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A research team from Cologne has discovered that a change in the DNA structure—more precisely in the chromatin—plays a decisive role in the recovery phase after DNA damage. The key is a double occupation by two methyl groups on the DNA packaging protein histone H3 (H3K4me2). The discovery was made by scientists under the direction of Prof. Björn Schumacher of the Cluster of Excellence for Aging Research CECAD, the Center for Molecular Medicine Cologne (CMMC), and the Institute for Genome Stability in Aging and Disease at the University of Cologne. The specific change enables genes to be reactivated and proteins to be produced after damage: The cells regain their balance and the organism recovers. The protective role of H3K4me2 was identified in experiments with the nematode Caenorhabditis elegans. The study has now been published in the journal Nature Structural & Molecular Biology.

The genome in every human cell is damaged on a daily basis, for example in the skin by UV radiation from the sun. Damage to the DNA causes diseases such as cancer, influences development, and accelerates aging. Congenital malfunctions in DNA repair can lead to extremely accelerated aging in rare hereditary diseases. Therefore, preservation and reconstruction processes are particularly important to ensure development and to maintain tissue function. DNA, which is rolled up on packaging proteins—the histones—like on cable drums, is regulated by methyl groups. Various proteins are responsible for placing methyl groups on histones or removing them. The number of groups on the packaging proteins affects the activity of genes and thus the protein production of the cell.

Continue reading “Research team discovers mechanism that restores cell function after genome damage” »

A research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking from broken muscle fibers activate “satellite” muscle stem cells. While attempting to identify the proteins that activate satellite cells, they found that metabolic enzymes, such as GAPDH, rapidly activated dormant satellite cells and accelerated muscle injury regeneration. This is a highly rational and efficient regeneration mechanism in which the damaged muscle itself activates the satellite cells that begin the regeneration process.

Skeletal muscle is made up of bundles of contracting muscle fibers and each muscle fiber is surrounded by satellite cells —muscle stem cells that can produce new muscle fibers. Thanks to the work of these satellite cells, muscle fibers can be regenerated even after being bruised or torn during intense exercise. Satellite cells also play essential roles in muscle growth during developmental stages and muscle hypertrophy during strength training. However, in refractory muscle diseases like muscular dystrophy and age-related muscular fragility (sarcopenia), the number and function of satellite cells decreases. It is therefore important to understand the regulatory mechanism of satellite cells in muscle regeneration therapy.

In mature skeletal muscle, satellite cells are usually present in a dormant state. Upon stimulation after muscle injury, satellite cells are rapidly activated and proliferate repeatedly. During the subsequent myogenesis, they differentiate and regenerate muscle fibers by fusing with existing muscle fibers or with together. Of these three steps (satellite cell activation, proliferation, and muscle differentiation), little is known about how the first step, activation, is induced.

August was the second-highest month for sales ever.

Colorado has seen over $1.1 billion in marijuana sales since the COVID-19 pandemic began in this country, according to figures from the state Department of Revenue.

Legal marijuana sales topped $200 million in August for the second month in a row, reaching the second-highest monthly total since recreational sales started in 2014. Counting back to March of this year, when Colorado and the rest of the nation began shutting down over the pandemic, dispensaries have sold over $1.1 billion in marijuana products — and that’s not counting sales in September and October.

Continue reading “Colorado Marijuana Sales Top $1 Billion Since Pandemic Began” »

This will be the 13th New Shepard mission and the 7th consecutive flight for this particular vehicle (a record), demonstrating its operational reusability. N…

Blue Origin successfully completed the 13th New Shepard mission on October 13, 2020. New Shepard flew 12 commercial payloads to space on this mission, including the Deorbit, Descent, and Landing Sensor Demonstration with NASA’s Space Technology Mission Directorate under a Tipping Point partnership. This was the first payload to fly mounted on the exterior of a New Shepard booster rather than inside the capsule, opening the door to a wide range of future high-altitude sensing, sampling, and exposure payloads.

Continue reading “Replay — New Shepard Mission NS-13 Webcast” »

Eli Lilly said Wednesday a monoclonal antibody treatment is effective in reducing levels of the virus that causes Covid-19 in patients, and also appears to prevent patients from visiting the emergency room or hospital.

Lilly had previously released results for a similar treatment using one antibody, which experts viewed as promising. But the new results, of a combination of two antibodies, appear, based on limited data provided in a press release, to be more robust. The results also appear roughly similar to those Regeneron presented last week of its own cocktail of two monoclonal antibodies. Last Friday, President Trump was treated with the Regeneron monoclonal antibodies.

Monoclonal antibodies are synthetic versions of the antibodies that are one of the main weapons of the immune system. Researchers believed that injecting them into patients could help treat them.

There’s no need to fear arsenic poisoning if you grew up in the Argentinian Andes — hundreds of years of drinking arsenic-laced groundwater will have left you with a genetic tolerance for it.

Geneticists from Lund and Uppsala universities had noticed that certain plants and bacteria could live in environments with lots of arsenic, with natural selection favouring a gene known to improve their ability to metabolise the poison. Curious to see if humans could also gain some kind of arsenic immunity, they looked at a group of people who they knew would have been exposed to the poison over many generations — the indigenous peoples of the Argentinian part of the Andes. Sure enough, a higher-than average proportion of people they studied possessed the AS3MT gene, which lets them flush out toxins faster than “normal” people.

The genetic samples tested for the AS3MT gene came from 346 residents of the small, isolated town of San Antonio de los Cobres, located more than 3,700m above sea level in the Andes. Not only does the bedrock in the surrounding area contain a lot of arsenic which gets into the groundwater, but mining operations from the era of Spanish colonisation onwards have released even more arsenic — so both modern people and mummies dating back 7,000 years have had high levels of arsenic found in their hair and internal organs.

Physicists have created a broadband detector of terahertz radiation based on graphene. The device has potential for applications in communication and next-generation information transmission systems, security, and medical equipment. The study came out in ACS Nano Letters.

The new detector relies on the interference of plasma waves. Interference as such underlies many technological applications and everyday phenomena. It determines the sound of musical instruments and causes the rainbow colors in soap bubbles, along with many other effects. The interference of electromagnetic waves is harnessed by various spectral devices used to determine the chemical composition, physical and other properties of objects — including very remote ones, such as stars and galaxies.

Plasma waves in metals and semiconductors have recently attracted much attention from researchers and engineers. Like the more familiar acoustic waves, the ones that occur in plasmas are essentially density waves, too, but they involve charge carriers: electrons and holes. Their local density variation gives rise to an electric field, which nudges other charge carriers as it propagates through the material. This is similar to how the pressure gradient of a sound wave impels the gas or liquid particles in an ever expanding region. However, plasma waves die down rapidly in conventional conductors.

A team of researchers led by Osaka University discovers “microtube implosion,” a novel mechanism that demonstrates the generation of megatesla-order magnetic fields.

Magnetic fields are used in various areas of modern physics and engineering, with practical applications ranging from doorbells to maglev trains. Since Nikola Tesla’s discoveries in the 19th century, researchers have strived to realize strong magnetic fields in laboratories for fundamental studies and diverse applications, but the magnetic strength of familiar examples are relatively weak. Geomagnetism is 0.3−0.5 gauss (G) and magnetic tomography (MRI) used in hospitals is about 1 tesla (T = 10⁴ G). By contrast, future magnetic fusion and maglev trains will require magnetic fields on the kilotesla (kT = 10⁷ G) order. To date, the highest magnetic fields experimentally observed are on the kT order.

Recently, scientists at Osaka University discovered a novel mechanism called a “microtube implosion,” and demonstrated the generation of megatesla (MT = 10¹⁰ G) order magnetic fields via particle simulations using a supercomputer. Astonishingly, this is three orders of magnitude higher than what has ever been achieved in a laboratory. Such high magnetic fields are expected only in celestial bodies like neutron stars and black holes.

Most previous ancient DNA work involves people of European ancestry. A focus of the Emory lab, however, is exploring how environmental changes — including those caused by European contact — affected the biology of Indigenous and other populations of the Americas.

“Our work can connect people to ancestries they potentially don’t know about,” Lindo explains. “It can also give them insights into how historic, and even prehistoric, events may be affecting them today, especially in terms of health risks and disparities.”

Lindo establishes relationships with local and Indigenous people who decide whether unearthed remains from their communities will be analyzed and how the data will be used. Visiting scientists and scholars from these communities will come to the Emory lab, working alongside Emory scientists and students, exchanging knowledge, insights and perspectives.