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Category: biotech/medical – Page 1308

A number of recent studies have homed in on compelling associations between mental health and the microbiome. These insights into strange gut-brain connections have found links between depression and certain species of gut bacteria, and one study even found symptoms of schizophrenia could be transferred from mouse to mouse via fecal transplants.

But are these microbiome perturbations unique to specific psychiatric conditions, or is there a more common gut bacteria signature shared amongst several conditions?

Read more | >

This is the video of Harold Katcher’s presentation to the London Futurists. It was a great discussion, be sure to check it out.

#haroldkatcher #antiaging #rejuvenation #futurism

It has been known for some time that young blood plasma can confer beneficial effects on various organs in mice, although the mechanisms and implications remained unclear. A recent breakthrough experiment is attracting more attention to this area of research: rats treated with a blood plasma mixture known as E5 subsequently had their effective biological age measured by epigenetic clocks, involving 593 tissue samples. The result was a halving of the epigenetic ages of blood, heart, and liver tissue, and a lesser reduction (still statistically significant) in the epigenetic age of the hypothalamus. This has been heralded as the single most dramatic age-reversal experiment in mammals to date.

Continue reading “A paradigm shift in aging research?” | >

SpaceX CEO Elon Musk helped achieve the St. Jude Children’s Research Hospital fundraising goal of the Inspiration4 spaceflight, just hours after his company returned the crew from orbit.

The main goal of the Inspiration4 mission, which launched on Wednesday and splashed down on Saturday, was to raise $200 million for St. Jude.

Inspiration4 commander Jared Isaacman, a billionaire entrepreneur who purchased the flight from SpaceX, donated $100 million personally to St. Jude. The Inspiration4 mission had raised another $60.2 million in donations, before Musk pledged to contribute $50 million himself – pushing the campaign’s total raised to more than $210 million.

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Applying Artificial Intelligence & Machine Learning In Drug Discovery & Design — Dr. Ola Engkvist Ph.D., Head, Molecular AI, Discovery Sciences, R&D, AstraZeneca

Dr. Ola Engkvist is Head of Molecular AI in Discovery Sciences, AstraZeneca R&D (https://www.astrazeneca.com/).

Dr. Engkvist did his PhD in computational chemistry at Lund University followed by a postdoc at Cambridge University.

Continue reading “Dr. Ola Engkvist, Ph.D. — AstraZeneca — Head, Molecular AI, Discovery Sciences, R&D” | >

Thanks to CRISPR, gene therapy and “designer babies” are now a reality. The gene editing Swiss army knife is one of the most impactful biomedical discoveries of the last decade. Now a new study suggests we’ve just begun dipping our toes into the CRISPR pond.

CRISPR-Cas9 comes from lowly origins. It was first discovered as a natural mechanism in bacteria and yeast cells to help fight off invading viruses. This led Dr. Feng Zhang, one of the pioneers of the technology, to ask: where did this system evolve from? Are there any other branches of the CRISPR family tree that we can also harness for gene editing?

In a new paper published last week in Science, Zhang’s team traced the origins of CRISPR to unveil a vast universe of potential gene editing tools. As “cousins” of CRISPR, these new proteins can readily snip targeted genes inside Petri dishes, similar to their famous relative.

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Have to admit this nurse has Kahunas. Not sure I would have the guts to put my arm in that hole.

Shanghai’s first intelligent blood collection robot has started operations at Zhongshan Hospital.

The robot can take the place of a nurse to handle blood sample collection, the hospital said.

The robot will check each person’s blood vessel condition to make an intelligent decision on the position, direction and angle of the needle to ensure safety and accuracy as well as control pain.

Continue reading “Blood collection by robot a Shanghai first” | >

Circa 2012.

A bioengineer and geneticist at Harvard’s Wyss Institute have successfully stored 5.5 petabits of data — around 700 terabytes — in a single gram of DNA, smashing the previous DNA data density record by a thousand times.

The work, carried out by George Church and Sri Kosuri, basically treats DNA as just another digital storage device. Instead of binary data being encoded as magnetic regions on a hard drive platter, strands of DNA that store 96 bits are synthesized, with each of the bases (TGAC) representing a binary value (T and G = 1 A and C = 0).

To read the data stored in DNA, you simply sequence it — just as if you were sequencing the human genome — and convert each of the TGAC bases back into binary. To aid with sequencing, each strand of DNA has a 19-bit address block at the start (the red bits in the image below) — so a whole vat of DNA can be sequenced out of order, and then sorted into usable data using the addresses.

Continue reading “Harvard cracks DNA storage, crams 700 terabytes of data into a single gram” | >