Lifeboat Foundation

New evidence shows that patients with Long COVID syndrome continue to have higher measures of blood clotting, which may help explain their persistent symptoms, such as reduced physical fitness and fatigue.

The study, led by researchers from RCSI University of Medicine and Health Sciences, is published in the Journal of Thrombosis and Haemostasis.

Previous work by the same group studied the dangerous clotting observed in patients with severe acute COVID-19. However, far less is known about Long COVID syndrome, where symptoms can last weeks to months after the initial infection has resolved and is estimated to affect millions of people worldwide.

Widespread pain, a subset of chronic pain associated with musculoskeletal disorders, is linked to an increased risk of all types of dementias, including Alzheimer’s disease, and a greater risk of stroke.

In the study, researchers in the laboratory of Anna Penn, MD, Ph.D., now at Columbia University Vagelos College of Physicians and Surgeons and previously at Children’s National Hospital in Washington, D.C., found that reducing amounts of a single hormone, called allopregnanolone (ALLO), in the placenta caused brain and behavior changes in male offspring that resemble changes seen in some people with autism spectrum disorder. The study also found that both brain structure and behavioral changes in the mice could be prevented with a single injection of ALLO in late pregnancy.

Preterm birth has been shown to increase the risk of autism spectrum disorders and other developmental problems, particularly in males. The more premature a baby is, the greater the risk of either motor or cognitive deficits. What does the preterm baby lose that is so critical to long-term outcomes?

A new study, in mice, suggests that one factor may be the loss of a placental hormone that the developing brain would normally see in the second half of pregnancy.

Continue reading “Loss of placental hormone linked to brain and social behavior changes” »

For the 40-million amputees in need of prosthetic limbs, this personalized and affordable process for fitting prosthetics means hope for a better future.

A new kind of brain-computer interface (BCI) that uses neural implants the size of a grain of sand to record brain activity has been proven effective in rats — and one day, thousands of the “neurograins” could help you control machines with your mind.

Mind readers: BCIs are devices (usually electrodes implanted in the skull) that translate electrical signals from brain cells into commands for machines. They can allow paralyzed people to “speak” again, control robots, type with their minds, and even regain control of their own limbs.

Most of today’s interfaces can listen to just a few hundred neurons — but there are approximately 86 billion neurons in the brain. If we could monitor more neurons, in more places in the brain, it could radically upgrade what’s possible with mind-controlled tech.

Artificial gravity for spaceflight is a concept older than spaceflight itself, but we’ve only ever seen one small scale test ever flown in space. However decades of research have been performed to show that the human body can adapt to the conditions required for rotating artificial gravity. This shows that it’s an engineering problem that likely solvable for interested parties who want to spend the time, effort and money creating the classic rotating space stations from Science Fiction.

Here’s a couple of papers which were heavily referenced in researching this.
https://ntrs.nasa.gov/api/citations/19720019454/downloads/19720019454.pdf.
https://ntrs.nasa.gov/api/citations/19730003384/downloads/19730003384.pdf.

Continue reading “Can The Human Body Handle Rotating Artificial Gravity?” »

The field of neuroprosthetics was around in its earliest stage in the 1950s, but it’s only just starting to show its true potential, with devices that allow amputees to feel and manipulate their surroundings.

A group of researchers from MIT and Shanghai Jiao Tong University, recently collaborated with the goal of making neuroprosthetic hands, which allow users to feel in a more accessible way. The result is an inflatable robotic hand that costs only $500 to build, making it much cheaper than comparable devices, a post from MIT reveals.

Continue reading “New Inflatable Low-Cost Prosthetic Allows Users to Feel” »

Human induced pluripotent stem cells (iPSCs) can be used to generate brain organoids containing an eye structure called the optic cup, according to a study published today in the journal Cell Stem Cell.

“So many genes are involved in DNA maintenance, FOXO3 for example, which is very interesting, but it cannot be a therapeutic target because it will trigger a lot of other things,” he explains. “SIRT6 is coding for only one protein and, because it’s a small protein, the cargo size is not too big and it can be easily delivered into cells, so it’s possible to use it as a gene therapy target.”

Some of the other factors that play in Genflow’s favour, says Leire, are that the world has reached a better understanding of the biology of aging, but also that gene therapy has also progressed well over the years.