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Category: biotech/medical – Page 1895

Due to the groundbreaking work in superlongevity by Dr David Sinclair and Yuancheng Ryan Lu on the Information Theory of Aging and how epigenetic therapy can be used to reverse aging, I suddenly have a compelling interest in epigenetics. Here is a recent research article that I’d recommend on.

Epigenetics can be defined as ‘the structural adaptation of chromosomal regions so as to register, signal, or perpetuate altered activity states.’ Increased transcription of key regulatory, metabolic, and myogenic genes is an early response to exercise and is important in mediating subsequent adaptations in skeletal muscle. DNA hypomethylation and histone hyperacetylation are emerging as important crucial events for increased transcription. The complex interactions between multiple epigenetic modifications and their regulation by metabolic changes and signaling events during exercise, with implications for enhanced understanding of the acute and chronic adaptations to exercise, are questions for further investigation.

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A book is made of wood. But it is not a tree. The dead cells have been repurposed to serve another need.

Now a team of scientists has repurposed living cells—scraped from frog embryos—and assembled them into entirely new life-forms. These millimeter-wide “xenobots” can move toward a target, perhaps pick up a payload (like a medicine that needs to be carried to a specific place inside a patient)—and heal themselves after being cut.

These are novel living machines. They’re neither a traditional robot nor a known species of animal. It’s a new class of artifact: a living, programmable organism.

Credit: sam kriegman, UVM credit: douglas blackiston, tufts university

Continue reading “Xenobots — World’s First Living Robots created using Super Computer and Frog Cells” | >

Evolutionary Medicine — Linking human pathology with our past, present, and future evolutionary trajectories — ideaXme (http://radioideaxme.com/) welcomes Prof. Dr. Frank Rühli, Director of the Institute of Evolutionary Medicine, University of Zurich — #Ideaxme #EvolutionaryMedicine #Evolution #Microevolution #Paleopathology #BiologicalAnthropology #ComparativeAnatomy #Mummies #Mummy #Hypercholesterinemia #Diabetes #DrugAddiction #Health #Wellness #Regeneration #Longevity #Aging #IraPastor #Bioquark #Regenerage

Ira Pastor, ideaXme exponential health ambassador, interviews Professor Dr. Frank Rühli, Director of the Institute of Evolutionary Medicine and on the Medical Faculty of University of Zurich, and Founding Director, Chair, Full Professor of Evolutionary Medicine.

Ira Pastor Comments

Continue reading “The Health Past Of Mummies: Evolutionary Medicine Insights For Human Diseases Now” | >

Well, it’s a good thing, but not what I was hoping for. 3 gene therapies though Church is otherwise testing 45. But this is not the rejuvenation I was getting optimistic about. Still, I’m sure as I am getting older that I will be grateful when a treatment comes my way for something when I am elderly. But frankly this was overhyped from the start and I was part of that equation spreading a “2025” figure for some time.

Gene Therapy.

An ‘anti-aging’ gene therapy trial in dogs begins, and Rejuvenate Bio hopes humans will be next.

The startup, spun out of George Church’s lab, has tested an experimental therapy that treats four age-related diseases in mice.

Continue reading “An ‘anti-aging’ gene therapy trial in dogs begins, and Rejuvenate Bio hopes humans will be next” | >

Drugmaker Johnson & Johnson is “pretty confident” that it can create a vaccine to combat the deadly coronavirus, an exec said Monday.

Paul Stoffels, the company’s chief scientific officer, said it began working on a vaccine two weeks ago — and is hopeful that it can be developed within months, CNBC reported.

“We have dozens of scientists working on this so we’re pretty confident we can get something made that will work and stay active for the longer term,” Stoffels told CNBC’s “Squawk Box.”

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Gilead Sciences said it is sending an experimental antiviral drug to China for emergency treatment of coronavirus patients as well as testing to see if it works against the virus.

Gilead Sciences Inc. said on Friday that it had provided doses of an experimental antiviral drug to doctors for the emergency treatment of a small number of patients infected by the new coronavirus.

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What is Coronavirus According to the World Health Organization[i], Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV).

What is 2019 Novel Coronavirus (2019-nCoV) The 2019 Novel Coronavirus (2019-nCoV) is a new strain of coronavirus that was first identified during an investigation into an outbreak in Wuhan, China. It’s important to note that how easily a virus spreads person-to-person can vary. Some viruses are highly contagious, while other viruses are less so. Investigations are ongoing to better understand the transmissibility, severity, and other features associated with 2019-nCoV, but there are indications that person-to-person spread is occurring[ii].

Know the Coronavirus Symptoms According to the CDC, patients with confirmed 2019-nCoV infections have reported mild to severe respiratory illnesses with symptoms including:

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Researchers at the Institut Pasteur in France have become the second monitoring team in the world to sequence the entire novel coronavirus (2019-nCoV) genome in an effort to better understand its origin and virulent properties.

Nearly 8,000 reported cases and hundreds of deaths have been reported in at least 19 countries since the outbreak began in Wuhan, China, last December, prompting the World Health Organization yesterday to declare a public health emergency after evidence of human-to-human transmission had surfaced. International healthcare experts have since prioritized research surrounding 2019-nCoV in an effort to understand and tame the global outbreak.

“Sequencing the genome of pathogens is crucial for the development of specific diagnostic tests and the identification of potential treatment options,” explained Sylvie van der Werf, director of the National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur, in a statement.

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