Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1677

Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.

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Data governs our lives more than ever. But when it comes to disease and death, every data point is a person, someone who became sick and needed treatment.

Recent studies have revealed that people suffering from the same disease category may have different manifestations. As doctors and scientists better understand the reasons underlying this variability, they can develop novel preventive, diagnostic and therapeutic approaches and provide optimal, personalized care for every patient.

To accomplish this goal often requires broadscale collaborations between physicians, basic researchers, theoreticians, experimentalists, computational biologists, computer scientists and data scientists, engineers, statisticians, epidemiologists and others. They must work together to integrate scientific and medical knowledge, theory, analysis of medical big data and extensive experimental work.

This year, the Israel Precision Medicine Partnership (IPMP) selected 16 research projects to receive NIS 60 million in grants with the goal of advancing the implementation of personalized healthcare approaches – providing the right treatment to the right patient at the right time. All the research projects pull data from Israel’s unique and vast medical databases.

Continue reading “Israeli researchers explain how they are healing the world with precision” | >

“Now, nearly 2,000 people in and around Leticia are sick with COVID-19. About 70 have died. That might not sound like a colossal death toll at first. But because the surrounding state of Amazonas is sparsely populated, this amounts to the highest per-capita death rate in all of Colombia, according to figures from Colombia’s Health Ministry.”

The governor of Amazonas, Colombia, says it was impossible to cut the area off from Brazil, even as the virus spiked. Now the Colombian border town of Leticia is a coronavirus hot spot.

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Scientists in Europe have created embryo-like structures that mimic a crucial yet enigmatic stage of human development.

The structures, created from stem cells and called gastruloids, are the first to form a 3D assembly that lays out how the body will take shape. The gastruloids developed rudimentary components of a heart and nervous system, but lacked the components to form a brain and other cell types that would make them capable of becoming a viable fetus.

Researchers are creating ever more sophisticated artificial structures to study embryo development in the lab. The latest method for making these structures, published in Nature today1, could shed light on the causes of pregnancy loss and early developmental disorders, such as congenital heart conditions and spina bifida.

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BioMed Realty, a real estate development firm that specializes in life-sciences and biotech space, is taking over development of a multi-acre site in Somerville’s Assembly Square to create a “best-in-class life science office park.”

BioMed has agreed to acquire an existing office at 5 Middlesex Ave. in Somerville, as well as 7.5 acres of land for future development, from a joint venture of Novaya Real Estate Ventures and Cresset Development. The firms did not disclose terms of the agreement.

BioMed, which investment giant Blackstone acquired in 2016, has a local portfolio spanning 3.5 million square feet, including a number of properties in Cambridge, as well as facilities in Watertown and Boston’s Longwood Medical Area. Its most recent project proposal in Cambridge is for a 16-story office and lab at 585 Third St.

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True genetic isolation is hard to pull off. Human populations tend to mix when they are in close proximity.

Consider the Hui people. These are Muslims who live across China and speak the local Chinese dialect of their locale. The Hui claim descent from Central Asians and Persians who arrived in China around 1,000 years ago. But the vast majority of their genomes are no different from the Han Chinese. Physically they are impossible to distinguish from Han Chinese unless you take note of their attire.

How can that be when they are so culturally different? For example, as Muslims the Hui do not eat pork and consider it unclean. In contrast, for the majority Han pork is dietary staple.

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Many cultures have found religious experiences with creatures and this soronan desert road has naturally occurring dmt with has actually created many religious organizations for centuries.

Our Vice Mexico team went to the Sonora desert in search of the Bufo Alvarius, an endemic toad species that contains a very high dosage of 5-MEO-DMT in it´s body. 5-MEO-DMT is said to be the most potent hallucinogenic in the world.

Our guide through this trip was Octavio Rettig, a doctor who has studied this toad for more than eight year and has brought the medicine — as he calls the substance — all over the world.

Continue reading “Getting High with a Hallucinogenic Toad Prophet” | >