Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associated secretory phenotype (SASP) factors. We aim to overcome this by a combination approach in which senescent cell burden is reduced utilizing SenoVax™ a dendritic cell based senolytic immunotherapy combined with syngeneic pluripotent stem cell derived MSC.
We induced hepatic injury and accelerated aging using two established murine models: carbon tetrachloride (CCl₄) mediated liver injury and doxorubicin induced systemic senescence. Animals were treated with control, SenoVax, pMSCs or the combination. Outcomes included biochemical and histologic indices of liver injury, circulating and tissue biomarkers of senescence (IL-11, YKL-40, IL-6, IL-23 R) and regeneration (Klotho, FGF-2, neo-VEGF, GDF-11).
Both CCl₄ and doxorubicin induced a robust senescent phenotype characterized by increased pro-inflammatory and pro-fibrotic mediators and downregulation of regenerative biomarkers. Combined senolytic and pMSC therapy outperformed mono therapies and produced clear synergistic benefits, including significant biochemical improvement of liver failure parameters, reversal of accelerated aging features, and restoration of regenerative signaling pathways. Senolytic monotherapy yielded partial improvements, while pMSCs alone showed limited activity in the presence of a high senescent-cell burden.
Lim et al. identify neutrophil-derived itaconate as a key environmental factor shaping tiered inflammatory responses in ALI. Itaconate metabolically promotes KDM5B-associated epigenetic activation of proinflammatory genes in alveolar macrophages, coordinating later-stage immune cell infiltration, including monocytes and T cells.
Northwestern scientists have developed a novel wireless sensor device that can continuously monitor skin elasticity in patients with soft tissue disorders, including lymphedema and scleroderma, which can support early disease detection and better inform care strategies, as detailed in a study published in Science Advances.
The sensor, which is directly applied to the patient’s skin, can measure a patient’s tissue elasticity and then wirelessly transmit critical disease-progression data, enabling a health care provider to remotely access that data from the patient’s home and potentially eliminating the need for an in-person clinical examination.
“The great thing about the sensor is it’s small, the potential for home use is tremendous, and for patients who know that they are at risk and know that they need to be constantly monitoring and detecting, this could give them a really good home-based unit that could potentially communicate data directly to their physician. That’s our goal,” said Ann Marie Flores, PT, MSPT, MA, Ph.D., CLT, FAPTA, associate professor of Physical Therapy and Human Movement Sciences and of Medical Social Sciences in the Division of Implementation Science, who was a co-corresponding author of the study.
When people hear the word \.
Fifteen years ago, I sat down with the father of virtual reality, and he told me the Singularity was a religion for geeks.
I disagreed with him. To his face.
Jaron Lanier was no technophobe. He built the tech. He just refused to worship it. In 2011, that made him an outlier. Everyone in my orbit was mapping exponential curves and setting dates for digital immortality.
Now look at the culture around #AI.
We have prophets and prophecies, heretics and true believers, people who genuinely expect a machine god to arrive and solve death, meaning, and the economy on our behalf. Lanier saw the shape of that faith before most of us would admit it was a faith at all.
I still think he was wrong about parts of it. I also think he was early on the part that matters most: technology is the How. It was never going to answer the Why or the What. That is the work a religion does, and for a lot of brilliant people the #Singularity quietly became exactly that.
The most severe droughts in the ancient Eastern Mediterranean arose when multiple natural climate cycles coincided, according to a new study from Stockholm University published in Science Advances. The findings shed new light on the climate conditions surrounding the Late Bronze Age collapse and may help improve understanding of future drought risks in a warming world.
“Rather than being caused by a single climatic event, we found that the most extreme droughts emerged when natural climate cycles operating over different timescales coincided. This helps explain why the droughts associated with the Late Bronze Age collapse were so severe,” said Katherine Power, a doctoral student in the Department of Physical Geography at Stockholm University and the study’s first author.