Bioengineering – Lifeboat News: The Blog

Jun 23
2016

How molecules can do statistics

Mobile phones have become commonplace. Modern communication devices like mobile phones need to exchange huge amounts of information. However, what is hidden underneath the elegantly shaped plastic casings is quickly forgotten: Complex signal processors constantly fighting against noise and steadily adapting themselves to changing environment.

But noise and changing environmental conditions do not only affect electrical circuits. In synthetic biology scientists are facing similar problems. However, in synthetic biology a methodology to deal with noise does not exist yet. Prof. Mustafa Khammash and Christoph Zechner of the Department of Biosystems Science and Engineering have studied how conventional signal processors can be translated into biochemical processes — built and operated inside living cells.

A major limitation in engineering biological circuits is that host cells — even if they are genetically identical — are never the same. For instance, cell A might be in a different cell-cycle stage or have more ribosomes available than cell B. Therefore, the same synthetic circuit may behave very differently in each of these two cells. In extreme cases, only a small fraction of cells might show the correct behavior, while the remaining cells act unpredictably. This is referred to as context-dependency.

Jun 23
2016

Scientific Innovation Needs the European Union to Succeed

My new Psychology Today story on BREXIT and the EU:

Scientific innovation doesn’t just happen on its own. It takes stable economies, free societies, and open-minded governments. The best environment for science to thrive in is that of collaborating groups incentivized to communicate and cooperate with one another. This is precisely what the European Union is.

And now, more than ever, the union of Europe is needed—because we are crossing over into the transhumanist age, where radical science and technology will engulf our lives and challenge our institutions. Robots will take 75% of the jobs in the next 25 years. CRISPR gene editing technology will allow us to augment our intelligence, perhaps doubling our IQ. Bionic organs will stave off death, allowing 200 year lifespans.

The science and technology coming in just the next two decades will cause unprecedented challenges to humanity. Most of the world will get chip implants— I have one —to assist with quick payments, emergency tracking, and to replace archaic accessories like car keys. We’ll also all use genetic therapies to cure cancer, heart disease, Alzheimer’s, and even aging. And robots will be ubiquitous—driving us everywhere, homeschooling our children, and maybe even becoming preferred sexual partners.

Jun 22
2016

Approved: First Ever Human Trials Involving CRISPR Gene Editing

Excellent!!! Cannot wait until we eradicate cancer, MS, Parkinson, Dystonia, Cystic-Fibrosis, LGD, etc.

A team of Physicians at the University of Pennsylvania’s School of Medicine now has their project of modifying the immune cells of 18 different cancer patients with the CRISPR-Cas9 system approved by the National Institute of Health.

CRISPR is the gift that keeps on giving—when it’s not fighting blindness, tackling HIV, or even recording real-time immune responses, it is taking on the emperor of all maladies: cancer.

But what’s even more fascinating about this use of CRISPR is that the National Institute of Health’s (NIH) Recombinant DNA Research Advisory Committee (RAC) has approved the first-ever use of CRISPR in human cancer therapy, a monumental step in the history of the gene-editing technology.

Jun 22
2016

Italian Paleontologist Turns to Materialise to Help 3D Print Trilobite Fossils

Who needs cloning or gene editing; when you have 3D printers.

Although—in the grand scheme of things—3D printing is a relatively new technology in the eyes of humanity, that certainly doesn’t mean that it can’t be used to recreate some of the most ancient artifacts and fossils scattered throughout the Earth. Over the past year, we’ve seen 3D printing technology help recreate the oldest chameleon fossil ever found, as well as a 1220-foot Titanosaur fossil. Even some of the world’s tiniest fossils have been digitally resized and 3D printed so that a paleontologist from the University of Oxford could better examine them. Now, trilobites, which are a group of extinct marine arthropods, are undergoing their own unique form of 3D printed treatment.

Dr. Gianpaolo Di Silvestro, established paleontologist and CEO of the Italian company Trilobite Design Italia, specializes in this group of extinct arthropods, and uses his company to sell both original trilobite fossils and model replicas to collectors, institutions, and museums across the globe. After realizing that a great number of museums were able to provide text information on these fossils, but not a true physical representation, Dr. Di Silvestro decided to provide these museums with palpable trilobite models that would allow visitors to actually hold the ancient past in the palms of their hands. Since traditional fossil casting and modeling proved to be much too costly and time-consuming, Dr. Di Silvestro instead collaborated with Italian architect and 3D designer Francesco Baldassare to work in tandem and design accurate 3D models of trilobites.

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Although a number of 3D printing service bureaus rejected Dr. Di Silvestro’s 3D fossil models due to their design complexity, the Materialise office in Italy rose to the occasion and helped bring these trilobites back to our physical reality. For Dr. Di Silvestro and Baldassare, Materialise’s 3D printing technology has provided them with the ideal solution.

Jun 22
2016

A federal panel just gave the green light to use gene editing on humans

Scientists are one step closer to using CRISPR gene editing on humans, with a US federal advisory panel approving the use of the technique for a study led by the University of Pennsylvania.

The scientists are seeking to use the CRISPR-Cas9 technique to create genetically altered T cells – white blood cells that play an important role in our immune system – that are more effective at fighting cancer cells in patients with melanoma, multiple myeloma, and sarcoma.

“Our preliminary data suggests that we could improve the efficacy of these T cells if we use CRISPR,” lead researcher Carl June told the National Institute of Health’s (NIH) Recombinant DNA Advisory Committee (RAC) on Tuesday.

Jun 20
2016

Money Behind First CRISPR Test? It’s from Internet Billionaire Sean Parker

A next wave of cancer treatments may combine immunotherapy and gene editing.

Jun 19
2016

Genetically enhancing our children could raise interest rates

Always a trickle down effect on things that improve or change. Just reconfirms and reminds us organically how everything is indeed connected.

Capital tends to have greater value the more skilled and educated the workforce. Anticipating genetically enhanced workers would cause firms to want to invest more now in new equipment and buildings. Many assets, such as real estate and intellectual property, become more valuable the richer a society and so expectations of a much higher economic growth rate would cause companies to spend more buying and developing these assets so that businesses, as well as governments, will wish to borrow more when they realize the potential of human genetic engineering.

Many individuals will reduce their savings rate in anticipation of a future richer society. Today, fear that Social Security won’t survive motivates many Americans to save, but this fear and so this incentive for saving would disappear once genetic engineering for intelligence proves feasible. Furthermore, many citizens would rationally expect future government benefits to senior citizens to increase in a world made richer by genetic engineering and this expectation would reduce the perceived need to save for retirement.

Since understanding the consequences of a smarter workforce will increase the desire to borrow but reduce the wish to save, real interest rates will have to go up. These higher rates will reduce incentives to borrow while increasing the willingness to save and so will restore equilibrium to money markets. Expect to see higher interest rates as soon as markets price in embryo selection and genetic engineering.

Jun 18
2016

First Human Test of CRISPR Proposed

Doctors at the University of Pennsylvania seek approval for gene editing to fight cancer.

Jun 15
2016

SynBio Advances on Multiple Fronts

List of the who’s who are leading some of key bio programs around nextgen bio/ living cell technologies.

According to GEN’s experts, synthetic biology isn’t yet plug-and-play, but cellular processes are being engineered into biosensing systems as well as biologics production. Soon, for tasks from theranostics to regenerative medicine, “there will be a synbio app for that.”

Jun 10
2016

Living Bacteria Can Now Store Data

Using the CRISPR gene-editing tool, scientists from Harvard University have developed a technique that permanently records data into living cells. Incredibly, the information imprinted onto these microorganisms can be passed down to the next generation.

CRISPR/Cas9 is turning into an incredibly versatile tool. The cheap and easy-to-use molecular editing system that burst onto the biotech scene only a few years ago is being used for a host of applications, including genetic engineering, RNA editing, disease modeling, and fighting retroviruses like HIV. And now, as described in a new Science paper, it can also be used to turn lowly microorganisms into veritable hard drives.

http://io9.gizmodo.com/5935415/why-dna-is-the-future-of-data-storage