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Category: biotech/medical – Page 1,274

A New Drug Could Treat Type 2 Diabetes

A novel hormone combination has been created by a research team from Helmholtz Munich, the German Center for Diabetes Research (DZD), and Novo Nordisk for the potential treatment of type 2 diabetes in the future. The researchers combined the blood sugar-lowering actions of the medications tesaglitazar and GLP-1 (Glucagon-like peptide-1) to create a new and extremely effective drug.

The benefit of combining Tesaglitazar with GLP-1 is that the Tesaglitazar only penetrates the tissue with GLP-1 receptors. This increases the effects on sugar metabolism while lessening the side effects of tesaglitazar. Scientists have already successfully tested the new drug in animal studies. The study was recently published in the journal Nature Metabolism.

Tesaglitazar enhances glucose and fat metabolism in type 2 diabetic patients. It increases insulin sensitivity by acting on two receptors inside the cell nucleus. This was demonstrated in phase 3 clinical trials. However, tesaglitazar has side effects such as kidney damage.

Normally Taking a Million Years: Scientists Successfully Fuse Chromosomes in Mammals

In nature, evolutionary chromosomal changes may take a million years, but scientists have recently reported a novel technique for programmable chromosome fusion that has successfully created mice with genetic changes that occur on a million-year evolutionary scale in the laboratory. The findings might shed light on how chromosomal rearrangements – the neat bundles of structured genes provided in equal numbers by each parent, which align and trade or mix characteristics to produce offspring – impact evolution.

In a study published in the journal Science, the researchers show that chromosome level engineering is possible in mammals. They successfully created a laboratory house mouse with a novel and sustainable karyotype, offering crucial insight into how chromosome rearrangements may influence evolution.

“The laboratory house mouse has maintained a standard 40-chromosome karyotype — or the full picture of an organism’s chromosomes — after more than 100 years of artificial breeding,” said co-first author Li Zhikun, researcher in the Chinese Academy of Sciences (CAS) Institute of Zoology and the State Key Laboratory of Stem Cell and Reproductive Biology. “Over longer time scales, however, karyotype changes caused by chromosome rearrangements are common. Rodents have 3.2 to 3.5 rearrangements per million years, whereas primates have 1.6.”

AIVITA Biomedical CEO Dr. Hans Keirstead to Deliver Keynote Address at United Nations ‘AI for Good’ Meeting

IRVINE, Calif., Sept. 13, 2022 /PRNewswire/ — AIVITA Biomedical, Inc., a biotech company specializing in innovative cell applications, today announced that chairman and CEO Hans Keirstead, Ph.D., will deliver a keynote address at AI for Good, a program dedicated to achieving the United Nations Sustainable Development Goals through practical AI applications. Details for the keynote are as follows:

Keynote title: AI in healthcare is an infant. Intelligence augmentation is an athlete. When: Wednesday, September 14, 2022, 15:00 CEST (9:00 EDT) Where: Switzerland — Virtual Presentation

The AI for Good meeting is organized by the International Telecommunication Union (ITU), the United Nations specialized agency for information and communication technologies, in partnership with 40 United Nations sister agencies.

Unlocking the power of cell-derived medicines with Dr Alex Schueller, Cellvie’s CEO

The biotech platform that is leveraging one of the cornerstones of evolution – mitochondria.

Mitochondria play a crucial role in the aging process, activating factors and metabolic pathways involved in longevity. Their dysfunction impacts on both lifespan and healthspan, and whilst they have been identified as disease targets for some time, mitochondria have proven difficult to treat.

The founders of cellvie wondered if it were possible, as they put it, to leverage one of the cornerstones of evolution – to replace and augment damaged mitochondria. And so, the concept of Therapeutic Mitochondria Transplantation was born. TMT holds the potential of sustainably affecting mitochondria function, and reinvigorating or amplifying the cellular energy metabolism – and having raised $5 million in Kizoo-led seed funding, cellvie is on the way to turning that possibility into a reality.

Dr Alex Schueller, Cellvie’s CEO, will be speaking at Berlin’s Rejuvenation Startup Summit (14−15 October 2022), as part of an all-star line-up that includes Michael Greve, Eric Verdin, Brian Kennedy, Michael Sidler, Christian Angermayer and our own Phil Newman. Hosted by the Forever Healthy Foundation, this vibrant networking event aims to accelerate the development of the rejuvenation biotech industry.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

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Can we live longer? Physicist makes discovery about telomeres

With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery will help us understand aging and disease.

Physics is not the first scientific discipline that springs to mind at the mention of DNA. But John van Noort from the Leiden Institute of Physics (LION) is one of the scientists who found the new DNA structure. A biophysicist, he uses methods from physics for biological experiments. This also caught the attention of biologists from Nanyan Technological University in Singapore. They asked him to help study the DNA structure of . They have published the results in Nature.

The most powerful laser in the U.S. will have a three-quadrillion-watt maximum output

To begin with, it will only run at a fraction of its eventual three-quadrillion-watt maximum output.

A laser at the University of Michigan, which is set to be the most powerful in the United States, is preparing to send its first laser pulses into an experimental target, a press statement explains.

The laser, named the Zetawatt-Equivalent Ultrashort pulse laser System, or Zeus, will be used to investigate quantum physics as well as outer space. It is hoped studies using the laser will also help to build new technologies in electronics and medicine.

Tech billionaires lost $50 billion as stock prices tumbled on Tuesday

Only two of the top 10 billionaires registered gains.

The world’s top richest people collectively lost $50 billion of their personal fortune as the New York Stock Exchange slumped on Tuesday amidst fears of rising inflation and looming inflation. Elon Musk, Jeff Bezos, Warren Buffet, Google Guys, nobody was spared as prices of stock held by them tumbled, Market Insider.

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Even as most people struggled to balance their work and life during the pandemic, the world’s top billionaires were struck gold and saw their fortunes soar. According to a CBS report in 2021, the first year of the pandemic gave a $4 trillion boost to the billionaires’ wealth, raising the call for a “wealth tax.”

Product: Turn’s proprietary ERA™ Platform enables us to develop tailored therapies for an array of age-associated diseases that affect hundreds of millions of people

In many cases, medicine has found ways to treat the symptoms of these degenerative conditions – such as using analgesics to alleviate osteoarthritis pain or corrective lenses or surgery to improve vision. But medicine still has not found a way to cure the underlying diseases.