Lifeboat Foundation

“Magufuli, who holds a doctorate in chemistry, said the testers had randomly obtained several non-human samples on animals and fruits which included a sheep, a goat and a pawpaw and the results came out positive. The samples were given human names and ages and were submitted to the country’s National Referral Laboratory to test for coronavirus without the lab technicians knowing the true identity of the samples.”

Tanzania president John Magufuli is under mounting pressure from concerns around coronavirus.

Broad-spectrum antivirals are desirable, particularly in the context of emerging zoonotic infections for which specific interventions do not yet exist. Sheahan et al. tested the potential of a ribonucleoside analog previously shown to be active against other RNA viruses such as influenza and Ebola virus to combat coronaviruses. This drug was effective in cell lines and primary human airway epithelial cultures against multiple coronaviruses including SARS-CoV-2. Mouse models of SARS and MERS demonstrated that early treatment reduced viral replication and damage to the lungs. Mechanistically, this drug is incorporated into the viral RNA, inducing mutations and eventually leading to error catastrophe in the virus. In this manner, inducing catastrophe could help avoid catastrophe by stemming the next pandemic.

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Here, we show that the ribonucleoside analog β-d-N⁴-hydroxycytidine (NHC; EIDD-1931) has broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c bat-CoVs, as well as increased potency against a CoV bearing resistance mutations to the nucleoside analog inhibitor remdesivir. In mice infected with SARS-CoV or MERS-CoV, both prophylactic and therapeutic administration of EIDD-2801, an orally bioavailable NHC prodrug (β-d-N⁴-hydroxycytidine-5′-isopropyl ester), improved pulmonary function and reduced virus titer and body weight loss. Decreased MERS-CoV yields in vitro and in vivo were associated with increased transition mutation frequency in viral, but not host cell RNA, supporting a mechanism of lethal mutagenesis in CoV.

Coronavirus disease 2019 (COVID-19) presents with a broad clinical spectrum, varying from asymptomatic infection to severe pneumonitis, leading to acute respiratory distress syndrome (ARDS) and death(Guan, et al 2020). Accumulating evidence suggests that in severe COVID-19, an acute hyperinflammatory syndrome characterised by fever, hypoxia and increased serum inflammatory markers, occurring 5–10 days from the first symptoms, is the major driver of morbidity and death(Zhou, et al 2020b). Hyperinflammation is not specific to COVID-19. Similar syndromes were previously described in respiratory disease associated with other coronaviruses, including the severe acute respiratory syndrome-coronavirus (SARS-CoV) in 2003 and Middle East respiratory syndrome-coronavirus (MERS-CoV) in 2012(Castilletti, et al 2005, Tseng, et al 2005).

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I shared about this startup in January, now it’s hitting US Markets. The Israeli startup Sonovia, which sped up efforts to manufacture masks using its anti-pathogen fabric at the start of the coronavirus crisis in Israel, has launched commercial sales.

“When coronavirus started, we were an Israeli startup,” Dr. Jason Migdal, a research scientist with Sonovia, told The Jerusalem Post. “Now, we are a commercial business that is having success internationally.”

Sonovia developed an almost-permanent, ultrasonic, fabric-finishing technology for mechanical impregnation of zinc oxide nanoparticles into textiles.

Continue reading “Israeli masks designed with unique anti-pathogen fabric enter US market” »

As if this contagion movie we are living can not get any more strange. A University of Pittsburgh researcher who claimed to have been on the verge of a significant breakthrough in his research on the coronavirus was killed in what appears to me a murder-suicide…

While police are treating the death as a homicide, they have yet to find any evidence that it was related to his research.

Others believe it is the same Kim saying he only looks different because he has had plastic surgery.

And, to add to the mystery, the claims come as the North Korean leader missed yet another high-profile event.

He was noticeably absent as Russia awarded him a medal to mark the 75th anniversary of the victory over Nazi Germany.

Recent sleep surveys show that Singaporeans are among the world’s most sleep-deprived people. Scientists from Duke-NUS Medical School (Duke-NUS) and the University of Tokyo provide new evidence, which supports the presence of a key mechanism that regulates our biological clock. In the study published in PNAS, the team used preclinical models to validate that mutations in PER2 protein can alter the balance of the circadian period, which can lead to sleep disorders.

Biological clocks are an organism’s innate timing device. It is composed of specific proteins called clock proteins, which interact in cells throughout the body. Biological clocks produce and regulate circadian rhythms —the physical, mental, and behavioral changes that follow a daily cycle. Understanding the molecular mechanisms of the circadian clock provides a huge potential to identify therapeutic interventions to mitigate circadian disruption, and its long-term consequences such as diabetes, obesity and cancer among shift workers, who undergo frequent circadian disruption and are more prone to these diseases.

The Duke-NUS scientists had previously discovered that mutations in a specific protein (called casein kinase 1) alters the core clock protein (called PERIOD or PER), and this changes the timing of the biological clock. In this study, preclinical models were used to investigate the role of PER2 (a type of PER protein) in clock regulation to further understand and strengthen the model.

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

The find has implications for drug design, genetics and biomedical research and is described in a study published on April 21, 2020, in the Proceedings of the National Academy of Sciences. To illustrate the biological ramifications, study co-authors Oleg Igoshin, Anatoly Kolomeisky and Joel Mallory of Rice’s Center for Theoretical Biological Physics (CTBP) used three wide-ranging examples: protein folding, enzyme catalysis and motor protein efficiency.

Igoshin said the symmetry “wasn’t that hard to prove, but no one noticed it before.”

Why hasn’t #MachineLearning conquered SARS-CoV-2 that causes COVID-19 (P.S., SARS-CoV-2 is the name of the #virus, while COVID-19 is the name of the disease)? One of the possible answers is that the virus “learns” faster than machines through “mutations”.

That causes us thinking: If mutation is such an efficient weapon (for virus), can we learn something from it and then apply our understanding to #DeepLearning to create “fast-mutating” #DeepLearning models capable of helping us to fight intractable crisis like a #pandemic?

https://bit.ly/3c9GE5s

Continue reading “Mechanisms of viral mutation” »