Jan 2, 2025
Sleep microstructure organizes memory replay
Posted by Cecile G. Tamura in category: neuroscience
How sleep microstructure organizes memory replay.
T occur in isolation; older memories are also replayed during sleep, raising an intriguing challenge: how does the brain avoid interference between fragile new memories and stable old ones?” + To explore this question, researchers developed a groundbreaking method to study both hippocampal activity and sleep dynamics simultaneously in naturally sleeping mice. Using a technique called pupillometry, which measures oscillatory changes in pupil size, they uncovered a previously unknown “microstructure” within non-REM sleep that helps the brain manage memory replay.
They discovered that memory replay is organized into distinct substates of non-REM sleep:
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