Activities will include experiments, live Q&A with scientists, demonstrations, performances, podcasts, behind-the-scenes tours and more — along with up-to-the-minute information on what researchers are learning about COVID-19.
WOODS HOLE, Mass. — The dialogue between neurons is of critical importance for all nervous system activities, from breathing to sensing, thinking to running. Yet neuronal communication is so fast, and at such a small scale, that it is exceedingly difficult to explain precisely how it occurs. A preliminary observation in the Neurobiology course at the Marine Biological Laboratory (MBL), enabled by a custom imaging system, has led to a clear understanding of how neurons communicate with each other by modulating the “tone” of their signal, which previously had eluded the field. The report, led by Grant F. Kusick and Shigeki Watanabe of Johns Hopkins University School of Medicine, is published this week in Nature Neuroscience.
In 2016 Watanabe, then on the Neurobiology course faculty, introduced students to the debate over how many synaptic vesicles can fuse in response to one action potential (see this 2-minute video for a quick brush-up on neurotransmission). To probe this controversy, they used a “zap-and-freeze” imaging technology conceived by co-authors M. Wayne Davis, Watanabe and Erik Jorgensen, and built by Leica for testing in the Neurobiology course. They zapped a neuron with electricity to induce an action potential, then quickly froze the neuron and took an image. They saw multiple vesicles fusing at once at many synapses, the first novel finding of this Nature Neuroscience report.
Continue reading “Tone of voice matters in neuronal communication” »
It doesn’t appear staff or patient information was compromised.
Health care provider Universal Health Services, one of the largest chains in the US, has been hit by an apparent ransomware attack, TechCrunch reported. UHS facilities in California, Florida, North Dakota, Arizona, and other locations began noticing problems early Sunday, with some locations reporting locked computers and phone systems.
Some UHS hospitals had to use pen and paper to file patient information as a result, according to NBC News.
Continue reading “Ransomware reportedly to blame for outage at US hospital chain” »
Helium is crucial for physics research and medical imaging, but consumer usage of helium balloons threatens supply. Could vacuum balloons save the day?
Researchers in Norway have opened a clinical trial testing the UV1 cancer vaccine in combination with the drugs Opdivo and Yervoy to treat mesothelioma.
SLAC invention uses terahertz radiation to power a miniscule copper accelerator structure.
Particle accelerators generate high-energy beams of electrons, protons and ions for a wide range of applications, including particle colliders that shed light on nature’s subatomic components, X-ray lasers that film atoms and molecules during chemical reactions and medical devices for treating cancer.
As a rule of thumb, the longer the accelerator, the more powerful it is. Now, a team led by scientists at the Department of Energy’s SLAC National Accelerator Laboratory has invented a new type of accelerator structure that delivers a 10 times larger energy gain over a given distance than conventional ones. This could make accelerators used for a given application 10 times shorter.
Researchers identified five unapproved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.approved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.approved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.
It’s no problem atoll
To show that this works, the researchers used a seismometer station on Diego Garcia, a small atoll in the Indian Ocean about 3,000 kilometers from Sumatra. The tectonic plate boundary there is incredibly active, so there’s no shortage of earthquakes to work with. Between 2004 and 2016, there were over 4,000 earthquakes of magnitude 3.0 or higher that occurred near the Nias Island area of Sumatra. The researchers carefully processed all of these events to find repeaters similar enough to do the temperature calculation. They found over 2,000 such pairs based on 900 earthquakes.
If this portion of the Indian Ocean were to warm 1° C, T-waves from those earthquakes would take 5.4 seconds longer to reach this seismometer. The observed changes are smaller than that but they are coherent—there’s both an annual cycle and a gradual warming trend that look similar to other, more traditional datasets.
David Sinclair wants to slow down and ultimately reverse aging. Sinclair sees aging as a disease and he is convinced aging is caused by epigenetic changes, abnormalities that occur when the body’s cells process extra or missing pieces of DNA. This results in the loss of the information that keeps our cells healthy. This information also tells the cells which genes to read. David Sinclair’s book: “Lifespan, why we age and why we don’t have to”, he describes the results of his research, theories and scientific philosophy as well as the potential consequences of the significant progress in genetic technologies.
At present, researchers are only just beginning to understand the biological basis of aging even in relatively simple and short-lived organisms such as yeast. Sinclair however, makes a convincing argument for why the life-extension technologies will eventually offer possibilities of life prolongation using genetic engineering.
Summary: PLCG2-P522R, a genetic variant that protects against Alzheimer’s disease, enhances key functions of immune cells.
Source: University of Eastern Finland
A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer’s disease.
