Lifeboat Foundation

A handful of passports are already in the works, including two in Las Vegas. It is not yet clear if any Las Vegas businesses will limit access solely to vaccinated guests.

Las Vegas is no stranger to exclusive VIP lists, but there’s a new way of limiting guest access coming to town: vaccine passports.

These digital credential systems can show whether someone has been vaccinated against COVID-19 and can help businesses limit access to those who have been inoculated. The systems were designed to increase health and safety at various venues, but experts warn of pushback over concerns on privacy and personal choice.

Continue reading “Vaccine passports launched in Las Vegas but privacy, choice still concerns” »

New data from Children’s National Hospital shows parental experience with a number of social determinants of health can ultimately impact brain development in utero, something researchers said should suggest future community health intervention among pregnant people. The data, published in JAMA Network Open, specifically found poorer brain development in fetuses among pregnant people with low socioeconomic status (SES), low educational attainment, and limited employment opportunity.

New data from Children’s National Hospital has found that social determinants of health like income, education, and occupation can impact fetal brain development, following that child into life.

As brain activity-dependent human genes are of great importance in human neuropsychiatric disorders we also examined the expression of these genes to postmortem RNAseq databases from patients suffering from various neurological and psychiatric disorders (Table 1). Datasets were chosen based on similarities in tissue processing and RNAseq methodology to our own protocol. We performed a PCA (Principal Component Analysis) of our fresh brain compared to postmortem brain from healthy, Parkinson’s, Schizophrenia, Huntington’s, and Autism brains for the top 500 brain activity-dependent genes that showed the greatest reduction in the healthy postmortem samples. The PCA revealed a significant separation between the 4 fresh samples and the postmortem samples, independent of whether or not the fresh tissue was from epileptic (high activity, H) or non-epileptic (low activity, L) brain regions (Fig. 2 J). This further demonstrates a selective reduction of activity-dependent genes in postmortem brain independent of whether the underlying tissue is electrically active or not.

The sudden removal of brain tissue from a living person in many ways mimics a catastrophic event that occurs with a hypoxic brain injury or a traumatic death with exsanguination. The human brain has high energy needs, estimated to be 10 times that of other tissues²¹. As a means to understand how the postmortem interval selectively affects some genes and not others in human neocortex, we performed RNAseq and histological analyses in cortical brain tissue as a function of time from 0–24 h at 24 °C in order to simulate a postmortem interval. Neuropathological examination of the tissue used for this study showed a normal-appearing cortical pattern with no histopathologic abnormalities. RNAseq analysis showed a loss of brain activity-dependent genes that were 3-times more prone to be degraded than expected by chance compared to more stable housekeeping genes (Table 2). The threshold to detect activity-dependent genes was related to the probability of being affected by the PMI. The higher the relative expression of the brain activity gene, the more it was enriched in the population of genes affected by the PMI. These findings confirm that genes involved in brain activity are more prone to degradation during the PMI.

One possible explanation for the selective loss of activity-dependent genes could relate to the stability of various cell populations during the simulated PMI. As a means to implicate specific cell populations that could be responsible for the reduction of genes during the simulated PMI we used a clustering algorithm as we have previously described⁹. We found that 1427 genes (71% known brain activity-dependent genes) could be clustered across the seven time points of the simulated PMI. For these clusters, we used AllegroMcode to identify two main clusters. One cluster of 317 rapidly declining genes was predicted to be neuronal and strongly overlapped with the activity-dependent genes. A second cluster of 474 genes was predicted to be glial, including astrocytes and microglia (Fig. 3A). Remarkably, as the neuronal cell cluster rapidly fell, there was a reciprocal and dramatic increase in the expression of the glial cell cluster (Fig. 3B).

Pfizer and BioNTech’s COVID-19 vaccine is 100% effective against the virus in children ages 12 to 15, the companies announced in a press release Wednesday.

In a placebo-controlled trial of 2260 adolescents, none of the participants who received the real vaccine developed COVID-19, the companies said.

In Wednesday’s announcement, StemExpress CEO Cate Dyer said the COVID-19 pandemic created new demand for her company’s expertise. “When the pandemic first hit, we reached out to the federal government and started looking at ways we could help take seven of our laboratories around the United States and start offering COVID testing on a local basis, not only to support nursing homes, but Indian Tribal Communities as well as just the general public.”

PayCertify is a financial technology (FinTech) firm that “encompasses both a complete merchant and consumer experience front to back, pulling analytics and valuable insights to connect data sets in real-time from both the consumer and merchant side of the transaction.”

The two companies are expected to bring a combined 200 biotech and fintech jobs to the region.

SYNTHETIC cells made by combining components of Mycoplasma bacteria with a chemically synthesised genome can grow and divide into cells of uniform shape and size, just like most natural bacterial cells.

In 2016, researchers led by Craig Venter at the J. Craig Venter Institute in San Diego, California, announced that they had created synthetic “minimal” cells. The genome in each cell contained just 473 key genes thought to be essential for life.

For the first time, a team of scientists has created a synthetic single-celled organism that can divide and grow like a regular living cell. This breakthrough could lead to designer cells that can produce useful chemicals on demand or treat disease from inside the body.

This new study, by scientists from the J. Craig Venter Institute (JCVI), the National Institute of Standards and Technology (NIST) and MIT, builds on over a decade’s work in creating synthetic lifeforms. In 2010 a JCVI team created the world’s first cell with a synthetic genome, which they dubbed JCVI-syn1.0.

In 2016, the researchers followed that up with JCVI-syn3.0, a version where the goal was to make the organism as simple as possible. With only 473 genes, it was the simplest living cell ever known – by comparison, an E. coli bacterium has well over 4000 genes. But perhaps it was too simple, because the cells weren’t all that effective at dividing. Rather than uniform shapes and sizes, some of them would form filaments and others wouldn’t fully separate.

‘This means we can start to look at aging as a reversible disease,’ says Prof Shai Efrati; top geriatrician says he is skeptical, and raises concerns.

Ambi Robotics has two flagship products. AmbiSort is a robotic putwall that sorts boxes, polybags, and envelopes from bulk input flow (chutes, totes, and bins) into destination containers (mail sacks, totes). Ambi Robotics claims the system works “over 50% faster than manual labor.” AmbiKit is a robotic system that builds unique kits from any item set. The company said it can be used with subscription boxes, medical kits, gift sets and sample sets for a variety of industries, including cosmetics, food and beverage, consumer goods, medical devices, aerospace and automotive.

The company’s robots are modular, but they do use suction-based gripping. Here’s how AmbiSort works. A depth-sensing camera first looks into a bin of items and analyzes the objects. After determining how to best grasp the item, the robot picks up the item with its suction gripper, holds it up to a barcode scanner, then places the item into a bin. The system then alerts a human operator when a bin is full and ready to be packed.