Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: biotech/medical – Page 1,128

Increasing studies have reported the therapeutic effect of mesenchymal stem cell (MSC)-derived exosomes by which protein and miRNA are clearly characterized. However, the proteomics and miRNA profiles of exosomes derived from human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs) remain unclear.

In this study, we isolated exosomes from hESCs, hiPSCs, and human umbilical cord mesenchymal stem cells (hUC-MSCs) via classic ultracentrifugation and a 0.22-μm filter, followed by the conservative identification. Tandem mass tag labeling and label-free relative peptide quantification together defined their proteomics. High-throughput sequencing was performed to determine miRNA profiles. Then, we conducted a bioinformatics analysis to identify the dominant biological processes and pathways modulated by exosome cargos. Finally, the western blot and RT-qPCR were performed to detect the actual loads of proteins and miRNAs in three types of exosomes.

Based on our study, the cargos from three types of exosomes contribute to sophisticated biological processes. In comparison, hESC exosomes (hESC-Exos) were superior in regulating development, metabolism, and anti-aging, and hiPSC exosomes (hiPSC-Exos) had similar biological functions as hESC-Exos, whereas hUC-MSCs exosomes (hUC-MSC-Exos) contributed more to immune regulation.

Read more | >

Dr Brian Kennedy on Rejuvant, human longevity trials, aging optimally and why individual response to intervention is key.

Alpha-ketoglutarate (AKG) is used by cells during growth and in healing from injuries; studies have shown it may be effective in treating osteoporosis, preventing a decline in protein synthesis, reducing frailty and, in some mammalian studies; even extending lifespan. has gone one step further, adding calcium to produce LifeAKG™, a patent-pending, highly bioavailable and ultra pure CaAKG supplement, backed by extensive research and double-blind placebo-controlled clinical trials.

Brian Kennedy PhD, who was the Buck Institute’s second CEO, serves as Rejuvant’s Scientific Advisor; he is also a member of the Board. Currently, Dr Kennedy is Professor and Director of the Center for Healthy Aging at the National University of Singapore, and with a plethora of widely-cited papers on aging and longevity under his belt, he is regarded as an expert in the science of gerontology.

Visit Longevity. Technology — https://bit.ly/3PwtH8Y

Follow Longevity. Technology on:
Twitter — https://bit.ly/3AMIXuq.
Facebook — https://bit.ly/3z8H1v5
Instagram — https://bit.ly/3IDvVRX
Linkedin — https://bit.ly/3yIfDmf

Read more | >

Researchers have discovered a new structure of telomeric DNA, which could be key to living longer.

Researchers have discovered a new structure of telomeric DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Read more | >

The real-world applications are limitless.

A group of researchers from the University of Washington has engineered a new AI tool that can identify and design new proteins. This could lead to more efficient vaccines, better cures for cancer, or new materials, according to a report published by MIT Technology Review.

University of Washington scientists have invented an AI tool called ProteinMPNN that allows them to design any proteins they can conceive of. The tool could lead to new cures and new materials.

Read more | >

‘The way it works is similar to how a robotic arm might reach out and clean a surface.’

The future of dental care could have new robotic allies. A group of researchers from the University of Pennsylvania has developed an automated, hands-free oral hygiene system that adapts to the shape of your teeth.

The researchers claim this system can clean teeth more efficiently than the toothbrush and dental floss, according to an article published by the university in July.

Wildpixel/iStock.

A group of researchers from the University of Pennsylvania has developed an automated, hands-free oral hygiene system that adapts to the shape of your teeth.

Read more | >

Join us on Patreon!
https://www.patreon.com/MichaelLustgartenPhD

Quantify Discount Link (At-Home Blood Testing)
https://getquantify.io/mlustgarten.

TruDiagnostic Discount Link (Epigenetic Testing)
CONQUERAGING!
https://bit.ly/3Rken0n.

Bristle Discount Link (Oral microbiome quantification):
ConquerAging15
https://www.bmq30trk.com/4FL3LK/GTSC3/

Cronometer Discount Link (Daily diet tracking):
https://shareasale.com/r.cfm?b=1390137&u=3266601&m=61121&urllink=&afftrack=

Support the channel with Buy Me A Coffee!

Continue reading “Blood Test #5 in 2022: Supplements, Diet” | >

Were you unable to attend Transform 2022? Check out all of the summit sessions in our on-demand library now! Watch here.

Many organizations lack the technology and architecture required to automate decision-making and create intelligent responses across the supply chain, as has been shown by the past few years’ supply chain disruptions. However, these critical breakdowns can no longer be blamed solely on the COVID-19 pandemic. Rather, they can be blamed on businesses’ slow adoption of automated supply chain decision-making, which has resulted in inventory backlogs, price inflation, shortages and more. Further contributing to backlogs is continued single sourcing to one region rather than leveraging distributed regional capabilities. These factors have added to the complexity of systems and the disadvantages of lack of automation and the pandemic brought these existing critical breakdowns into stark relief.

This brings us to today and how this inability to effectively manage data streams is proving debilitating to many companies. In a Gartner study of more than 400 organizations, 84% of chief supply chain officers reported that they could service their customers better with data-driven insights. An equal number of respondents stated that they needed more accurate data in order to predict future conditions and make better decisions.

Read more | >

There was once a time, not so long ago, when scientists like Casey Holliday needed scalpels, scissors and even their own hands to conduct anatomical research. But now, with recent advances in technology, Holliday and his colleagues at the University of Missouri are using artificial intelligence (AI) to see inside an animal or a person—down to a single muscle fiber—without ever making a cut.

Holliday, an associate professor of pathology and anatomical sciences, said his lab in the MU School of Medicine is one of only a handful of labs in the world currently using this high-tech approach.

AI can teach computer programs to identify a in an image, such as a CAT scan. Then, researchers can use that data to develop detailed 3D computer models of muscles to better understand how they work together in the body for motor control, Holliday said.

Read more | >