All DNA/RNA nucleobases were identified in carbonaceous meteorites. Having been provided to the early Earth as a component in carbonaceous meteorites, these molecules might have played a role for the emergence of genetic functions in early life.
Category: biotech/medical – Page 1178
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A team of international researchers have identified a genetic cause of lupus. Researchers of the study pinpointed that DNA mutations in a gene that senses viral RNA represents one cause of the chronic condition, affecting approximately 1 in 1,000 people living in the UK. It is important to note that this genetic cause is not the sole trigger for everyone affected by lupus.
Researchers of the study sequenced the whole DNA genome of a juvenile systemic lupus erythematosus (JSLE) patient called Gabriela, who was diagnosed with severe lupus at the age of seven. A severe case such as this, with early onset of symptoms, is a rarity and is commonly associated with a single genetic cause, unlike adult-onset lupus.
The researchers that carried out the genetic analysis identified a single point mutation in the Toll Like Receptor 7 (TLR7) gene. Furthermore the researchers discovered other cases of severe lupus where this gene was also mutated.
Earlier this month, we brought you the news that epigenetic reprogramming startup YouthBio Therapeutics had emerged from stealth. The company shed some light on its plans to develop epigenetic reprogramming therapies for age-related diseases by rejuvenating certain cells in our bodies. YouthBio aims to achieve this rejuvenation by developing gene therapies that enable partial cellular reprogramming – an area of longevity science that is now attracting significant commercial interest.
Longevity. Technology: Cellular reprogramming refers to the process of returning adult cells to a “pluripotent” state: blank, embryonic-like cells that can become any cell in the body. This reprogramming can be achieved using techniques based on the discovery of Yamanaka factors.
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In many fields of technology, smaller is better, and machinery is now getting so tiny it’s measured in mere atoms. Researchers at the University of Erlangen–Nuremberg (FAU) in Germany have now developed what they claim are the world’s smallest working gear wheels.
Molecular machines and nanorobots could be extremely useful in the coming decades, helping to construct electronic components, transport drugs through the body, or manipulate individual cells or molecules.
To that end, scientists have developed nanoscale versions of many machine parts, such as motors, pistons, pumps, wrenches and propellers.
Scientists led by Dr. Manuel Serrano have observed symptoms of rejuvenation in the pancreas, liver, spleen, and blood of mice after applying one cycle of cell reprogramming.
To achieve this, the researchers have characterized rejuvenation by studying molecular marks in the DNA, gene expression, and cell metabolism. The study has been published in the journal Aging Cell.
Many diseases, including cancer, are associated with ageing and they are becoming more prevalent as life expectancy increases. Therefore, studying and understanding these processes is crucial if we are to deal with these conditions and also promote healthier aging.
I have created an educational guide to the adenovirus capsid! The adenovirus is one of the most frequently used types of viruses for gene therapy (along with AAV and lentivirus). It is a powerful vehicle for delivering DNA to cells in the body. But to work with adenovirus as a technology, it is important to understand its fundamental biological structure and function. This guide will help you to gain a more holistic comprehension of a particularly important part of adenovirus biology: the capsid. I made the images using PyMol.
PDF version: Guide to the Structure and Function of the Adenovirus Capsid
For this guide, I will explain the fundamental biology of adenovirus capsid proteins with an emphasis on the context of gene therapy. While the guide is meant primarily for readers with an interest in applying adenovirus to gene therapy, it will not include much discussion of the techniques and technologies involved in engineering adenoviruses for such purposes. If you are interested in learning more about adenovirus engineering, you may enjoy my review paper “Synthetic Biology Approaches for Engineering Next-Generation Adenoviral Gene Therapies” [1]. Here, I will focus mostly on the capsid of human adenovirus serotype 5 (Ad5) since it is the most commonly used type of adenovirus employed in gene therapy research, but I will occasionally describe other types of adenoviruses when necessary. Many of the presented concepts remain the same or similar across other types of adenoviruses.
The adenovirus consists of an icosahedral protein capsid enclosing a double-stranded DNA (dsDNA) genome. It possesses 12 fiber proteins which protrude from the capsid and helps to facilitate cellular transduction. Adenoviruses are nonenveloped and approximately 90 nm in diameter (not including the fibers). The Ad5 genome is about 36 kb in size. Major capsid proteins of the adenovirus include the hexon, penton, and fiber. The minor capsid proteins are protein IIIa, protein VI, protein VIII, and protein IX. Inside the capsid, there are core proteins including protein V, protein VII, protein μ (also known as protein X), adenovirus proteinase (AVP), protein IVa2, and terminal protein (TP) [2].
With an aging global population, time is of the essence to find novel targets and therapies for age-related diseases.
Our podcast on the science and technology making the news. This week, we speak to Jennifer Doudna, the Nobel laureate who pioneered the revolutionary tool | Podcasts.
A research team from Osaka University in Japan has concluded that a clinical trial of transplanted IPS cell-derived corneal tissue was safe and effective – further evidence that cellular reprogramming with Yamanaka factors is moving towards scalable therapies.
Longevity. Technology: The clinical trial spanned several years and used corneal tissues derived from induced pluripotent stem cells. The tissue was transplanted into four almost-blind patients, and, according to the research team, none of the patients experienced rejection or tumorigenicity of the transplanted cells and all saw improvements in their symptoms, with three experiencing improved eyesight, with one improving from 0.15 to 0.7. Importantly, all were free of side effects one year later.
IPS cells can be generated from any adult cell, with Yamanaka factors – a group of protein transcription factors from four master genes. These induced stem cells demonstrate the significant quality of pluripotency – they can differentiate into all other cell types of the body. This is incredibly useful both for research and for therapy.