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To read about all our work on solving protein folding, go to deepmind.com/AlphaFold or read a timeline of the breakthrough here.

It’s been one year since we released and open sourced AlphaFold, our AI system to predict the 3D structure of a protein just from its 1D amino acid sequence, and created the AlphaFold Protein Structure Database (AlphaFold DB) to freely share this scientific knowledge with the world. Proteins are the building blocks of life, they underpin every biological process in every living thing. And, because a protein’s shape is closely linked with its function, knowing a protein’s structure unlocks a greater understanding of what it does and how it works. We hoped this groundbreaking resource would help accelerate scientific research and discovery globally, and that other teams could learn from and build on the advances we made with AlphaFold to create further breakthroughs. That hope has become a reality far quicker than we had dared to dream. Just twelve months later, AlphaFold has been accessed by more than half a million researchers and used to accelerate progress on important real-world problems ranging from plastic pollution to antibiotic resistance.

Today, I’m incredibly excited to share the next stage of this journey. In partnership with EMBL’s European Bioinformatics Institute (EMBL-EBI), we’re now releasing predicted structures for nearly all catalogued proteins known to science, which will expand the AlphaFold DB by over 200xfrom nearly 1 million structures to over 200 million structures - with the potential to dramatically increase our understanding of biology.

In late 2020, Alphabet’s DeepMind division unveiled its novel protein fold prediction algorithm, AlphaFold, and helped solve a scientific quandary that had stumped researchers for half a century. In the year since its beta release, half a million scientists from around the world have accessed the AI system’s results and cited them in their own studies more than 4,000 times. On Thursday, DeepMind announced that it is increasing that access even further by radically expanding its publicly-available AlphaFold Protein Structure Database (AlphaFoldDB) — from 1 million entries to 200 million entries.

Alphabet partnered with EMBL’s European Bioinformatics Institute (EMBL-EBI) for this undertaking, which covers proteins from across the kingdoms of life — animal, plant, fungi, bacteria and others. The results can be viewed on the UniProt, Ensembl, and OpenTargets websites or downloaded individually via GitHub, “for the human proteome and for the proteomes of 47 other key organisms important in research and global health,” per the AlphaFold website.

“AlphaFold is the singular and momentous advance in life science that demonstrates the power of AI,” Eric Topol, Founder and Director of the Scripps Research Translational Institute, siad in a press statement Thursday. “Determining the 3D structure of a protein used to take many months or years, it now takes seconds. AlphaFold has already accelerated and enabled massive discoveries, including cracking the structure of the nuclear pore complex. And with this new addition of structures illuminating nearly the entire protein universe, we can expect more biological mysteries to be solved each day.”

-Chapters
0:00 Kardashev scale.
1:55 Level.
03:11 Level 1 (planetary civilization)
4:48 Level 2 (stellar civilization)
6:38 Level 3 (galactic civilization)
8:09 Level 4 (universal civilization)
9:55 Level 5 (multiversal civilization)
11:15 Level 6 (multidimensional civilization)
12:26 Level 7 (creator civilization)

Email: [email protected].

#civilization.
#universe.
#Kardashev scale.
#type 1 civilization.
#type 2 civilization.
#type 3 civilization.
#type 4 civilization.
#type 5 civilization.
#type 6 civilization.
#type 7 civilization.

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Why we need AI to compete against each other. Does a Great Filter Stop all Alien Civilizations at some point? Are we Doomed if We Find Life in Our Solar System?

David Brin is a scientist, speaker, technical consultant and world-known author. His novels have been New York Times Bestsellers, winning multiple Hugo, Nebula and other awards.
A 1998 movie, directed by Kevin Costner, was loosely based on his book The Postman.
His Ph.D in Physics from UCSD — followed a masters in optics and an undergraduate degree in astrophysics from Caltech. He was a postdoctoral fellow at the California Space Institute and the Jet Propulsion Laboratory.
Brin serves on advisory committees dealing with subjects as diverse as national defense and homeland security, astronomy and space exploration, SETI and nanotechnology, future/prediction and philanthropy. He has served since 2010 on the council of external advisers for NASA’s Innovative and Advanced Concepts group (NIAC), which supports the most inventive and potentially ground-breaking new endeavors.

https://www.davidbrin.com/books.html.
https://twitter.com/DavidBrin.
https://www.newsweek.com/soon-humanity-wont-alone-universe-opinion-1717446

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Are we alone?


We are two scientists who study exoplanets and astrobiology. Thanks in large part to next-generation telescopes like Webb, researchers like us will soon be able to measure the chemical makeup of atmospheres of planets around other stars. The hope is that one or more of these planets will have a chemical signature of life.

Life might exist in the Solar System where there is liquid water — like the subsurface aquifers on Mars or in the oceans of Jupiter’s moon Europa. However, searching for life in these places is incredibly difficult, as they are hard to reach, and detecting life would require sending a probe to return physical samples.

Many astronomers believe there’s a good chance that life exists on planets orbiting other stars, and it’s possible that’s where life will first be found.

Scientists recently discovered thousands of ancient unknown bacteria lurking in Hawaii’s lava caves and geothermal vents.


Hawai’i is home to multiple lava caves, lava tubes, and geothermal vents. And a new study that researchers published in Frontiers in Microbiology reveals that these caves have higher bacteria diversity than expected. Researchers have discovered thousands of ancient unknown bacteria lurking within the caves.

Scientists say that these bacteria ecosystems represent how life might have existed during Earth’s early ages. They also say it could give us insight into how life on Mars looked before losing much of its atmosphere. The caves, home to lava tubes and geothermal vents on the island, house ancient unknown bacteria, unlike anything we’ve ever seen.

“This study points to the possibility that more ancient lineages of bacteria, like the phylum Chloroflexi, may have important ecological ‘jobs,’ or roles,” Dr. Rebecca D. Prescott, first author of the paper, said in a statement. The bacteria is so intriguing that some scientists have started calling it “microbial dark matter,” because of how unseen and un-studied it is.

An international team of researchers has discovered 1.2-billion-year-old groundwater deep in a gold-and uranium-producing mine in Moab Khotsong, South Africa, shedding more light on how life is sustained below the Earth’s surface and how it may thrive on other planets.

The findings were published earlier this week in the journal Nature Communications.

“For the first time, we have insight into how energy stored deep in the Earth’s subsurface can be released and distributed more broadly through its crust over time,” says Oliver Warr, research associate in the Department of Earth Sciences at the University of Toronto and lead author of the study. “Think of it as a Pandora’s Box of -and-hydrogen-producing power, one that we can learn how to harness for the benefit of the deep biosphere on a global scale.”

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The Fermi Paradox contemplates the weirdness of our galaxy seemingly being devoid of intelligent alien life, but Many Worlds Theory, Multiverses, Parallel Universe, and Alternate Realities may radically alter our thinking on Aliens & SETI.

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