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A few hundred of the thousands of proteins circulating in our blood turn out to be a fairly accurate forecaster of a person’s age, scientists reported Thursday — though one’s biological age, which doesn’t always match one’s number of years.

This “proteomic clock,” as the researchers call it, relies on measurements of levels of the proteins, which rise and fall over the years. While it’s a nifty discovery, for now it remains just that. Researchers need to first develop a much better understanding of these proteins; if they can, they said, it might be possible to one day look at their levels to gauge the success of drugs being tested in clinical trials, or even to develop a therapy from a cocktail of proteins that could act like a rejuvenation boost or improve health.

“Why are these proteins so tightly linked to aging?” said Tony Wyss-Coray, professor of neurology and neurological sciences at Stanford and the senior author of the paper4, which was published Thursday in the journal Nature Medicine.

More: https://www.burzynskimovie.com/
About the director: https://ericmerola.com
A 2016 updated version of this story: http://estore.burzynskimovie.com/

More info http://www.burzynskimovie.com

Directed by Eric Merola
http://www.ericmerola.com

Learn more about the director: http://merolaproductions.com/eric-merola-bio

Burzynski, the Movie is an internationally award-winning documentary originally released in 2010 (with an Extended Edition released in 2011) that tells the true story of a medical doctor and Ph.D biochemist named Dr. Stanislaw Burzynski who won the largest, and possibly the most convoluted and intriguing legal battle against the Food & Drug Administration in American history.

His victorious battles with the United States government were centered around Dr. Burzynski’s gene-targeted cancer medicines he discovered in the 1970’s called Antineoplastons, which have currently completed Phase II FDA-supervised clinical trials in 2009 and has been given permission by the FDA to begin the final phase of FDA testing–randomized controlled clinical trials.

Insights from their study may provide a novel therapeutic approach for diseases such as Huntington’s and Parkinson’s.

Associate Professor Roger Pocock, from the Monash Biomedicine Discovery Institute (BDI), and colleagues from the University of Cambridge led by Professor David Rubinsztein, found that microRNAs are important in controlling , proteins that have amassed due to a malfunction in the process of ‘folding’ that determines their shape.

Their findings were published in eLife today.

A DEADLY infection similar to mad cow disease is spreading in deer — and could infect humans, experts have warned.

Officials are monitoring cases of chronic wasting disease (CWD), which attacks the brain, spinal cord and other tissue, in North America.

The US Centers for Disease Control and Prevention (CDC) says the disease — sometimes referred to as ‘zombie deer’ — has now spread to at least 26 states.

Circa 2014 o.o


The digital health revolution is still stuck.

Tech giants are jumping into the fray with fitness offerings like Apple Health and Google Fit, but there’s still not much in the way of, well, actual medicine. The Fitbits and Jawbones of the world measure users’ steps and heart rate, but they don’t get into the deep diagnostics of, say, biomarkers, the internal indicators that can serve as an early warning sign of a serious ailment. For now, those who want to screen for a disease or measure a medical condition with clinical accuracy still need to go to the doctor.

Dr. Eugene Chan and his colleagues at the DNA Medical Institute (DMI) aim to change that. Chan’s team has created a portable handheld device that can diagnose hundreds of diseases using a single drop of blood with what Chan claims is gold-standard accuracy. Known as rHEALTH, the technology was developed over the course of seven years with grants from NASA, the National Institutes of Health, and the Bill and Melinda Gates Foundation. On Monday, the team received yet another nod (and more funding) as the winners of this year’s Nokia Sensing XChallenge, one of several competitions run by the moonshot-seeking XPrize Foundation.

O.o.


A physicist at the University of California, Riverside, has performed calculations showing hollow spherical bubbles filled with a gas of positronium atoms are stable in liquid helium.

The calculations take scientists a step closer to realizing a , which may have applications in , spacecraft propulsion, and .

Extremely short-lived and only briefly stable, positronium is a hydrogen-like atom and a mixture of matter and antimatter—specifically, bound states of electrons and their antiparticles called positrons. To create a gamma-ray laser beam, positronium needs to be in a state called a Bose-Einstein condensate—a collection of positronium atoms in the same , allowing for more interactions and gamma radiation. Such a condensate is the key ingredient of a gamma-ray laser.

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a study in Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

“We’ve developed a new process for rapidly screening all of the edits made by CRISPR, and it shows there may be many more unintended changes to DNA around the site of a CRISPR repair than previously thought,” said Eric Kmiec, Ph.D., director of ChristianaCare’s Gene Editing Institute and the principle author of the study.

The study describes a new tool developed at the Gene Editing Institute that in just 48 hours can identify “multiple outcomes of CRISPR-directed gene editing,” a process that typically required up to two months of costly and complicated DNA analysis.

Computer scientists from Duke University and Harvard University have joined with physicians from Massachusetts General Hospital and the University of Wisconsin to develop a machine learning model that can predict which patients are most at risk of having destructive seizures after suffering a stroke or other brain injury.

A point system they’ve developed helps determine which patients should receive expensive continuous electroencephalography (cEEG) monitoring. Implemented nationwide, the authors say their could help hospitals monitor nearly three times as many patients, saving many lives as well as $54 million each year.

A paper detailing the methods behind the interpretable machine learning approach appeared online June 19 in the Journal of Machine Learning Research.

Awesome!


A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine.

The ability to circumvent the exhaustion that the genetically engineered cells often experience after their initial burst of activity could lead to the development of a new generation of CAR-T cells that may be effective even against solid cancers—a goal that has until now eluded researchers.

The studies were conducted in mice harboring human leukemia and . The researchers hope to begin in people with leukemia within the next 18 months and to eventually extend the trials to include solid cancers.