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Category: biotech/medical – Page 1,834

Pfizer to seek emergency vaccine OK Friday, doses could ship in 24 hours

Pharmaceutical companies Pfizer and partner BioNTech will seek emergency government approval for their coronavirus vaccine on Friday, Health and Human Services Secretary Alex Azar said, paving the way for millions of doses to be distributed within 24 hours.

“We will ship millions of doses of vaccine within 24 hours of FDA approval. So my message is hope and help are on the way,” Azar said Thursday as he announced the pending emergency use application during a White House coronavirus task force briefing.

Pfizer’s German partner BioNTech had said this week that it would seek the emergency approval for the vaccine, which showed 94.5 percent efficacy in clinical trials.

Can damage repair give us indefinite youth? | Dr Aubrey de Grey

In the third episode of the Healthy Longevity webinar series, we hear from Dr Aubrey de Grey, Chief Science Officer of the SENS Research Foundation as he joins Prof Brian Kennedy for a science-backed and inspirational conversation on regenerative medicine and the implications of a population that lives longer and in good health.

Register for upcoming webinar episodes here: https://bit.ly/3jhe0SB.

#NUSMedicine #webinarseries

Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.

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All of the proceedings of this webinar, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved to the speaker or NUS. No statement or presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript or other use of the material presented at this course without the permission of the speaker or NUS is prohibited to the full extent of common-law copyright in such material.

It Sure Looks Like Humans Have Found a Way to Reverse Aging

A landmark study shows this age-old tech is the key.

The cure for aging has long been the Holy Grail of medicine. Emerging technologies, like the gene editing tool CRISPR, have opened the floodgates to what may be possible for the future of medical science. The key to slowing down aging, however, may lie in a simple and age-old technique.

Dive deeper. ➡ Read best-in-class health, tech, and science features, and get unlimited access to Pop Mech.

Getting it just right: The Goldilocks model of cancer

Senescence in cancer cells

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Sometimes, too much of a good thing can turn out to be bad. This is certainly the case for the excessive cell growth found in cancer. But when cancers try to grow too fast, this excessive speed can cause a type of cellular aging that actually results in arrested growth. Scientists at Duke-NUS Medical School have now discovered that a well-known signaling pathway helps cancers grow by blocking the pro-growth signals from a second major cancer pathway.

Inhibiting Wnt signaling with ETC-159 reactivates the hyperactive RAS-MAPK , causing cells to led undergo senescence. Many cancers are driven by activating mutations in the RAS-MAPK signaling pathway which triggers a cascade of proteins that directs cells to grow, divide and migrate. Mutations in proteins involved in this cascade can turn on genes that make this process go into overdrive, causing cells to grow out of control and aggressively invade other parts of the body. However, too much RAS-MAPK signaling causes cancer cells to prematurely age, and eventually stop growing—a process called cellular senescence.

Publishing in Cancer Research, the Duke-NUS research team found that another important and well-known biochemical pathway, the Wnt (pronounced “wint”) signaling pathway, allows some cancers to grow by dampening RAS-MAPK signaling.

Hybrid 3D-printing bioinks help repair damaged knee cartilage

This may be good news for those who have damaged joints due to sports or old age.

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Human knees are notoriously vulnerable to injury or wearing out with age, often culminating in the need for surgery. Now researchers have created new hybrid bioinks that can be used to 3D print structures to replace damaged cartilage in the knee.

The meniscus is the rubbery cartilage that forms a C-shaped cushion in your knee, preventing the bones of your upper and lower leg from rubbing against each other. This stuff is susceptible to damage from sports injuries, but can also wear out with age – and if it gets particularly bad, sometimes the only thing left to do is surgically remove some of the damaged meniscus.

For the new proof-of-concept study, researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM) demonstrated a new method for 3D bioprinting that creates both the cartilage and the supporting structures. The team used the Integrated Tissue and Organ Printing System (ITOPS), which has been used in past studies to print complex tissues such as bones, muscles and even ears.

Going beyond the anti-laser may enable long-range wireless power transfer

Ever since Nikola Tesla spewed electricity in all directions with his coil back in 1891, scientists have been thinking up ways to send electrical power through the air. The dream is to charge your phone or laptop, or maybe even a healthcare device such as a pacemaker, without the need for wires and plugs. The tricky bit is getting the electricity to find its intended target, and getting that target to absorb the electricity instead of just reflect it back into the air—all preferably without endangering anyone along the way.

These days, you can wirelessly charge a smartphone by putting it within an inch of a charging station. But usable long-range wireless power transfer, from one side of a room to another or even across a building, is still a work in progress. Most of the methods currently in development involve focusing narrow beams of energy and aiming them at their intended target. These methods have had some success, but are so far not very efficient. And having focused electromagnetic beams flying around through the air is unsettling.

Now, a team of researchers at the University of Maryland (UMD), in collaboration with a colleague at Wesleyan University in Connecticut, have developed an improved technique for wireless power transfer technology that may promise long-range power transmission without narrowly focused and directed energy beams. Their results, which widen the applicability of previous techniques, were published Nov. 17, 2020 in the journal Nature Communications.

Near-infrared probe decodes telomere dynamics

A new synthetic probe offers a safe and straightforward approach for visualizing chromosome tips in living cells. The probe was designed by scientists at the Institute for Integrated Cell-Material Science (iCeMS) and colleagues at Kyoto University, and could advance research into aging and a wide range of diseases, including cancers. The details were published in the Journal of the American Chemical Society.

“Chromosome ends are constantly at risk of degradation and fusion, so they are protected by structures called telomeres, which are made of long repeating DNA sequences and bound proteins,” says iCeMS chemical biologist Hiroshi Sugiyama, who led the study. “If telomeres malfunction, they are unable to maintain chromosome stability, which can lead to diseases such as cancer. Also, telomeres normally shorten with each cell division until they reach their limit, causing cell death.”

Visualizing telomeres, especially their physical arrangements in , is important for understanding their relevance to disease and aging. Several visualization approaches already exist, but they have disadvantages. For example, some can only observe telomeres in preserved, or fixed, cells. Others are time-consuming or involve harsh treatments that denature DNA.

Scientists sequence genome of bowhead whale—longest-lived mammal

Scientists at the University of Liverpool have sequenced the genome of the bowhead whale, estimated to live for more than 200 years with low incidence of disease.

Published in the journal Cell Reports, the research could offer new insight into how animals and humans could achieve a long and healthy life.

Scientists compared the genome with those from other shorter-lived mammals to discover unique to the bowhead whale.