Lifeboat Foundation

In recent years, a brain-computer interface (BCI) developed by the US BrainGate consortium has allowed people to control a robotic arm and to type, using only their thoughts. Now, a group of paralyzed volunteers has utilized the technology to perform various functions on a tablet.

Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand … A team from the Institute of biology Valrose (CNRS/Inserm/Université Côte d’Azur), in collaboration with colleagues from the University of Pennsylvania, has shown how a single protein induces a spiral motion in another molecule. Through a domino effect, this causes cells, organs, and indeed the entire body to twist, triggering lateralized behaviour. This research is published in the journal Science on November 23, 2018.

Researchers have combined a form of graphene with a seaweed-derived substance to create a whole new smart material with multiple uses.

A number of biomedical applications have begun to adopt hydrogel materials made from alginate, a natural material derived from seaweed. Yet in their current form, these hydrogels are incredibly fragile, meaning they’re not very useful in the long term.

However, researchers at Brown University have found a way to drastically improve their strength – in addition to making them more intricate in shape – using graphene oxide (GO) and 3D printing.

Continue reading “When graphene and seaweed combine, something amazing happens” »

Sir Aaron Klug, OM, who has died aged 92, won the 1982 Nobel Prize in Chemistry for his development of crystallographic electron microscopy and his work in charting the infinitely complex structures of chromosomes, the body’s largest molecules.

Human genes are made of nucleic acids such as DNA (deoxyribonucleic acid). The acids are too small to be seen with an ordinary microscope and too large to be studied by examining them under X-rays.

In a study published in the journal Immunology, Southampton University researchers have shown that a new antibody that they have engineered is able to combine two different anticancer approaches: depleting regulatory T cells and activating killer T cells [1].

Abstract

The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote CD8 T cell-dependent anti-tumor immunity in pre-clinical cancer models. We found that T regulatory (Treg) cells infiltrating human or murine tumors expressed high amounts of 4-1BB. Intra-tumoral Treg cells were preferentially depleted by anti-4-1BB mAbs in vivo. Anti-4-1BB mAbs also promoted effector T cell agonism to promote tumor rejection. These distinct mechanisms were competitive and dependent on antibody isotype and FcgR availability. Administration of anti-4-1BB IgG2a, which preferentially depletes Treg cells, followed by either agonistic anti-4-1BB IgG1 or anti-PD-1 mAb augmented anti-tumor responses in multiple solid tumor models.

Continue reading “Dual-Action Antibody Might Improve Immunotherapy Outcomes” »

The latest podcast with Liz Parrish with Elite Man Magazine. Her story, how she intends to tackle disease, and how she views the future. Once we have cured all diseases, we can color our skin green and our eyes purple. Wow!

Check out this incredible interview with BioViva CEO Liz Parrish as she talks about how to stop aging, grow taller, build incredible muscle mass, and reverse disease using gene therapy!

What is Immortality?

https://www.guidebooktolife.com/are-we-close-to-immortality?…rl10y2xoME

https://upjourney.com/exciting-healthcare-startups-to-watch-…6Ah4-sGT_c

Julie K. Andersen at the Buck Institute for Research on Aging in Novato as a speaker for the 2019 Undoing Aging Conference.

“Julie has been associated with SENS since its earliest days: she participated in the first workshop that I organised to discuss it, in 2000, and she was a co-author on the first SENS paper in 2002. We’re delighted to be funding her laboratory at the Buck Institute to explore new ways of eliminating neurofibrillary tangles from neurons of Alzheimer’s sufferers, and at UA2019 we will hear about their initial progress.” says Aubrey de Grey.

https://www.undoing-aging.org/news/dr-julie-k-andersen-to-sp…Qq6fZbArkM #

Continue reading “Happy to announce Prof” »