Lifeboat Foundation

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Senolytics are the first therapies that directly target the aging process to delay or prevent age-related diseases and are now in human trials. Today we thought it was the ideal time to have a look at how they work and the companies involved.

Senescent cells and aging

Continue reading “The First Therapy that Targets Aging is in Human Trials Now” »

As we get older, more and more of our the cells in our bodies become dysfunctional and enter into a state known as senescence. These senescent cells no longer divide or support the tissues and organs of which they are part; instead, they secrete a range of harmful inflammatory chemical signals, which are known as the senescence-associated secretory phenotype (SASP).

For more aging research news visit: https://www.leafscience.org/

Heads up, hunting enthusiasts: The Michigan Department of Natural Resources (DNR) is warning hunters in the state to be wary of bovine tuberculosis in deer, a disease that’s transmissible to humans, WSMH-News reported.

The “serious contagious disease” is caused by the bacteria Mycobacterium bovis, according to Purdue University. It’s spread “primarily through the exchange of respiratory secretions between infected and uninfected animals,” such as coughing or sneezing, according to the Michigan DNR.

Oklahoma Man Faces Charges For Shooting Deer Hours Before Hunting Season Starts

Continue reading “Michigan wildlife officials warn hunters of ‘serious contagious disease’ in deer” »

Today, we have a talk by Dr. Alvaro Macieira-Coelho, who discusses how aging is a consequence of thermodynamics and entropy. Quite simply, aging is the default for most species.

Earlier this year, we hosted the Ending Age-Related Diseases 2018 conference at the Cooper Union, New York City. The event was focused on bringing the worlds of research and investment in the rejuvenation biotechnology field together and saw a number of talks and panels focused on research and investment.

Continue reading “Aging Happens” »

Invariant natural killer T cells might lead to cheaper and more effective immunotherapy.

Researchers at the Imperial College London have discovered that specifically employing invariant natural killer T cells, rather than generic T cells, in cancer immunotherapies based on chimeric antigen receptors might lead to significantly more effective, cheaper, and more easily mass-produced treatments [1].

Abstract

Continue reading “Invariant Natural Killer T Cells Might Be The Next Step in Cancer Therapy” »

Here at LEAF, we engage in a wide range of activities in support of the development of rejuvenation biotechnology in order to end age-related diseases. We report the latest news in aging research, attend conferences and give talks, educate, advocate, and fundraise for research projects on Lifespan.io; recently, we implemented the Longevity Investor Network in order to bring startup companies and investors together.

The Longevity Investor Network

The Longevity Investor Network is a group of investors who meet every month and invite young biotech companies working on aging to pitch their ideas. A successful pitch can often mean funding for a new startup company, helping to get its product developed and into clinical trials.

Continue reading “Bioquark Inc. — Real Bodies Milano Exhibit — Ira Pastor” »

Scientists found out that nonclassical monocites can become senescent.

Scientists from the A*STAR Singapore Immunology Network have discovered that immune cells called nonclassical monocytes undergo cellular senescence, contradicting what was previously thought of them [1].

Abstract

Continue reading “Type of Human Monocytes Found to Undergo Senescence” »

In the United States – the world’s biggest and most advanced pharmaceutical market – of the 46 new drugs given consent for marketing by regulators last year, 28 were developed by US firms and the realisation of all but four of the rest were led by European firms. None were Chinese.

China’s big ambitions to become a powerhouse of pharmaceutical innovation is as much about the well-being of its people as it is about narrowing the gap with the West.