“We want to build tools that can make biology programmable,” says Alex Rives, the company’s chief scientist, who was part of Meta’s efforts to apply AI to biological data.
EvolutionaryScale’s AI tool, called ESM3, is what’s known as a protein language model. It was trained on more than 2.7 billion protein sequences and structures, as well as information about these proteins’ functions. The model can be used to create proteins to specifications provided by users, akin to the text spit out by chatbots such as ChatGPT.
“It’s going to be one of the AI models in biology that everybody’s paying attention to,” says Anthony Gitter, a computational biologist at the University of Wisconsin–Madison.
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report the 3D imaging of a suspended nanostructure. The technique used is an extension of atomic force microscopy and is a promising approach for visualizing various 3D biological systems.
Atomic force microscopy (AFM) was originally invented for visualizing surfaces with nanoscale resolution. Its basic working principle is to move an ultrathin tip over a sample’s surface. During this xy-scanning motion, the tip’s position in the direction perpendicular to the xy-plane follows the sample’s height profile, resulting in a height map of the surface.
In recent years, ways to extend the method to 3D imaging have been explored, with researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University reporting pioneering experiments on living cells. However, for 3D-AFM to evolve into a widely applicable technique for visualizing flexible molecular structures, a thorough understanding of the imaging mechanisms at play is necessary.
Editor’s note: Video above is about a NASA astronaut discussing an extended stay in space.
(THE CONVERSATION) – Only about 600 people have ever traveled to space. The vast majority of astronauts over the past six decades have been middle-aged men on short-duration missions of fewer than 20 days.
Today, with private, commercial and multinational spaceflight providers and flyers entering the market, we are witnessing a new era of human spaceflight. Missions have ranged from minutes, hours and days to months.
A new feature story out on book Transhuman Citizen:
A former presidential candidate who believes a dramatic increase in science funding can help humans achieve biological immortality has told Newsweek he is considering a third White House run in 2028.
Zoltan Istvan ran as an independent candidate during the 2016 presidential election when he attracted widespread media attention for driving a bus modified to look like a coffin from San Francisco to Washington D.C., to illustrate his believe that death can be overcome.
In 2019 he challenged Trump for the Republican presidential nomination using the campaign motto “Upgrading America,” in what he admitted was primarily a stunt to increase conservative interest in his ideas.
Istvan is part of the global transhumanist movement of people who want to use emerging technology such as artificial intelligence to radically enhance human capabilities. Many transhumanists believe humans will eventually achieve biological immortality, meaning people will no longer die from illness or old age, and could potentially have their minds uploaded to computers and live virtually.
WASHINGTON — The National Aeronautics and Space Administration (NASA) has announced that the agency is seeking assistance from industry as it begins a study into its Geostationary Littoral Imaging and Monitoring Radiometer (GLIMR) Access to Space (ATS) approach.
The GLIMR mission aims to provide transformative rapid observations of dynamic coastal zone ecosystems throughout the Gulf of Mexico (GoM) and coastal continental U.S. (CONUS). Its goal is to observe and monitor ocean biology, chemistry, and ecology to help protect ecosystem sustainability, improve resource management, and enhance economic activity. This includes identifying and tracking harmful algal blooms and oil spills, while also observing, quantifying, and understanding processes associated with rapid changes in phytoplankton growth.
The GLIMR ATS scope is expected to include several key components and activities: the spacecraft itself, the launch vehicle, the integration and testing of the GLIMR payload with the spacecraft, and the integration of the spacecraft with the launch vehicle and subsequent launch. It will also cover the command uplink from the industry-provided Mission Operations Center (MOC), the downlink of GLIMR engineering and science telemetry to industry-allocated ground stations, and the delivery of error-checked GLIMR data to various mission partners. Additionally, it encompasses all related tasks and support required during the planned GLIMR Mission, such as pre-launch planning, launch support, in-orbit check-out, and operations.
New research identifies the molecule KIBRA as a critical “glue” in stabilizing long-term memories by maintaining synaptic strength, offering insights into memory persistence despite ongoing cellular changes.
Whether it’s a first-time visit to a zoo or when we learned to ride a bicycle, we have memories from our childhoods kept well into adult years. But what explains how these memories last nearly an entire lifetime?
A new study in the journal Science Advances, conducted by a team of international researchers, has uncovered a biological explanation for long-term memories. It centers on the discovery of the role of a molecule, KIBRA, that serves as a “glue” to other molecules, thereby solidifying memory formation.
Want to join the debate? Check out the Intelligence Squared website to hear about future live events and podcasts: http://www.intelligencesquared.com. __________________________
How come there are conscious minds? How do language and culture evolve? Should we still teach children things which computers can do better? Will our smart electronic devices rob us of our intelligence? Will human intelligence and AI co-evolve?
These are some of the intriguing questions that Daniel Dennett, one of the most influential and provocative thinkers of modern times, sought to answer when he came to the Intelligence Squared stage to discuss his lifetime’s work on the evolution of the human mind. Dennett’s cross-disciplinary approach – encompassing neuroscience, evolutionary biology and artificial intelligence – has been widely acclaimed and helped redefine the role of the philosopher for our age.
In this exclusive event, Dennett explored the major themes of his forthcoming book, ‘From Bacteria to Bach and Back’, including how our minds came into existence, how our brains work, and how ideas are culturally transmitted. He exploded many of the notions we take for granted about how we think – such as the idea of the individual – offering instead a bold new explanation of human consciousness which views it largely as a product of cultural evolution built up over millennia.
Sharing the stage with Dennett were key figures from the next generation of scientists, AI experts, philosophers and artists, with whom he will engage on what it means to be human.
Adenosine-to-inosine editing is a form of RNA modification observed in the human brain transcriptome. Here the authors question the accuracy of utilizing postmortem samples to reflect the RNA biology of living brains. This is due to significant differences in adenosine-to-inosine editing between living and postmortem brain tissues, with most sites exhibiting higher editing levels postmortem.
In this episode of the 5th Industrial Revolution VODcast we sit down with Dr. Jordan Okie of Arizona State University School of Earth and Space Exploration to discuss a key relevancy to the next industrial revolution, sustainability, through the lens of Dr. Okie’s area of expertise: Ecology and Biology. Our key takeaways: We are in a race against time and extinction. We will need to find a way to evolve through technology to survive, be it here on Earth or in our exploration of Space.
Johns Hopkins research sheds new light on how mammals track their position and orientation while moving, revealing that visual motion cues alone allow the brain to adjust and recalibrate its internal map even in the absence of stable visual landmarks.
Their results are published in Nature Neuroscience.
“When you move through space, you have a lot of competing sensory information telling you where you are and how fast you are going, and your brain has to make sense of that,” said study co-leader Noah Cowan, professor of mechanical engineering at the Whiting School of Engineering and director of the Locomotion in Mechanical and Biological Systems (LIMBS) Laboratory.
