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Category: biotech/medical – Page 1,112

Scientists have been able to direct a swarm of microscopic swimming robots to clear out pneumonia microbes in the lungs of mice, raising hopes that a similar treatment could be developed to treat deadly bacterial pneumonia in humans.

The microbots are made from algae cells and covered with a layer of antibiotic nanoparticles. The algae provide movement through the lungs, which is key to the treatment being targeted and effective.

In experiments, the infections in the mice treated with the algae bots all cleared up, whereas the mice that weren’t treated all died within three days.

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New research from medical scientists at Johns Hopkins University linked abnormally formed proteins in the human brain with the psychiatric illness called schizophrenia, in a significant number of patients. While they’re not yet sure what the connection is, the study said that deformed proteins were found in the brains of many patients who were diagnosed with schizophrenia.

— contents —

~ story ~ infographic: diagram ~ report ~ by definition ~ infographic: chart ~ learning.

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Summary: Neurons in the memory-associated entorhinal cortex of super-agers are significantly larger than their cognitively average peers, those with MCI, and even in people up to 30 years younger. Additionally, these neurons contained no signs of Tau, a hallmark of Alzheimer’s disease.

Source: Northwestern University.

Neurons in an area of the brain responsible for memory (known as the entorhinal cortex) were significantly larger in SuperAgers compared to cognitively average peers, individuals with early-stage Alzheimer’s disease and even individuals 20 to 30 years younger than SuperAgers — who are aged 80 years and older, reports a new Northwestern Medicine study.

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Based on an analysis of just under half a million records in the UK Biobank, people who drink two to three cups of coffee each day tend to live longer and exhibit less cardiovascular disease compared with those who abstain from the beverage.

While the research doesn’t claim drinking more coffee adds years to your life, it’s nevertheless an intriguing association that scientists are keen to investigate further. It’s also important to weigh the findings against previous studies linking brain shrinkage and an increased risk of dementia with a daily habit of six or more cups of coffee.

“In this large, observational study, ground, instant and decaffeinated coffee were associated with equivalent reductions in the incidence of cardiovascular disease and death from cardiovascular disease or any cause,” says electrophysiologist Peter Kistler, from the Baker Heart and Diabetes Institute in Australia.

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In a discovery with wide-ranging implications, researchers at the University of Massachusetts Amherst recently announced in the Proceedings of the National Academy of Sciences that uniformly charged macromolecules—or molecules, such as proteins or DNA, that contain a large number of atoms all with the same electrical charge—can self-assemble into very large structures. This finding upends our understanding of how some of life’s basic structures are built.

Traditionally, scientists have understood charged polymer chains as being composed of smaller, uniformly charged units. Such chains, called , display predictable behaviors of self-organization in water: They will repel each other because similarly charged objects don’t like to be close to each other. If you add salt to water containing polyelectrolytes, then molecules coil up, because the chains’ electrical repulsion is screened by the salt.

However, “the game is very different when you have dipoles,” says Murugappan Muthukumar, the Wilmer D. Barrett Professor in Polymer Science and Engineering at UMass Amherst, the study’s senior author.

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An interdisciplinary team of University of Minnesota Twin Cities scientists and engineers has developed a first-of-its-kind, plant-inspired extrusion process that enables synthetic material growth. The new approach will allow researchers to build better soft robots that can navigate hard-to-reach places, complicated terrain, and potentially areas within the human body.

The paper is published in the Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed, multidisciplinary, high-impact scientific journal.

“This is the first time these concepts have been fundamentally demonstrated,” said Chris Ellison, a lead author of the paper and professor in the University of Minnesota Twin Cities Department of Chemical Engineering and Materials Science. “Developing new ways of manufacturing are paramount for the competitiveness of our country and for bringing new products to people. On the robotic side, robots are being used more and more in dangerous, remote environments, and these are the kinds of areas where this work could have an impact.”

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