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Category: biotech/medical – Page 161

Metabolic inflammation at the adipose-brain axis

Adipose-brain axis in metabolic inflammation.

White adipose tissue (WAT) in addition to storing excess energy also releases cytokines, lipid mediators, adipokines, and extracellular vesicles that influence brain physiology.

The inflammatory mediators disrupt key brain interfaces, including the blood-brain barrier (BBB), perivascular and glymphatic clearance pathways, promoting endothelial dysfunction, altered astrocyte-pericyte support, impaired amyloid-b clearance, and region-specific glial activation.

In the brain, obesity-associated neuroinflammation leads to various neuronal dysfunction including cognition.

The authors discuss the role of adipokines in adipose-brain communication during obesity including how they contribute to neuroinflammation and synaptic dysfunction.

The authors also discuss therapeutic strategies targeting the adipose-brain axis, including exercise and dietary interventions and pharmacological approaches such as orlistat and incretin-based therapies. sciencenewshighlights ScienceMission https://sciencemission.com/adipose-brain-axis

Continue reading “Metabolic inflammation at the adipose-brain axis” | >

Mysterious black goo discovered aboard ship reveals species unknown to science

“The biggest surprise was that the ship goo had life in it at all,” researcher Cody Sheik, who discovered the substance, said in a press release. “We thought we’d find nothing. But surprisingly, we found DNA, and it wasn’t too destroyed, nor was the biomass too low.”

After further analysis, the team reconstructed 20 genomes from the sample. Some appear to represent entirely new branches of life, including what could be a previously unknown order of archaea and even a new bacterial phylum.

Inside the goo, scientists found microbes that thrive in semi-warm environments with no oxygen — conditions that closely match those inside the ship’s mechanical systems. Researchers believe the organisms may have hitchhiked on oil used to grease the rudder, remaining dormant until conditions allowed them to grow.

Scientists Develop New Antibody For Virus That Infects 95% of People

The Epstein-Barr virus (EBV) is one of the world’s most common viruses, thought to be lurking in 95 percent of adults. For most, it causes no obvious symptoms.

But EBV is more than a short-term infection.

Once it enters the body, EBV can stay for life, and it has been linked to several cancers, multiple sclerosis, and other severe health complications. Now, new research has given us a promising way to fight it.

Stealth switch in tuberculosis enzyme could open route to drug-resistant treatment

Recent research published in Communications Biology marks an advance in structural biology by enhancing understanding of protein regulation mechanisms in Mycobacterium tuberculosis (Mtb), a global health threat. The team led by the University of Melbourne combined several advanced techniques at the Australian Synchrotron and the National Deuteration Facility to reveal the hidden allosteric mechanism that activates a key enzyme, ICL2.

The study opens a target pathway to treat drug-resistant TB with modulators that can interfere with the enzyme’s “on switch.” Traditional drugs often targeted the enzyme’s active site, which is difficult to block effectively.

However, ICL2 is unique to mycobacteria and is essential for the survival of the TB bacterium during infection, especially when it is starved of sugar and forced to live on fats.

CDK1-dependent N-terminal NuMA phosphorylation promotes dynein-dynactin-NuMA assembly for accurate chromosome segregation

Van Toorn et al. show that CDK1-mediated phosphorylation of NuMA at serine 203 promotes stable dynein-dynactin-NuMA assembly in human cells. This mitotic phosphorylation thereby contributes to robust spindle formation and accurate chromosome segregation.

Genomic and Transcriptomic Approaches Advance the Diagnosis and Prognosis of Neurodegenerative Diseases

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), represent a growing societal challenge due to their irreversible progression and significant impact on patients, caregivers, and healthcare systems. Despite advances in clinical and imaging-based diagnostics, these diseases are often detected at advanced stages, limiting the effectiveness of therapeutic interventions. Recent breakthroughs in genomic and transcriptomic technologies, including whole-genome sequencing, single-cell RNA sequencing (scRNA-seq), and CRISPR-based screens, have revolutionized the field, offering new avenues for early diagnosis and personalized prognosis.

Genome pioneer Craig Venter dies: here’s how he transformed science

It’s very sad that Craig Venter passed away. One of a few people I’ve admired since middle school. Truly a life well lived.

Venter redrew the boundaries of biology — sequencing DNA at unprecedented speed, engineering synthetic life and charting ocean microbes.

Swine reporter model for preclinical evaluation and characterization of gene delivery vectors

Pigs which express tdTomato upon Cre or CRISPR editing of a genetic cassette inserted into their genome. (Pig analogue of Ai9 mice). This model system will aid translational preclinical studies for gene editing therapies.

A “turn-on” swine reporter model is developed to characterize local and systemic delivery of gene editors in vivo using viral or non-viral vectors. This adds the functionality of a reporter to preclinical gene delivery research in a large animal model that is more broadly accessible than nonhuman primates.

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