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Retinal Cell Map Could Advance Precise Therapies for Blinding Diseases

Researchers have identified distinct differences among the cells comprising a tissue in the retina that is vital to human visual perception. The scientists from the National Eye Institute (NEI) discovered five subpopulations of retinal pigment epithelium (RPE)—a layer of tissue that nourishes and supports the retina’s light-sensing photoreceptors. Using artificial intelligence, the researchers analyzed images of RPE at single-cell resolution to create a reference map that locates each subpopulation within the eye. A report on the research published in Proceedings of the National Academy of Sciences.

“These results provide a first-of-its-kind framework for understanding different RPE cell subpopulations and their vulnerability to retinal diseases, and for developing targeted therapies to treat them,” said Michael F. Chiang, M.D., director of the NEI, part of the National Institutes of Health.

“The findings will help us develop more precise cell and gene therapies for specific degenerative eye diseases,” said the study’s lead investigator, Kapil Bharti, Ph.D., who directs the NEI Ocular and Stem Cell Translational Research Section.

Does Earth Have a Mind and Agency of Its Own?

Does our planet have a mind and agency of its own? This is one of the main questions philosopher and mystic Oberon Zell illuminates in his latest masterpiece GaeaGenesis: Conception and Birth of the Living Earth. Just as we don’t see a bacterium with a naked eye, we don’t quite seem to have an innate ability to perceive the Gaian mind with a “naked” brain. As Dr. Ralph Metzner, Professor Emeritus of California Institute of Integral Studies and Founder-President of The Green Earth Foundation, writes: “Oberon Zell was the first person to conceive and publish the biological and metaphysical foundations of what has become known as the ‘Gaia Theory’ — the unified body and emergent soul of the living Earth… For over 50 years Oberon has been writing and lecturing on Gaian consciousness, and it is high time that he put it all together into a book!” And, indeed, he did.

The newly-released book takes the idea beyond the metaphorical realm postulated by James Lovelock in his “Gaia Hypothesis” and posits that the entire evolution of life on Earth is the literal embryology of a single vast living being — one replicating continuum of DNA and protoplasm. This distinction has significant implications for the subject of this book: The proposition that Mother Earth is a living, sentient being with a “soul” that humans can perceive if they are aware enough to sense it. In essence, the living beings that populate the Earth are cells within a greater macro-organism.

Here’s one of the revelatory passages from the book: To better understand the planet as a living system, we need to go beyond the time scales of human life to the planet’s own time scale, vastly greater than our own. Looked at in this way, the rhythm of day and night might be the pulse of the planet, one full cycle of every hundred thousand human heartbeats. Speeding up time appropriately, we would see the atmosphere and ocean currents swirling round the planet, circulating nutrients and carrying away waste products, much as the blood circulates nutrients and carries away waste in our own bodies.

Ancient Cave Art in Alabama May Be The Largest Ever Found in North America

New details of our past are coming to light, hiding in the nooks and crannies of the world, as we refine our techniques to go looking for them. Most lauded is the reconstruction of the evolution of humanity since our African origins around 300,000 years ago, by analyzing our living and fossil DNA.

Replete with the ghosts of African and Eurasian populations of the deep past, these have been resurrected only through the ability of science to reach into the world of the minuscule by studying biomolecules.

Now, digital analysis of rock surfaces reveals how other ghosts of the deep past – this time from almost 2,000 years ago in North America – have been coaxed into the light.

Sirtuin 6 : Summary Of Key Points of Professor Cohen Interview | Modern Healthspan

There is a SIRT6 activator on the market but it is very expensive at a few hundred dollars.


We have had requests for a summary of the interview with Prof Cohen. This video is a summary of the key points from the interviews. As I note in the introduction, this is my interpretation of what Prof Cohen said, please check the original interviews if you have any questions. And please do feel free to let me know if you think I got something wrong!

Professor Haim Cohen is the director of the Sagol Healthy Human Longevity Center at Bar-Ilan University where he focuses much of his research on the SIRT6 protein. In May 2021 he and his team published a paper showing a 30% increase in lifespan in a mouse model by over expressing SIRT6.

Prof Cohen’s page at the university.
https://life-sciences.biu.ac.il/en/node/641
Prof Cohen’s Lab.
https://www.haimcohenlab.com/

Prof Cohen’s Paper on Sirt6 is here.

Longevity Research is an Economic Necessity

It is vital to recognize the immediate economic importance of i nvesting in longevity and healthy-aging sciences.

Aging itself is a complex series of at least 300 biological processes involving more than 10% of our genetic makeup. It follows that methods to combat these effects must be a combination of sciences, from biotech to biophysics and pharmaceuticals. There is no single “silver bullet” solution.

Aging, along with the physical and mental decay that accompanies it, is still widely regarded as a natural and inevitable thing. It is not, it is a degenerative disease in which the physical integrity and structure of our cells decay each time they divide to replace old ones or as part of any healing process.

‘Nanomagnetic’ computing can provide low-energy AI, researchers show

Researchers have shown it is possible to perform artificial intelligence using tiny nanomagnets that interact like neurons in the brain.

The new method, developed by a team led by Imperial College London researchers, could slash the of (AI), which is currently doubling globally every 3.5 months.

In a paper published today in Nature Nanotechnology, the international team have produced the first proof that networks of nanomagnets can be used to perform AI-like processing. The researchers showed nanomagnets can be used for ‘time-series prediction’ tasks, such as predicting and regulating insulin levels in .

Scientists engineer a bacteria to produce a drug used to treat Parkinson’s disease

The results of the study could lead to new treatment options. In a groundbreaking new study published in the journal Nature on Thursday, researchers have compared the brain cells of patients who had died from either Parkinson’s disease or dementia to people unaffected by the disorders and found which brain cells are responsible for both conditions.


A team of researchers has created a bacteria that can produce a steady and consistent source of medicine inside a patient’s gut, suggesting the possibility for genetically edited bacteria to be an efficient Parkinson’s disease treatment.

Moreover, the researchers have shown via preclinical experiments that the novel treatment technique is not only safe and well-tolerated, but it also reduces side effects that can occur when other treatments are utilized.

An engineered probiotic

For long, scientists have been experimenting with ways of engineering bacteria to fit our needs for decades. The new research is the latest example of that.

Blood Test Analysis: Italian Centenarians

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Biomarker timestamps:
Glucose 1:37
HDL 2:43
Triglycerides 4:10
RBCs, Hemoglobin 5:29
Platelets 7:16
Uric Acid 8:37
AST, ALT 11:04
Total Cholesterol 13:55
WBCs 15:47
Total Protein, Albumin, Globulin 17:38
Creatinine 21:27
BUN 22:35

Papers referenced in the video:
Laboratory parameters in centenarians of Italian ancestry.
https://pubmed.ncbi.nlm.nih.gov/17681733/

Risk Factors For Hyperuricemia In Chinese Centenarians And Near-Centenarians.
https://pubmed.ncbi.nlm.nih.gov/31908434/

Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.
https://pubmed.ncbi.nlm.nih.gov/32623847/

High-density lipoprotein cholesterol and all-cause mortality by sex and age: a prospective cohort study among 15.8 million adults.