Rejuveron increases to near-majority stake in Endogena to progress treatments for degenerative diseases of the eye.
Category: biotech/medical – Page 1,569
Harnessing the power of mitochondria to beat Parkinson’s
Boston-based biotech Vincere Biosciences is on a mission to combat neurodegenerative disease by improving the quality of the mitochondria in our cells. The company was spun out from AI drug discovery company NeuroInitiative in 2018 after its platform identified that modulation of certain enzymes to repair mitochondrial health “may slow or stop the progression of Parkinson’s disease and other age-related disorders.”
In addition to seed funding, Vincere has received grants from the National Institutes of Health and Michael J Fox Foundation, and the company is now gearing up for a Series A funding round in early 2022.
Longevity. Technology: Mitochondria’s role in longevity is a hot topic. Often referred to as the “powerhouse of the cell”, these miniature organs within our cells play a key role in providing the energy needed for growth, repair and rejuvenation. As we age, our mitochondria begin to decline in function, and this decline is linked to a range of age-related diseases. We caught up with Vincere’s co-founder and CEO Dr Spring Behrouz to find out how her company aims to tap into the potential of these small but mighty biological players.
Split-Brains, Consciousness and Combining Minds | Waking Cosmos Documentary
One of the reasons branching identity is being accepted more seriously these days.
Beginning in the 1950s, experiments with split-brain patients revealed that consciousness could be divided between the two hemispheres of the brain. A surprising implication was that if consciousness could be divided, then it could also be combined. Evidence of this came in 2006, when conjoined twins Krista and Tatiana Hogan were born. The Hogan sisters were born with their brains connected by a thalamic bridge, which allowed a unique mental connection between them. We explore this surprising mental connection, and the possibility that we may one day connect our own minds with other conscious beings, together with what this might mean for our concept of self, identity, and the future of mind.
Please consider supporting my work on Patreon here ~ https://www.patreon.com/wakingcosmos.
Thank you!
This documentary is a non-profit, educational film. All footage used with permission, or in compliance with fair use/fair dealing.
Music by Scott Buckley and Aleks Michalski.
Can Mushrooms replace EVERYTHING? | Concrete, Plastic, Meat, Leather
One promising solution to plastic pollution is mycelium or mushroom packaging. It is made of 2 ingredients: mushrooms and hemp. Mycelium is the underground network of very durable, thread-like filaments called hyphae. It is mixed with agricultural waste like wood chips, oat hulls, cotton burrs or hemp hurds.
Link to my Patreon page: https://www.patreon.com/Belinda_Carr.
Chapters.
0:00 Introduction.
1:00 How its made.
2:43 Products.
4:32 Advantages.
5:30 Disadvantages.
6:19 Myths.
7:12 Conclusion.
One of the largest mushroom packaging manufacturers in the world is Ecovative Design, a New York based biotech company founded in 2006. They sent me these samples of their product. Their manufacturing process is pretty straight forward.
Their designers create a 3D CAD model of custom packaging.
A CNC machine routes the design into MDF.
Plastic trays are thermoformed around the MDF pieces.
The tray is filled with their proprietary hemp hurd and mycelium blend.
It is allowed to grow for 4 days in a controlled environment with regulated temperatures, airflow, CO2 and humidity levels.
It is popped out of tray and allowed to continue growing for 2 more days to create a velvety layer of overgrowth.
The packaging is then heat treated to dry out, kill spores and stop the growth process.
This material can last for 30 years in dry, temperature controlled indoor environments. It is also 100% biodegradable and a nutrient for soils and plants. When broken down into 1 cubic centimeter pieces, it will compost in just 45 days. In the ocean, it will compost in 180 days.
Roche, Genentech, Recursion Launch Up-to-$12B AI Drug Discovery Effort
Roche and its Genentech subsidiary have committed up to $12 billion to Recursion in return for using its Recursion Operating System (OS) to advance therapies in 40 programs that include “key areas” of neuroscience and an undisclosed oncology indication.
Recursion OS applies machine learning and high-content screening methods in what the companies said would be a “transformational” model for tech-enabled target and drug discovery.
The integrated, multi-faceted OS is designed to generate, analyze and glean insights from large-scale proprietary biological and chemical datasets—in this case, extensive single-cell perturbation screening data from Roche and Genentech—by integrating wet-lab and dry-lab biology at scale to phenomically capture chemical and genetic alterations in neuroscience-related cell types and select cancer cell lines.
Uncovered: Key to how exercise protects against consequences of ageing
Monash University, Australia scientists have discovered an enzyme that is key to why exercise improves our health. Importantly this discovery has opened up the possibility of drugs to promote this enzyme’s activity, protecting against the consequences of aging on metabolic health, including type 2 diabetes.
The proportion of people worldwide over 60 years old will double in the next three decades and by 2031, more than six million Australians will be over 65 years old. The incidence of type 2 diabetes increases with age so this aging population will also result in an increased incidence of the disease globally.
One of the main reasons for the increased prevalence of type 2 diabetes with age is the development of insulin resistance, or an inability for the body to respond to insulin, and this is often caused by reduced physical activity as we age.
Mayo Clinic research finds immune system responds to mRNA treatment for cancer
ROCHESTER, Minn. ― Adding messenger RNA, or mRNA therapy improves the response to cancer immunotherapy in patients who weren’t responding to the treatment, Mayo Clinic research shows. Immunotherapy uses the body’s immune system to prevent, control and eliminate cancer. The study is published in Cancer Immunology Research, a journal of the American Association for Cancer Research.
The phrase messenger RNA and its acronym, mRNA, have become familiar to the public during the COVID-19 pandemic. The mRNA vaccines for COVID-19 work by instructing cells in the body how to make a protein that triggers an immune response against the virus.
MRNA technology has also been of interest to cancer researchers and physicians. One of the major obstacles in cancer treatment is the low response rate in patients who receive immune checkpoint inhibitors to prevent an immune response from being so strong that it destroys healthy cells in the body.
N Of 1 Extend Lifespan Experiment: How To Start | Dr Michael Lustgarten Interview Series 3 Ep 1
In this video Dr. Lustgarten introduces his N of 1 experiment and gives an overview of the processes that he follows. He also discusses why he thinks it is important to track your own markers and not just rely on published trials.
Dr. Michael Lustgarten is a scientist at the Tufts University Human Nutrition Research Center on Aging in Boston, Massachusetts. His research currently focuses on the role of the gut microbiome and serum metabolome on muscle mass and function in older adults.
In this series of interviews Dr Lustgarten shares his experience with his rigorous n of 1 experiment over the last 7 years and shows how we or anyone can conduct a similar trial by tracking food, exercise and sleep, measure results and derive relationships between them, with a goal of extending our healthspan.
Dr Lustgarten’s channel on YouTube: https://www.youtube.com/channel/UCT1UMLpZ_CrQ_8I431K0b-g.
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