NIH scientists and collaborators reveal the brain preserves its representation of lost limb in clinical study.
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Reproducing Rejuvenation: Inside the Pig Plasma Longevity Experiments
Could pig plasma fractions really rejuvenate aging rats? Join me as I interview Nicolás and Nina from the Rejuvenation Science Institute (Brazil), who are working to reproduce the headline-creating “pig plasma rejuvenation” results. We explore the origins, science, controversies, challenges, and hopes surrounding this research—plus their plans for the next breakthrough longevity experiment and open science collaboration.
https://www.rejuvenescimento.org/english.
https://www.rejuvenescimento.org/news… https://journals.tmkarpinski.com/inde… Timestamps 00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate 02:00 – Origins: Why try to reproduce these results? 08:30 – What is being injected? Fraction preparation explained 15:40 – Acute toxicity and safety results: did the rats survive? 26:00 – The next experiment: timelines, scale-up, and open science goals Find me on Twitter — / eleanorsheekey Support the channel through PayPal — https://paypal.me/sheekeyscience?coun… through Patreon —
/ thesheekeyscienceshow Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; “https://www.freepik.com/free-photos-v…Background“Background vector created by freepik — www.freepik.com.
https://journals.tmkarpinski.com/inde…
Timestamps.
00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate.
02:00 – Origins: Why try to reproduce these results?
08:30 – What is being injected? Fraction preparation explained.
15:40 – Acute toxicity and safety results: did the rats survive?
26:00 – The next experiment: timelines, scale-up, and open science goals.
Find me on Twitter — / eleanorsheekey.
Support the channel.
through PayPal — https://paypal.me/sheekeyscience?coun…
through Patreon — / thesheekeyscienceshow.
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey’s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; \.
Pairing food waste and nanocatalysts to reduce carbon emissions in aviation
For researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign, a new avenue for reducing carbon emissions can be found on the side. A side of salad dressing, that is.
In 2020, the United States federal government committed to achieving net-zero carbon emissions by 2050. An important step toward carbon neutrality is embracing sustainable aviation fuel (SAF), an alternative to conventional jet fuel that is made from renewable feedstocks. As part of this initiative, Grainger engineers have been hard at work creating the critical nanocatalysts for converting biocrude oil from food waste such as salad dressing into sustainable aviation fuel.
Hong Yang, a professor of chemical & biomolecular engineering, and Yuanhui Zhang, a professor of agricultural & biological engineering, joined forces to tackle this problem.
Dusty structure explains near vanishing of faraway star
Stars die and vanish from sight all the time, but astronomers were puzzled when one that had been stable for more than a decade almost disappeared for eight months.
Between late 2024 and early 2025, one star in our galaxy, dubbed ASASSN-24fw, dimmed in brightness by about 97%, before brightening again. Since then, scientists have been swapping theories about what was behind this rare, exciting event.
Now, an international team led by scientists at The Ohio State University may have come up with an answer to the mystery. In a new study recently published in The Open Journal of Astrophysics, astronomers suggest that because the color of the star’s light remained unchanged during its dimming, the event wasn’t caused by the star evolving in some way, but by a large cloud of dust and gas around the star that occluded Earth’s view of it.
Why did MIT find 95% of AI projects fail? Hint: it wasn’t about the tech itself
The research was less about what’s wrong with today’s AI models and more about what’s wrong with how companies are trying to use them
Immunotherapy drug eliminates aggressive cancers in clinical trial
Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise—and induced great disappointment. While effective at activating the immune system to kill cancer cells in animal models, the drugs had limited impact on patients in clinical trials and caused dangerously systemic inflammatory responses, low platelet counts, and liver toxicity, among other adverse reactions—even at a low dose.
But in 2018, the lab of Rockefeller University’s Jeffrey V. Ravetch demonstrated it could engineer an enhanced CD40 agonist antibody so that it improved its efficacy and could be administered in a manner to limit serious side effects. The findings came from research on mice, genetically engineered to mimic the pathways relevant in humans. The next step was to have a clinical trial to see the drug’s impact on cancer patients.
Now the results from the phase 1 clinical trial of the drug, dubbed 2141-V11, have been published in Cancer Cell. Of 12 patients, six patients saw their tumors shrink, including two who saw them disappear completely.
The researchers demonstrate that an engineered antibody improves a class of drugs that has struggled to make good on its early promise.