The ability to detect imminent threats and execute behaviors aimed at protecting oneself, such as hiding, running away or defending oneself, is central to the survival of most animal species. A region of the mammalian brain known to play a key role in threat response is the hypothalamus, which also regulates the release of hormones and other vital bodily functions.
Researchers at California Institute of Technology (Caltech) and Howard Hughes Medical Institute recently carried out a study aimed at better understanding how a specific group of neurons in the mouseventromedial hypothalamus dorsomedial subdivision (VMHdm), which are identified by the presence of the steroidogenic factor 1 (SF1) gene, contribute to the coding of predator imminence.
Their findings, published in Neuron, show that distinct subsets of VMHdmSF1 neurons encode multiple internal states that are evoked by the imminence of predators.
Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have developed a technique that could help advance treatments in tissue engineering. The study, published in the journal Small, introduces a technique for producing tissues with precise cellular organization designed to mimic the natural structure of human tissue.
Using a simple light-based 3D printing method, the team created microgels with controlled internal architectures. These structures help guide how cells behave and grow, mimicking the way cells naturally behave in the body.
By adjusting properties of light as it interacts with hydrogels, the team modified the internal structure of these microgels, enabling precise control of cell organization in 3D space. This breakthrough addresses a major challenge in creating realistic, functional tissue environments critical for tissue repair and regeneration.
Imagine a T-shirt that could monitor your heart rate or blood pressure. Or a pair of socks that could provide feedback on your running stride. It may be closer than you think, with new research from Washington State University demonstrating a particular 3D ink printing method for so-called smart fabrics that continue to perform well after repeated washings and abrasion tests. The research, published in the journal ACS Omega, represents a breakthrough in smart fabric comfort and durability, as well as using a process that is more environmentally friendly.
Hang Liu, a textile researcher at WSU and the corresponding author of the paper, said that the bulk of research in the field so far has focused on building technological functions into fabrics, without attention to the way fabrics might feel, fit, and endure through regular use and maintenance, such as washing.
“The materials used, or the technology used, generally produce very rigid or stiff fabrics,” said Liu, an associate professor in the Department of Apparel, Merchandising, Design and Textiles. “If you are wearing a T-shirt with 3D printed material, for example, for sensing purposes, you want this shirt to fit snugly on your body, and be flexible and soft. If it is stiff, it will not be comfortable and the sensing performance will be compromised.”
Just 10 to 15 minutes of mindfulness practice a day led to reduced stress and anxiety for autistic adults who participated in a study led by scientists at MIT’s McGovern Institute for Brain Research. Participants in the study used a free smartphone app to guide their practice, giving them the flexibility to practice when and where they chose.
Mindfulness is a state in which the mind is focused only on the present moment. It is a way of thinking that can be cultivated with practice, often through meditation or breathing exercises—and evidence is accumulating that practicing mindfulness has positive effects on mental health. The open-access study, reported April 8 in the journal Mindfulness, adds to that evidence, demonstrating clear benefits for autistic adults.
“Everything you want from this on behalf of somebody you care about happened: reduced reports of anxiety, reduced reports of stress, reduced reports of negative emotions, and increased reports of positive emotions,” says McGovern investigator and MIT Professor John Gabrieli, who led the research with Liron Rozenkrantz, an investigator at the Azrieli Faculty of Medicine at Bar-Ilan University in Israel and a research affiliate in Gabrieli’s lab.
A method is developed for expressing large dystrophins to enhance muscle function in mouse models of muscular dystrophy, with potential clinical benefits for numerous disorders caused by mutations in large genes that exceed the adeno-associated virus capacity.
Biomarkers used to predict heart failure risk in the general population may be ineffective for assessing risk after pregnancies complicated by hypertension or diabetes, according to a study published in JAMA Cardiology.
Several adverse pregnancy outcomes, including preeclampsia and gestational diabetes, have been linked to long-term heart health risks for pregnant women, said Priya Freaney, MD, ‘22 GME, assistant professor of Medicine in the Division of Cardiology, who was first author of the study.
“We know that features of complicated pregnancies can impact a woman’s heart disease risk decades later,” Freaney said. “It’s important for us to have some way to track and screen the patients that have pregnancy complications to further clarify if someone’s on a high-risk path toward heart disease and help bring their risk down with aggressive screening, prevention or early implementation of therapies.”
Organoids, a ‘new approach methodology’, could forecast how drug candidates perform and help developers make informed decisions, by offering insights into toxicology and personalized medicine.
New findings in Nature reveal how age-related gut changes fuel the growth of pre-leukemic blood cells. Scientists at Cincinnati Children’s along with an international team of researchers have discovered a surprising new connection between gut health and blood cancer risk — one that could transform how we think about aging, inflammation, and the early stages of leukemia.
As we grow older — or in some cases, when gut health is compromised by disease — changes in the intestinal lining allow certain bacteria to leak their byproducts into the bloodstream. One such molecule, produced by specific bacteria, acts as a signal that accelerates the expansion of dormant, pre-leukemic blood cells, a critical step to developing full-blown leukemia.
The team’s findings — published April 23, 2025, in the journal Nature — lay out for the first time how this process works. The study also suggests that this mechanism may reach beyond leukemia to influence risk for other diseases and among older people who share a little-known condition called clonal hematopoiesis of indeterminate potential (CHIP).
On this mind-bending episode of Impact Theory, Tom Bilyeu sits down with Ben Lamm, the visionary entrepreneur behind Colossal Biosciences, to explore a world that sounds straight out of science fiction—yet is rapidly becoming our reality. Together, they pull back the curtain on the groundbreaking technology making de-extinction not only possible, but increasingly practical, from resurrecting woolly mammoths and dire wolves to saving endangered species and unraveling the secrets of longevity.
Ben explains how CRISPR gene editing has unlocked the power to make precise DNA changes—editing multiple genes simultaneously, synthesizing entirely new genetic blocks, and pushing the limits of what’s possible in biology and conservation. The conversation dives deep into the technical hurdles, ethical questions, and the unexpected magic of re-engineering life itself, whether it’s creating hairier, “woolly” mice or tackling the colossal challenge of artificial wombs and universal eggs.
But this episode goes way beyond Jurassic Park fantasies. Tom and Ben debate the future of human health, gene selection through IVF, the specter of eugenics, global competition in biotechnology, and how AI will soon supercharge the pace of biological engineering. They even touch on revolutionary solutions to our plastic crisis and what it means to inspire the next generation of scientists.
Get ready to have your mind expanded. This is not just a podcast about bringing back extinct creatures—it’s a deep dive into the next frontiers of life on Earth, the technologies changing everything, and the choices we’ll face as architects of our own biology. Let’s get legendary.
