With more of us living into old age than at any other time, dementia is increasing steadily worldwide, with major individual, family, societal and economic consequences.
Treatment remains largely ineffective and aspects of the underlying pathophysiology are still unclear. But there is good evidence that neurodegenerative diseases —and their manifestation as dementia—are not an inevitable consequence of aging.
Many causes of dementia, including viral infections, are preventable.
Without altering the genetic code in the DNA, epigenetic modifications can change how genes are expressed, affecting an organism’s health and development. The once radical idea that such changes in gene expression can be inherited now has a growing body of evidence behind it, but the mechanisms involved remain poorly understood.
A new study by researchers at UC Santa Cruz shows how a common type of epigenetic modification can be transmitted via sperm not only from parents to offspring, but to the next generation (“grandoffspring”) as well. This is called “transgenerational epigenetic inheritance,” and it may explain how a person’s health and development could be influenced by the experiences of his or her parents and grandparents.
The study, published the week of September 26 in the Proceedings of the National Academy of Sciences (PNAS), focused on a particular modification of a histone protein that changes the way DNA is packaged in the chromosomes. This widely studied epigenetic mark (called H3K27me3) is known to turn off or “repress” the affected genes and is found in all multicellular animals—from humans to the nematode worm C. elegans used in this study.
Robotics and wearable devices might soon get a little smarter with the addition of a stretchy, wearable synaptic transistor developed by Penn State engineers. The device works like neurons in the brain to send signals to some cells and inhibit others in order to enhance and weaken the devices’ memories.
Led by Cunjiang Yu, Dorothy Quiggle Career Development Associate Professor of Engineering Science and Mechanics and associate professor of biomedical engineering and of materials science and engineering, the team designed the synaptic transistor to be integrated in robots or wearables and use artificial intelligence to optimize functions. The details were published Sept. 29 in Nature Electronics.
“Mirroring the human brain, robots and wearable devices using the synaptic transistor can use its artificial neurons to ‘learn’ and adapt their behaviors,” Yu said. “For example, if we burn our hand on a stove, it hurts, and we know to avoid touching it next time. The same results will be possible for devices that use the synaptic transistor, as the artificial intelligence is able to ‘learn’ and adapt to its environment.”
Sept 27 (Reuters) — An experimental Alzheimer’s drug made by Eisai Co Ltd (4523.T) and Biogen (BIIB.O) slowed cognitive and functional decline in a large trial of patients in the early stages of the disease, they said on Tuesday, potentially a rare win in a field littered with failed drugs.
Multiple drugmakers have so far tried and failed to find an effective treatment for the brain-wasting disease that affects about 55 million people globally. A breakthrough would be a major boost to similar studies being run by Roche and Eli Lilly.
Speaking of the Eisai-Biogen drug results announced late on Tuesday night, Ronald Petersen, director of the Mayo Clinic Alzheimer’s Disease Research Center in Rochester, Minnesota said: “It’s not a huge effect, but it’s a positive effect”.
Researchers have used a novel near-infrared light imaging technique to capture the first cross-sectional images of carbon dioxide in the exhaust plume of a commercial jet engine. This new state-of-the-art technology could help accelerate turbine combustion research aimed at developing engines and aviation fuels that are more environmentally friendly.
“This approach, which we call chemical species tomography, provides real-time spatially resolved information for carbon dioxide emissions from a large-scale commercial engine,” said research team leader Michael Lengden from the University of Strathclyde in the U.K. “This information has not been available before at this industrial scale and is a big improvement over the current industry-standard emissions measurement, which involves taking gas from the exhaust to a gas analyzer system in a different location.”
The researchers report the new research in Applied Optics. Chemical species tomography works much like the X-ray-based CT scans used in medicine, except that it uses near-infrared laser light tuned to the absorption wavelength of a target molecule and requires very fast imaging speeds to capture the dynamic processes of combustion.
The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.
Now, researchers from Michigan State University show that in zebrafish and human cell cultures, oxytocin has yet another unsuspected function: It stimulates stem cells derived from the heart’s outer layer (epicardium) to migrate into its middle layer (myocardium) and there develop into cardiomyocytes, muscle cells that generate heart contractions. This discovery could one day be used to promote the regeneration of the human heart after a heart attack. The results are published in Frontiers in Cell and Developmental Biology.
“Here we show that oxytocin, a neuropeptide also known as the love hormone, is capable of activating heart repair mechanisms in injured hearts in zebrafish and human cell cultures, opening the door to potential new therapies for heart regeneration in humans,” said Dr. Aitor Aguirre, an assistant professor at the Department of Biomedical Engineering of Michigan State University, and the study’s senior author.
PHILADELPHIA (CBS) — A newly approved permanent contact lens is growing in popularity, it’s a new alternative for LASIK. No more fumbling with contacts or glasses, now there’s an FDA-approved lens that stays in place, and people say it’s life-changing.
This is the newest implantable contact lens, called EVO.
“It’s absolutely mind-blowing,” patient Rusell Joy said.
Sometimes, it can be hard to follow dietary recommendations despite new dieting ideas and trends.
Everyone’s dietary needs are different, which means that diets often need to be diverse and tailored based on individual needs and health risks.
A recent study published in Gastroenterology looked at diets high in fermentable fiber in mice and their associated risk for developing liver cancer.
Few human injuries are as catastrophic as those to the spine. An accident, disease or act of violence affecting the spine can result in poor function – even paralysis – almost anywhere in the body.
The spinal column is enormously complex, with limited capacity for regeneration and any health implications are usually long-term and chronic.
While there is no known way to repair a spinal cord injury (SCI), scientists may be on the cusp of some important breakthroughs. New approaches are being taken to reverse the nerve damage, with some researchers attempting to reshape the architecture of the spinal cord using materials engineered in the laboratory.