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Category: biotech/medical – Page 1147

The macula is part of the eye’s retina, which is the light-sensitive tissue mostly composed of the eye’s visual cells: cone and rod photoreceptor cells. The retina also contains a layer called the retinal pigment epithelium (RPE), which has several important functions, including light absorption, cleaning up cellular waste, and keeping the other cells of the eye healthy.

The cells of the RPE also nourish and maintain the eye’s photoreceptor cells, which is why one of the most promising treatment strategies for age-related macular degeneration is to replace aging, degenerating RPE cells with new ones grown from human embryonic stem cells.

Scientists have proposed several methods for converting stem cells into RPE, but there is still a gap in our knowledge of how cells respond to these stimuli over time. For example, some protocols take a few months while others can take up to a year. And yet, scientists are not clear as to what exactly happens over that period of time.

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Rabois’s pushback to remote work comes at a time when many workers are pushing to continue having the option, and companies who allowed it during the pandemic are deciding what their policies will look like moving forward. According to ADP Research Institute, 64% of workers surveyed said they would consider looking for another job if their employer asked them to return full-time.

While Protocol talked to other investors who argued that asking workers to return to the office shouldn’t be a big deal, not everyone agrees, and the debate has spilled over onto Twitter, giving the public a glimpse into how executives and investors view the issue.

In a response to Rabois’s tweet about only funding IRL startups, Jeremy Stoppelmann, cofounder and CEO of Yelp, tweeted that Rabois’s tweet was the “Equivalent to ‘looking to fund startups running Windows95.’”.

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An emerging way to treat diabetes is to repair or replace the cells in the body that naturally produce insulin. Swedish researchers have now identified a molecule that helps stimulate the growth of new insulin-producing cells, and uncovered how it works, opening up new potential diabetes treatments.

Diabetes is characterized by issues with insulin, the hormone that regulates blood glucose levels and allows the body’s cells to access it for energy. In type 1 diabetes, beta cells in the pancreas that normally produce insulin can’t make enough to meet demand, often because those cells have been destroyed by the immune system.

Treatment currently relies on administering insulin shots, but an emerging branch of study centers on finding ways to replenish the insulin production of those beta cells. Previous breakthroughs have included creating artificial beta cells that can pick up the slack, or using stem cells to grow new ones.

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Using retrospective radiocarbon birth dating, an international team of scientists shows that the human liver stays young throughout life and is on average less than three years old.

As one of the major organs of the body, the liver performs many essential biological functions. Almost all the blood in a person’s body passes through the liver, where waste products, worn-out cells, and toxins are filtered. It also produces bile, a solution that helps digest fats and eliminate waste products. Those are just a couple of the major duties it performs — more ore than 500 vital functions have been identified with the liver.

The liver is an essential organ that takes care of detoxifying our bodies. It is prone to injury because it is constantly exposed to toxic substances. To overcome this, the liver has a unique capacity among organs to regenerate itself after damage. Because a lot of the body’s ability to heal and regenerate itself decreases as we age, scientists were wondering if the liver’s capacity to renew also diminishes with age.

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Circa 2020

You’ve no doubt heard of the Large Hadron Collider (LHC), the massive particle accelerator straddling the border between France and Switzerland. The large size of this instrument allows scientists to do cutting-edge research, but particle accelerators could be useful in many fields if they weren’t so huge. The age of room-sized (and larger) colliders may be coming to an end now that researchers from Stanford have developed a nano-scale particle accelerator that fits on a single silicon chip.

Full-sized accelerators like the LHC push beams of particles to extremely high speeds, allowing scientists to study the minutiae of the universe when two particles collide. The longer the beamline, the higher the maximum speed. Keeping these beams confined requires extremely powerful magnets, as well. It all adds up to a bulky piece of equipment that isn’t practical for most applications. For example, cancer radiation treatments with a particle accelerator could be much safer and more effective than traditional methods.

The team from Stanford’s SLAC National Accelerator Laboratory didn’t set out to build something as powerful as an accelerator that takes up a whole room. The chip features a vacuum-sealed tunnel 30 micrometers long and thinner than a human hair. You can see one of the channels above — electrons travel from left to right, propelled by 100,000 infrared laser pulses per second, all of them carefully synchronized to create a continuous electron beam.

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Tel Aviv University researchers have published a new study in Nature outlining how a type of white blood cell can be engineered to secrete anti-human immunodeficiency virus (HIV) antibodies. Based on the results of this study, the team are hopeful that they will be able to produce a one-time medication for acquired immune deficiency syndrome (AIDS) and other diseases.

Gene therapy for HIV

The introduction of treatments such as anti-retroviral therapy (ART) for HIV has helped patients diagnosed with the infection to live longer and healthier lives. Patients are required to take the medicine daily in order to reduce the amount of virus in the body (viral load) so that it is undetectable. If a viral load is undetectable, patients with HIV have effectively zero risk of transmitting the virus. However, a one-time treatment for HIV, which can develop into AIDS, is still desirable to improve HIV patients’ quality of life.

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