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How gravity causes a perfectly spherical ball to roll down an inclined plane is part of the elementary school physics canon. But the world is messier than a textbook.
Scientists in the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have sought to quantitatively describe the much more complex rolling physics of real-world objects. Led by L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics, Physics, and Organismic and Evolutionary Biology in SEAS and FAS, they combined theory, simulations, and experiments to understand what happens when an imperfect, spherical object is placed on an inclined plane.
Published in Proceedings of the National Academy of Sciences, the research, which was inspired by nothing more than curiosity about the everyday world, could provide fundamental insights into anything that involves irregular objects that roll, from nanoscale cellular transport to robotics.
Want to restore the planet’s ecosystems and see your impact in monthly videos? The first 200 people to join Planet Wild with my code SABINE23 will get the first month for free at https://planetwild.com/r/sabinehossen…
If you want to get to know them better first, check out their latest mission, where they go on to Kenya to find a more peaceful solution for the coexistence of lions and farms. https://planetwild.com/r/sabinehossen…
Last month, DARPA published a call for proposals on how to “grow” massive biological structures in space. It’s not as crazy as it sounds: The space race is heating up outside of the weird space biology sector. Some startups are building self-assembling space habitats, others are working on spaceports, and the ISS’s successor is in development. Let’s take a look.
The DARPA Call: https://sam.gov/opp/426e5868fcf74dd4a…
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Researchers from the German Primate Center—Leibniz Institute for Primate Research and the Max Planck Institute of Molecular Cell Biology and Genetics have discovered two specific genes that evolve exclusively in humans jointly influence the development of the cerebrum. They have thus provided evidence that these genes contribute together to the evolutionary enlargement of the brain.
The work has been published in Science Advances.
The results show that the two genes act in a finely tuned interplay: one ensures that the progenitor cells of the brain multiply more, while the other causes these cells to transform into a different type of progenitor cell—the cells that later form the nerve cells of the brain. In the course of evolution, this interplay has led to the human brain being unique in its size and complexity.
Additionally, the quantum computing cloud service offered by the University of Osaka has begun integrating OQTOPUS into its operations and Fujitsu Limited will make it available for research partners using its quantum computers in the second half of 2025.
Moving forward, the research team will drive the advancement of quantum computing through the continuous expansion of OQTOPUS’s capabilities and the development of a thriving global community. Dr. Keisuke Fujii at the Center for Quantum Information and Quantum Biology (QIQB) of The University of Osaka mentions, “this will facilitate the standardization of various quantum software and systems while driving the creation of innovative quantum applications.”
The research was funded by the Japan Science and Technology Agency and the National Institutes for Quantum Science and Technology.
Inspired by biological cells, the robots are made of water encased in Teflon armor and are each about the size of a grain of rice.
In the desert areas of Namibia, Oman, and Saudi Arabia, research work has revealed unusual structures that are probably due to the activity of an unknown microbiological life form. Unusually small burrows, i.e., tiny tubes that run through the rock in a parallel arrangement from top to bottom, were discovered in marble and limestone of these desert regions. “We were surprised because these tubes are clearly not the result of a geological process,” said Professor Cees Passchier from Johannes Gutenberg University Mainz (JGU), who first came across the phenomenon during geological field work in Namibia. During subsequent sample investigations, evidence of biological material was found. Evidently, microorganisms had perforated the rock. “We don’t currently know whether this is a life form that has become extinct or is still alive somewhere,” added Passchier.
Puzzling discovery in Namibia
Geologist Cees Passchier has been working in Namibia for 25 years, among other places. His research focuses on the geological reconstruction of Precambrian terranes. “We look at the structure of the rocks to find out how continents came together to form the supercontinent Gondwana 500 to 600 million years ago,” explained Passchier. At that time, carbonate deposits formed in the ancient oceans and turned into marble due to pressure and heat. “We noticed strange structures in this marble that were not the result of geological events.” Instead of smooth erosion surfaces, tubes could be seen that were about half a millimeter wide and up to three centimeters long, lined up parallel to one another and forming bands up to ten meters long. Some calcrete crusts had formed on the edges.
The emergence of the new pathogen SARS-CoV-2 determined a rapid need for monoclonal antibodies (mAbs) to detect the virus in biological fluids as a rapid tool to identify infected individuals to be treated or quarantined. The majority of commercially available antigenic tests for SARS-CoV-2 rely on the detection of N antigen in biologic fluid using anti-N antibodies, and their capacity to specifically identify subjects infected by SARS-CoV-2 is questionable due to several structural analogies among the N proteins of different coronaviruses. In order to produce new specific antibodies, BALB/c mice were immunized three times at 20-day intervals with a recombinant spike (S) protein. The procedure used was highly efficient, and 40 different specific mAbs were isolated, purified and characterized, with 13 ultimately being selected for their specificity and lack of cross reactivity with other human coronaviruses. The specific epitopes recognized by the selected mAbs were identified through a peptide library and/or by recombinant fragments of the S protein. In particular, the selected mAbs recognized different linear epitopes along the S1, excluding the receptor binding domain, and along the S2 subunits of the S protein of SARS-CoV-2 and its major variants of concern. We identified combinations of anti-S mAbs suitable for use in ELISA or rapid diagnostic tests, with the highest sensitivity and specificity coming from proof-of-concept tests using recombinant antigens, SARS-CoV-2 or biological fluids from infected individuals, that represent important additional tools for the diagnosis of COVID-19.
