Super-charging a treatment for leukemia also makes it effective on solid tumors.
Category: biotech/medical – Page 2120
The past decade of Alzheimer’s disease research has been fraught with disappointment.
Years of focus on one hallmark of the disease ultimately resulted in no progress toward treatment or prevention.
But next week, when top scientists gather in Los Angeles at the Alzheimer’s Association International Conference, an annual meeting, many will present research on a different target: inflammation.
A simple cold virus could wipe out tumors in a form of bladder cancer, a small new study suggests.
Though the idea of using viruses to fight cancer isn’t new, this is the first time a cold virus effectively treated an early-stage form of bladder cancer. In one patient, it eliminated a cancerous tumor, the group reported July 4 in the journal Clinical Cancer Research.
A group of researchers conducted an early-stage clinical trial in which they infected 15 bladder cancer patients with coxsackievirus A21, which is one of the viruses that cause the common cold. Coxsackievirus is not a genetically modified virus; it’s “something that occurs in nature,” said senior author Hardev Pandha, a professor of medical oncology at the University of Surrey in England. [Exercise May Reduce the Risk of These 13 Cancers].
Is comprehensive damage repair feasible? A debate at Undoing Aging 2019 between Vadim Gladyshev, Harvard Medical School and Aubrey de Grey, SENS Research Foundation.
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Vadim N. Gladyshev is a professor at Harvard Medical School, Brigham and Women’s Hospital and an expert and pioneer in antioxidant/redox biology. He is known for his characterization of the human selenoproteinencoded by 25 genes. He has conducted studies on whether organisms can acquire cellular damage from their food;the role selenium plays as a micro-nutrient with significant health benefits;In 2013 he won the NIH Pioneer Award.
Aubrey David Nicholas Jasper de Grey is an English author and biomedical gerontologist. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc.
A 22-year-old woman from the Netherlands who suffers from a chronic bone disorder — which has increased the thickness of her skull from 1.5cm to 5cm, causing reduced eyesight and severe headaches — has had the top section of her skull removed and replaced with a 3D printed implant.
The operation was performed by a team of neurosurgeons at the University Medical Centre Utrecht and the university claims this is this first instance of a successful 3D printed cranium that has not been rejected by the patient.
Those who had adhered to statin treatment vs those who had not were found to have 34% lower all-cause mortality rates. Fewer atherosclerotic cardiovascular disease events were reported in relation to adherence to statins. Irrespective of age and sex, reduced mortality and cardiovascular morbidity may be seen in older adults in relation to adherence to statins.
Internal Medicine Article: Statin use over 65 years of age and all-cause mortality: A 10-year follow-up of 19,518 people.
YaleNew
In a stunning scientific breakthrough, Yale School of Medicine researchers restored brain activity in pigs that had died hours before. The finding could revolutionize the neuroscience field and how scientists conceive the boundaries between life and death.
By circulating a cocktail of cell-rejuvenating compounds throughout the pigs’ brains, the researchers prevented tissue decomposition and restored some cell function. If replicated, their technique could be used as a model for drug testing and has implications for how scientists understand brain plasticity after traumatic events such as strokes.
The drugs we’ve developed to help us deal with chronic pain largely focus on suppressing its symptoms, rather than eliminating its underlying causes. By studying the way pain works in injured fruit flies, scientists have for the first time uncovered evidence that its effects can be long-lasting, something they say opens up new opportunities for more effective treatments in humans.
Each cell works differently.
When viruses enter the body, such as during an influenza or a gastrointestinal infection, the processes within the infected cells change: In the worst case, the virus takes the helm and reprograms the cell to its advantage. It then produces viral components on a massive scale allowing the intruder to multiply exponentially.
In other cells, however, the virus may be successfully eliminated by the activation of cellular defense mechanisms. But how can it be that one cell is overrun and another succeeds in getting the virus under control? How quickly do individual cells react to a viral attack and which protective genes are activated?
Scientists at the Julius Maximilian University of Würzburg and the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have investigated these questions. They have developed a new method, scSLAM-seq, which enables them to track the activity of thousands of genes in individual cells over several hours. For the first time, the researchers were able to explain why some cells are successfully infected by a virus, whereas others are not. In addition, they also gained fundamental new insights into the regulation of genes. Their results are published in the July, 18th issue of the scientific journal Nature.
A UK reporter’s harrowing story of losing sight in his right eye is sure to terrify anyone who’s been lax about contact lens hygiene. He contracted a rare parasitic infection, likely as a result of showering with his contacts in. The costly mistake required over 18 months of intensive treatments, and there’s a chance he may never see out of his right eye again.
Nick Humphreys, a 29-year-old senior reporter at the local Shropshire Star, told his tale in a column for the outlet this week. According to Humphreys, the trouble began in January 2018. His right eye, which had been noticeably dry for a week, became incredibly sensitive to light and filled with pain. After over-the-counter eye drops failed to do anything, he visited an eye doctor, where an ulcer was discovered. A visit to the hospital afterward eventually revealed the culprit of his symptoms: an infection of the cornea caused by a protozoan called Acanthamoeba.