Lifeboat Foundation

LG’s latest flagship looks cool, but that feeling wears off… quickly.

Diabetics can say goodbye to the finger-prick if we design non-invasive glucometers as described here!

Lying within our muscles are stem cells, invisible engines that drive the tissue’s growth and repair. Understanding the signal(s) that direct muscle stem cells to spring into action could uncover new ways to promote muscle growth. However, these mechanisms are poorly understood.

Now, scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.

“Muscle stem cells can ‘burn out’ trying to regenerate tissue during the natural aging process or due to chronic muscle disease,” says Alessandra Sacco, Ph.D., senior author of the paper and associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “We believe we have found promising drug targets that direct muscle stem cells to ‘make the right decision’ and stimulate muscle repair, potentially helping muscle tissue regeneration and maintaining tissue function in chronic conditions such as muscular dystrophy and aging.”

Continue reading “Boosting muscle stem cells to treat muscular dystrophy and aging muscles” »

Up to 50% of women skip potentially life-saving mammograms often because the procedure can cause extreme discomfort and pain. Now researchers have developed a painless, light-based, non-radioactive, 15-second procedure that could revolutionize breast cancer screening and save lives.

Although early detection of breast cancer can significantly increase survival, the radioactive X-ray that requires painful squeezing of the breast to get a good picture is an event that women do not look forward to. Now Caltech researcher Lihong Wang, Ph.D., Bren Professor of Medical and Electrical Engineering, and his colleagues are using their expertise in imaging tissues with light and sound to address this problem. Their development of a revolutionary breast scanning system known as photoacoustic computed tomography (PACT) is reported in the June issue of Nature Communications.²

“The technique developed by Wang and his colleagues combines light and sound to peer noninvasively into tissues without the radioactivity of an X-ray,” explained Behrouz Shabestari, Ph.D., director of the Program in Optical Imaging at the National Institute of Biomedical Imaging and Bioengineering, which funded the study. “PACT is also superior to MRI, which is expensive and sometimes requires the injection of contrast agents, commonly gadolinium. Gadolinium cannot be used in individuals with kidney disease and has recently been shown to accumulate in the bones and brain with unknown long-term effects.”

Continue reading “Light-based, 15-second scan aims to replace painful mammograms” »

Circa 2012

Blood tests convey vital medical information, but the sight of a needle often causes anxiety and results take time. A new device developed by a team of researchers in Israel, however, can reveal much the same information as traditional blood test in real-time, simply by shining a light through the skin. This optical instrument, no bigger than a breadbox, is able to provide high-resolution images of blood coursing through our veins without the need for harsh and short-lived fluorescent dyes.

On April 25, a SpaceX Falcon 9 rocket will launch cargo to the space station and two organs-on-a-chip experiments designed by University of Pennsylvania scientists. They want to understand why so many astronauts get infections while in space. NASA has reported that 15 of the 29 Apollo astronauts had bacterial or viral infections. Between 1989 and 1999, more than 26 space shuttle astronauts had infections.

Huh and his team have created two separate experiments for this first launch. The first essentially mimics an infection inside a human airway, to see what happens to the bacteria, and the surrounding cells, in orbit. Huh’s BIOLines lab created the actual chips.

A lung chip is made of a polymer, and a permeable membrane is the platform for the human cells. For the lung-on-a-chip, one side of the membrane is coated with lung cells, to process the air, and capillary cells on the other, to provide the blood flow. The membrane is stretched and released to provide the bellows-like effect of real lungs.

Continue reading “Organs on a Chip Experiments Will Investigate the High Rate of Infections in Astronauts” »

St. Jude researchers license technology to Mustang Bio in hopes of bringing treatment to market.

Circa 2016

Just lopped off your ring finger slicing carrots (some time in the future)? No problem. Just speed-read this article while you’re waiting for the dronebulance. …

“Epimorphic regeneration” — growing digits, maybe even limbs, with full 3D structure and functionality — may one day be possible. So say scientists at Tulane University, the University of Washington, and the University of Pittsburgh, writing in a review article just published in Tissue Engineering, Part B, Reviews (open access until March 8).

Continue reading “Could humans ever regenerate limbs?” »

Regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens, according to a report published online today in The New England Journal of Medicine. Results of the Phase 2, open-label study indicate the antibody, known as UB-421, was safe and did not induce the production of antibody-resistant HIV. The study was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, and United Biopharma, Inc.

The study was conducted in Taiwan and led by Chang Yi Wang, Ph.D., Chief Scientific Officer and Chairperson of United BioPharma, Inc. Twenty-nine volunteers with well-controlled HIV discontinued their normal regimens of daily oral ART at the time of their first infusion or one week later, depending on their ART regimen. Fourteen study participants received eight regular weekly infusions of UB-421, while 15 received eight higher-dose infusions every other week. At the end of the 8- or 16-week treatment period, all volunteers restarted their previous ART regimen and were evaluated in follow-up visits up to eight weeks later. Apart from a single participant who discontinued the study because of a mild skin rash, volunteers in both groups maintained HIV suppression (plasma HIV RNA levels under 20 copies/mL) throughout the treatment period in the absence of ART.

Previous experimental infusions of broadly neutralizing antibodies, or bNAbs, have suppressed HIV for about two weeks by targeting proteins on the virus itself, but the rapid mutation rate of HIV induces antibody-resistant strains that render the treatment ineffective. UB-421 theoretically avoids this possibility by blocking a stable human protein that HIV uses to infect T cells. Indeed, resistance to UB-421 was not seen in this study. Because the small study did not include a comparator group receiving a placebo infusion, further studies have been planned in Taiwan and Thailand to evaluate the safety and efficacy of UB-421 as a treatment for HIV. In a related study, NIAID investigators currently are evaluating the safety of regular infusions of two highly potent bNAbs that may prevent the development of resistant HIV strains by targeting two distinct areas of the virus.

Continue reading “Novel antibody may suppress HIV for up to four months” »