Lifeboat Foundation

Nature uses 20 canonical amino acids as building blocks to make proteins, combining their sequences to create complex molecules that perform biological functions.

But what happens with the sequences not selected by nature? And what possibilities lie in constructing entirely new sequences to make novel (de novo) proteins bearing little resemblance to anything in nature?

Continue reading “Chemists create quantum dots at room temperature using lab-designed protein” »

In the underground movement known as, people are taking their health into their own hands. Biohacking ranges from people making simple lifestyle changes to extreme body modifications.

One popular form of focuses on nutrigenomics, where biohackers study how the foods they eat affect their genes over time. They believe they can map and track the way their diet affects genetic function. They use dietary restrictions and blood tests, while tracking their moods, energy levels, behaviors, and cognitive abilities.

Continue reading “I got a chip implanted in a biohacking garage” »

A biological mechanism has been identified by researchers at Linköping University in Sweden that increases the strength with which fear memories are stored in the brain The research, conducted in rats, was published in the scientific journal Molecular Psychiatry. It provides new insights into the processes behind anxiety-related disorders and identified shared mechanisms of anxiety and alcohol dependence.

The ability to feel fear is critical for escaping life-threatening circumstances and learning how to avoid them in the future. However, in certain conditions, such as post-traumatic stress disorder (PTSD

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that develops in some people who have experienced or witnessed a shocking, scary, or dangerous event.

Avi Shporer, Research Scientist, with the MIT Kavli Institute for Astrophysics and Space Research via Chris Adami, Paul Davies, AIP Advances, EurekaAlert and University of Portsmouth

“Information,” wrote Arizona State University astrophysicist Paul Davies in an email to The Daily Galaxy, “is a concept that is both abstract and mathematical. It lies at the foundation of both biology and physics.”

Continue reading “Is Information the Fifth State of Matter in the Universe?” »

A Dyson Sphere is a megastructure that has not yet been built. Scientists conceive of it as a giant shell that encloses the sun.

Hypothetically, the Dyson Sphere will be lined with mirrors and solar panels that will collect the energy from the sun. This would be an unimaginable amount of energy.

In theory, the Dyson Sphere would be large enough that it could be a habitable place for humans and it would act as an artificial biosphere in the case that Earth’s supplies have dwindled. It would be a way to ensure survival for the human race.

The concept of ‘anti-realism’ is widely seen as a fact of life for many physicists studying the mysterious effects of quantum mechanics. However, it also seems to contradict the assumptions of many other fields of research. In his research, Dr William Sulis at McMaster University in Canada explores the issue from a new perspective, by using a novel mathematical toolset named the ‘process algebra model’. In suggesting that reality itself is generated by interacting processes more fundamental than quantum particles, his theories could improve researchers’ understanding of fundamental processes in a wide variety of fields.

The concept of ‘locality’ states that objects and processes can only be influenced by other objects and processes in their immediate surroundings. It is a fundamental aspect of many fields of research and underpins all of the most complex systems we observe in nature, including living organisms. “Biologists and psychologists have known for centuries that the physical world is dominated by processes which are characterized by factors including transformation, interdependence, and information”, Dr Sulis explains. “Organisms are born, develop, continually exchange physical components and information with their environment, and eventually die.”

Beyond biology, the principle of locality also extends to Einstein’s theory of special relativity. Since the speed of light sets a fundamental speed limit on all processes in the universe, the theory states that no process can occur if it has not been triggered by another event in its past, at a close enough distance for light to travel between them within the time separating them. In general, these theories are unified by a concept which physicists call ‘realism’. Yet despite this seemingly intuitive rule, physicists have increasingly come to accept the idea that it doesn’t present a full description of how all processes unfold.

Biological supramolecular assemblies, such as phospholipid bilayer membranes, have been used to demonstrate signal processing via short-term synaptic plasticity (STP) in the form of paired pulse facilitation and depression, emulating the brain’s efficiency and flexible cognitive capabilities. However, STP memory in lipid bilayers is volatile and cannot be stored or accessed over relevant periods of time, a key requirement for learning. Using droplet interface bilayers (DIBs) composed of lipids, water and hexadecane, and an electrical stimulation training protocol featuring repetitive sinusoidal voltage cycling, we show that DIBs displaying memcapacitive properties can also exhibit persistent synaptic plasticity in the form of long-term potentiation (LTP) associated with capacitive energy storage in the phospholipid bilayer. The time scales for the physical changes associated with the LTP range between minutes and hours, and are substantially longer than previous STP studies, where stored energy dissipated after only a few seconds. STP behavior is the result of reversible changes in bilayer area and thickness. On the other hand, LTP is the result of additional molecular and structural changes to the zwitterionic lipid headgroups and the dielectric properties of the lipid bilayer that result from the buildup of an increasingly asymmetric charge distribution at the bilayer interfaces.

Researchers at the Department of Energy’s Oak Ridge National Laboratory, the University of Tennessee and Texas A&M University demonstrated bio-inspired devices that accelerate routes to neuromorphic, or brain-like, computing.

Results published in Nature Communications report the first example of a lipid-based “memcapacitor,” a charge storage component with memory that processes information much like synapses do in the brain. Their discovery could support the emergence of computing networks modeled on biology for a sensory approach to machine learning.

“Our goal is to develop materials and computing elements that work like biological synapses and neurons—with vast interconnectivity and flexibility—to enable autonomous systems that operate differently than current computing devices and offer new functionality and learning capabilities,” said Joseph Najem, a recent postdoctoral researcher at ORNL’s Center for Nanophase Materials Sciences, a DOE Office of Science User Facility, and current assistant professor of mechanical engineering at Penn State.

While studying how bio-inspired materials might inform the design of next-generation computers, scientists at the Department of Energy’s Oak Ridge National Laboratory achieved a first-of-its-kind result that could have big implications for both edge computing and human health.

Results published in Proceedings of the National Academy of Sciences show that an artificial cell membrane is capable of long-term potentiation, or LTP, a hallmark of biological learning and memory. This is the first evidence that a cell membrane alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL.