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Category: biotech/medical – Page 1,310

Dr Fossel talking about dementia, telomeres, and clarifying some experimental myths.

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
Program & apply to join: https://foresight.org/biotech-health-extension-program/

Michael Fossel, Telocyte.
Aging: Understanding it, Reversing it.

Michael Fossel is Founder and President of Telocyte. He served as the executive director of the American Aging Association, has published more than 100 articles, books, and chapters on age-related disease and the potential for effective intervention via gene therapy, as well as have served as both an advisor to and board member for several biotechnology companies prior to Telocyte.

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Humans could live until the ripe old age of 150 years according to recent research – and scientists are racing to work out how.

Harvard geniuses, biohackers and internet billionaires are all looking for ways that humans can crack the code on aging.

WaitButWhy blogger Tim Urban writes “the human body seems programmed to shut itself down somewhere around the century mark, if it hasn’t already”.

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Santiago Ramón y Cajal, a Spanish physician from the turn of the 19th century, is considered by most to be the father of modern neuroscience. He stared down a microscope day and night for years, fascinated by chemically stained neurons he found in slices of human brain tissue. By hand, he painstakingly drew virtually every new type of neuron he came across using nothing more than pen and paper. As the Charles Darwin for the brain, he mapped every detail of the forest of neurons that make up the brain, calling them the “butterflies of the brain”. Today, 200 years later, Blue Brain has found a way to dispense with the human eye, pen and paper, and use only mathematics to automatically draw neurons in 3D as digital twins. Math can now be used to capture all the “butterflies of the brain”, which allows us to use computers to build any and all the billons of neurons that make up the brain. And that means we are getting closer to being able to build digital twins of brains.

These billions of neurons form trillions of synapses – where neurons communicate with each other. Such complexity needs comprehensive neuron models and accurately reconstructed detailed brain networks in order to replicate the healthy and disease states of the brain. Efforts to build such models and networks have historically been hampered by the lack of experimental data available. But now, scientists at the EPFL Blue Brain Project using algebraic topology, a field of Math, have created an algorithm that requires only a few examples to generate large numbers of unique cells. Using this algorithm – the Topological Neuronal Synthesis (TNS), they can efficiently synthesize millions of unique neuronal morphologies.

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Through experimentation with a highly promising anti-aging technique, scientists at the UK’s Babraham Institute have demonstrated a new way of turning back the clock in human skin cells. These cells functioned like cells 30 years younger, but in what represents an exciting advance in the field, were able to still retain some of their specialized functions acquired through age.

In 2012, Japanese researcher Shinya Yamanaka earned a Nobel Prize for his work in developing what are known as induced pluripotent stem cells (iPSCs). These start out as regular adult tissue cells that are harvested and exposed to four molecules called Yamanaka factors, which return them to an immature state. From here, the stem cells can theoretically develop into any cell type in the body.

We’ve seen scientists explore this potential in a number of exciting ways, implanting them in rabbits to restore vision, addressing dopamine deficiencies in animal models of Parkinson’s disease and repairing damaged heart muscles in pigs. The full reprogramming process involves subjecting the cells to the Yamanaka factors for around 50 days, but the Babraham scientists have found that shortening this process might bring some significant benefits to the table.

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Findings could lead to targeted approach for treating aging.

Research from the Babraham Institute has developed a method to ‘time jump’ human skin cells by 30 years, turning back the aging clock for cells without losing their specialized function. Work by researchers in the Institute’s Epigenetics research program has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today (April 7, 2022) in the journal eLife and whilst at an early stage of exploration, it could revolutionize regenerative medicine.

What is regenerative medicine?

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A pair of researchers working in the Personal Robotics Laboratory at Imperial College London has taught a robot to put a surgical gown on a supine mannequin. In their paper published in the journal Science Robotics, Fan Zhang and Yiannis Demiris described the approach they used to teach the robot to partially dress the mannequin. Júlia Borràs, with Institut de Robòtica i Informàtica Industrial, CSIC-UPC, has published a Focus piece in the same journal issue outlining the difficulties in getting robots to handle soft material and the work done by the researchers on this new effort.

As researchers and engineers continue to improve the state of robotics, one area has garnered a lot of attention—using robots to assist with health care. In this instance, the focus was on assisting patients in a who have lost the use of their limbs. In such cases, dressing and undressing falls to healthcare workers. Teaching a robot to dress patients has proven to be challenging due to the nature of the soft materials used to make clothes. They change in a near infinite number of ways, making it difficult to teach a robot how to deal with them. To overcome this problem in a clearly defined setting, Zhang and Demiris used a new approach.

The setting was a simulated hospital room with a mannequin lying face up on a bed. Nearby was a hook affixed to the wall holding a surgical gown that is worn by pushing arms forward through sleeves and tying in the back. The task for the robot was to remove the gown from the hook, maneuver it to an optimal position, move to the bedside, identify the “patient” and its orientation and then place the gown on the patient by lifting each arm one at a time and pulling the gown over each in a natural way.

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People could eventually be able to turn the clock back on the cell-ageing process by 30 years, according to researchers who have developed a technique for reprogramming skin cells to behave as if they are much younger.

Research from the Babraham Institute, which is affiliated to the University of Cambridge, could lead to the development of techniques that will stave off the diseases of old age by restoring the function of older cells and reducing their biological age.

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Officials in Tokyo are concerned about the more transmissible BA.2 Omicron coronavirus subvariant, which is increasingly dominant among infections.

The capital’s expert panel says its screening indicates the BA.2 subvariant accounted for nearly 68 percent of new cases in the week through March 28. The rate has climbed nearly 30 points in the past two weeks.

Tohoku Medical and Pharmaceutical University Professor Kaku Mitsuo said, “We are at a critical moment where infections will rapidly spread or not.” He added, “We have to take measures to prevent it from happening.”

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