A Science Immunology analysis of patient samples collected before the #COVID19 pandemic shows that killer #Tcells that can recognize #SARSCoV2, despite never having encountered the virus before, are located in tissues, rather than circulating in blood.
Tissue-resident memory CD8+ T cells in unexposed oropharyngeal lymphoid tissue exhibit specificity for SARS-CoV-2.
After 10,000 years of extinction, one company wants to bring the woolly mammoth back to life.
The biotech firm Colossal raised $15 million in a bid to revive the extinct woolly mammoth by manipulating the DNA of Asian elephants.
A research team from Nanjing University has used cochlear organoids to identify drugs that can promote the regeneration of hair cells. The study, published in Stem Cell Reports, also identifies a signaling pathway as a potential target for hearing restoration.
Hearing is a complex multistep process that allows us to detect sound and involves three key parts of the ear – the outer, middle and inner ear. Sound waves are collected by the pinna of the outer ear and are funneled into the ear canal until they meet the ear drum (tympanic membrane), causing it to vibrate.
The resulting vibrations are transmitted to the ossicles – comprising a chain of three small bones called malleus, incus and stape – located within the middle ear. Movement of the bones transmits the sound vibrations to the inner ear, sending a signal to the cochlea (a hollow spiraling structure filled with fluid). Vibrations cause the fluid within the cochlea to ripple, forming waves that stimulate the movement of hair cells positioned on the top of the basilar membrane that separates the two fluid-filled chambers running along the cochlea.
A company formed by Harvard genetics professor George Church, known for his pioneering work in genome sequencing and gene splicing, hopes to genetically resurrect woolly mammoths.
The story illuminates the way that many scientific discoveries become life-changing innovations: with decades of dead ends, rejections and battles over potential profits, but also generosity, curiosity and dogged persistence against scepticism and doubt. “It’s a long series of steps,” says Paul Krieg, a developmental biologist at the University of Arizona in Tucson, who made his own contribution in the mid-1980s, “and you never know what’s going to be useful”.
Hundreds of scientists had worked on mRNA vaccines for decades before the coronavirus pandemic brought a breakthrough.
Pandemic lockdown forces a new perspective on designs for futuristic AI-based computing devices.
Isaac Newton’s groundbreaking scientific productivity while isolated from the spread of bubonic plague is legendary. University of California San Diego physicists can now claim a stake in the annals of pandemic-driven science.
A team of UC San Diego researchers and colleagues at Purdue University have now simulated the foundation of new types of artificial intelligence computing devices that mimic brain functions, an achievement that resulted from the COVID-19 pandemic lockdown. By combining new supercomputing materials with specialized oxides, the researchers successfully demonstrated the backbone of networks of circuits and devices that mirror the connectivity of neurons and synapses in biologically based neural networks.
Ending the global sanitation crisis — jack sim, founder world toilet organization.
Around 2 billion people worldwide still lack access to the basic tools of improved sanitation (toilets and latrines). One billion people still have to defecate in the open, and at least 10% of the world’s population is thought to consume food irrigated by raw wastewater. An estimated 800,000 children, younger than 5 years of age, perish from diarrhea each year, including conditions related to cholera, dysentery, hepatitis A, typhoid and polio.
Mr. Jack Sim is the Founder of the World Toilet Organization (https://www.worldtoilet.org/), an organization established with the aim to break the taboo around toilets and this global sanitation crisis.
Reducing naturally occurring errors in protein synthesis (production) improves both health and lifespan, finds a new study in simple model organisms led by researchers at UCL and MRC London Institute of Medical Sciences.
The novel findings, published in Cell Metabolism, are the first to demonstrate a direct link between fewer protein mistakes and longevity.
Explaining the study, lead author Dr. Ivana Bjedov (UCL Cancer Institute), said: We commonly hear about DNA mutations, which can cause cancer, and are considered one of the underlying causes of ageing.
In contrast to the energy balance model, the carbohydrate-insulin model makes a bold claim: overeating isn’t the main cause of obesity. Instead, the carbohydrate-insulin model lays much of the blame for the current obesity epidemic on modern dietary patterns characterized by excessive consumption of foods with a high glycemic load: in particular, processed, rapidly digestible carbohydrates. These foods cause hormonal responses that fundamentally change our metabolism, driving fat storage, weight gain, and obesity.
Perspective published in The American Journal of Clinical Nutrition argues the root causes of the obesity epidemic are more related to what we eat rather than how much we eat.
Statistics from the Centers for Disease Control and Prevention (CDC) show that obesity affects more than 40% of American adults, placing them at higher risk for heart disease, stroke, type 2 diabetes, and certain types of cancer. The USDA’s Dietary Guidelines for Americans 2020 – 2025 further tells us that losing weight “requires adults to reduce the number of calories they get from foods and beverages and increase the amount expended through physical activity.”
This approach to weight management is based on the century-old energy balance model which states that weight gain is caused by consuming more energy than we expend. In today’s world, surrounded by highly palatable, heavily marketed, cheap processed foods, it’s easy for people to eat more calories than they need, an imbalance that is further exacerbated by today’s sedentary lifestyles. By this thinking, overeating, coupled with insufficient physical activity, is driving the obesity epidemic. On the other hand, despite decades of public health messaging exhorting people to eat less and exercise more, rates of obesity and obesity-related diseases have steadily risen.
Citicoline, a drug that is naturally found in the body, is commonly used to treat a number of brain injuries and illnesses. For quite some time, doctors have prescribed it for strokes, vascular dementia, Parkinson’s disease, and general aging of the brain. Patients usually see improvement when taking the drug because the body uses it to create and repair cell membranes and lower the presence of free radicals, as noted in the Clinical Interventions in Aging Journal. (Free radicals, which are unstable molecules, can damage cells in the body and are associated with aging and illness.)
Now, researchers from the NYU Grossman School of Medicine have found evidence that citicoline can also be used to treat glaucoma. Normally, glaucoma is treated by removing fluid buildup in the eye, which creates pressure and wears down the cells in the eye and the nerves connecting to the brain. Though monitoring fluid buildup is important, glaucoma can still worsen after the pressure on the eye has been relieved.
