory

Argonne researchers across the laboratory complex are using AI to design better materials and processes, safeguard the nation’s power grid, accelerate medical treatments, automate traditional research, and drive discovery.

Armed with some of the world’s brightest minds and best computing resources, Argonne is at the forefront of AI research, playing an integral role in applying innovative AI methods to solve problems and change lives.

Tapping into the Brain to Help a Paralyzed Man Speak

He has not been able to speak since 2003, when he was paralyzed at age 20 by a severe stroke after a terrible car crash.

Now, in a scientific milestone, researchers have tapped into the speech areas of his brain — allowing him to produce comprehensible words and sentences simply by trying to say them. When the man, known by his nickname, Pancho, tries to speak, electrodes implanted in his brain transmit signals to a computer that displays his intended words on the screen.

His first recognizable sentence, researchers said, was, “My family is outside.”

Customizing Soft Robots in a Universal Way

What are Soft Robots?

What are Soft Robots?Soft robots are largely made of readily malleable matter, such as fluids, gels, and elastomers, which may match specific materials in a process known as compliance matching. The idea of compliance matching states that materials that make contact with one other should have similar mechanical stiffness in order to transfer internal load uniformly and reduce interfacial tensile stress. This principle, nevertheless, does not applicable to rigid robots (E=109Pa) engaging with soft materials (E=102-106Pa), causing serious damage or mechanical immobility. These kinds of interactions with soft materials are common, for example, with natural skin, muscular tissue, and sensitive interior organs, but also with creatures, artificial predictor variables of biological functions, and so on. Because of this huge disparity in mechanical compliance, it’s simple to assume that stiff robots are unsuitable, if not hazardous, for close human engagement.

Fermented vs. high-fiber diet microbiome study delivers surprising results

Investigating the relationship between diet, gut bacteria and systemic inflammation, a team of Stanford University researchers has found just a few weeks of following a diet rich in fermented foods can lead to improvements in microbiome diversity and reductions in inflammatory biomarkers.

The new research pitted a high-fiber diet against a diet with lots of fermented food. Thirty-six healthy adults were recruited and randomly assigned one of the two diets for 10 weeks.

“We wanted to conduct a proof-of-concept study that could test whether microbiota-targeted food could be an avenue for combatting the overwhelming rise in chronic inflammatory diseases,” explains Christopher Gardner, co-senior author on the new study.

Howard Leonhardt — Founder, Leonhardt Ventures — Bioelectrics & Biologics For Regeneration & Healing

Investing in the convergence of bioelectrics & biologics for regeneration & healing — howard J. leonhardt, founder, leonhardt ventures.

Howard Leonhardt is the Founder of Leonhardt Ventures, the world’s first Innovation Accelerator focused on the convergence of bioelectrics & biologics for organ regeneration and tissue healing.

Howard is an accomplished inventor and serial entrepreneur, with 21 U.S. patents, over 100 patent claims for products for treating cardiovascular disease, and has over 40 new patent claims pending. His TALENT (Taheri-Leonhardt) stent graft, developed in the early 1990′s, holds a leading world market share for repairing aortic aneurysms without surgery.

Howard’s inventions to date have been involved in treated over 500000 patients in 60 countries.

Howard is co-leader of Startup California and Founder and Chairman of The California Stock Exchange TM (Cal-X) preparing to be the first social good impact stock exchange currently operating the Cal-X 30 Social Good Impact fund. He founded Cal-X Crowdfund Connect, a crowdfunding campaign management company, and Cal-X Stars Business Accelerator, Inc., a business incubator and accelerator focused on cardiovascular life sciences and social good impact innovations.

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