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Category: biotech/medical – Page 1,377

Scientists hid encryption key for Wizard of Oz text in plastic molecules

It’s “a revolutionary scientific advance in molecular data storage and cryptography.”

Scientists from the University of Texas at Austin sent a letter to colleagues in Massachusetts with a secret message: an encryption key to unlock a text file of L. Frank Baum’s classic novel The Wonderful Wizard of Oz. The twist: The encryption key was hidden in a special ink laced with polymers, They described their work in a recent paper published in the journal ACS Central Science.

When it comes to alternative means for data storage and retrieval, the goal is to store data in the smallest amount of space in a durable and readable format. Among polymers, DNA has long been the front runner in that regard. As we’ve reported previously, DNA has four chemical building blocks—adenine (A), thymine (T), guanine (G), and cytosine ©—which constitute a type of code. Information can be stored in DNA by converting the data from binary code to a base-4 code and assigning it one of the four letters. A single gram of DNA can represent nearly 1 billion terabytes (1 zettabyte) of data. And the stored data can be preserved for long periods—decades, or even centuries.

There have been some inventive twists on the basic method for DNA storage in recent years. For instance, in 2019, scientists successfully fabricated a 3D-printed version of the Stanford bunny—a common test model in 3D computer graphics—that stored the printing instructions to reproduce the bunny. The bunny holds about 100 kilobytes of data, thanks to the addition of DNA-containing nanobeads to the plastic used to 3D print it. And scientists at the University of Washington recently recorded K-Pop lyrics directly onto living cells using a “DNA typewriter.”

How image features influence reaction times

It’s an everyday scenario: you’re driving down the highway when out of the corner of your eye you spot a car merging into your lane without signaling. How fast can your eyes react to that visual stimulus? Would it make a difference if the offending car were blue instead of green? And if the color green shortened that split-second period between the initial appearance of the stimulus and when the eye began moving towards it (known to scientists as the saccade), could drivers benefit from an augmented reality overlay that made every merging vehicle green?

Qi Sun, a joint professor in Tandon’s Department of Computer Science and Engineering and the Center for Urban Science and Progress (CUSP), is collaborating with neuroscientists to find out.

He and his Ph.D. student Budmonde Duinkharjav—along with colleagues from Princeton, the University of North Carolina, and NVIDIA Research—recently authored the paper “Image Features Influence Reaction Time: A Learned Probabilistic Perceptual Model for Saccade Latency,” presenting a model that can be used to predict temporal gaze behavior, particularly saccadic latency, as a function of the statistics of a displayed image. Inspired by neuroscience, the model could ultimately have great implications for , telemedicine, e-sports, and in any other arena in which AR and VR are leveraged.

Progress towards a pan-coronavirus vaccine

A universal coronavirus vaccine “could solve the problem of endless new waves of disease caused by variants with reduced vaccine sensitivity”.

Researchers at the Francis Crick Institute in London have shown that a specific area of the SARS-CoV-2 spike protein is a promising target for a pan-coronavirus vaccine that could offer protection against new variants, as well as common colds, and help prepare for future pandemics.

Developing a vaccine against multiple coronaviruses is a challenge because this family of viruses have many key differences, frequently mutate, and generally induce incomplete protection against reinfection. This is why people can suffer repeatedly from common colds, and why it is possible to be infected multiple times with different variants of SARS-CoV-2.

A pan-coronavirus vaccine would need to trigger antibodies that recognise and neutralise a range of coronaviruses – stopping the virus from entering host cells and replicating.

Researchers develop a small molecule that could make immunotherapy available to all cancer patients

Researchers at Tel Aviv University and the University of Lisbon have jointly identified and synthesized a small molecule that could be a more accessible and effective alternative to an antibody that is successfully used to treat a range of cancers. Behind the groundbreaking development is an international team of researchers led by Prof. Ronit Sachi-Fainaro, Head of the Center for Cancer Biology Research and Head of the Laboratory for Cancer Research and Nanomedicine at the Sackler Faculty of Medicine, Tel Aviv University, and Prof. Helena Florindo and Prof. Rita Guedes from the Research Institute for Medicines at the Faculty of Pharmacy, University of Lisbon. The results of the study were published in the Journal for ImmunoTherapy of Cancer.

“In 2018, the Nobel Prize in Medicine was awarded to James Allison and Tasuku Honjo for their contribution to the study of immunotherapy, the treatment of cancer through activation of the immune system,” says Prof. Satchi-Fainaro, a 2020 Kadar Family Award recipient. “Honjo discovered that called T cells express the protein PD-1 that disables the T-cells’ own activity when it binds to the protein PD-L1 expressed in cancer cells. In fact, the interaction between PD-1 and PD-L1 allows cancer cells to paralyze the T cells, preventing them from attacking the cancer cells. Honjo developed antibodies that neutralize either PD-1 or PD-L1, thereby releasing the T cells to fight cancer effectively.”

The antibodies against PD-1/PD-L1 proteins are already approved for and are considered the great promise in the fight against cancer. This immunotherapy can significantly improve patient outcomes, without the that accompany treatments such as chemotherapy. But the antibodies are expensive to produce, and hence not available to all patients. Moreover, the treatment does not affect all parts of the solid tumors because the antibodies are too large to penetrate and reach less accessible and less exposed areas of the tumor. Now, researchers at Tel Aviv University and the University of Lisbon have used bioinformatic and data analysis tools to find a smaller, smarter alternative to these antibodies.

Researchers discover one of the largest known bacteria-to-animal gene transfers inside a fruit fly

A fruit fly genome is not a just made up of fruit fly DNA—at least for one fruit fly species. New research from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) shows that one fruit fly species contains whole genomes of a kind of bacteria, making this finding the largest bacteria-to-animal transfer of genetic material ever discovered. The new research also sheds light on how this happens.

The IGS researchers, led by Julie Dunning Hotopp, Ph.D., Professor of Microbiology and Immunology at UMSOM and IGS, used new genetic long-read sequencing technology to show how genes from the bacteria Wolbachia incorporated themselves into the fly genome up to 8,000 years ago.

The researchers say their findings show that unlike Darwin’s finches or Mendel’s peas, isn’t always small, incremental, and predictable.

Transfusing blood from an old mouse to a younger mouse causes ageing

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Transfusing young mice with blood from older rodents quickly triggers ageing, suggesting that cellular ageing isn’t just a case of wear and tear.

There is a longstanding hypothesis that surgically connecting an old mouse with a young rodent causes a transfer of blood that de-ages the older animal. While this benefits the older mouse, the effects on the young donor rodent were less clear.

To learn more, Irina Conboy at the University of California, Berkeley, and her colleagues transfused blood between young and old mice. Those aged 3 months got blood from animals that were approaching 2 years old.

Scientists Create World’s First Synthetic Embryo!

Scientists Have Created the World’s First Synthetic Embryo with the beginnings of a Brain: 30 Second video.

For the first time ever #scientists have created a #synthetic #embryo using the #stemcell of mice!

Abstract: Journal Cell.
https://www.cell.com/cell/fulltext/S0092-8674(22)00981&#…-149563237

#brain #animals #biology #heart #science #breakthrough #groundbreaking #discovery #israel #research #amazing #doctor #wow #organ #organtransplant