
Diabetes has no well-established cure; thus, its management is critical for avoiding severe health complications involving multiple organs. This requires frequent glycaemia monitoring, and the gold standards for this are fingerstick tests. During the last decades, several blood-withdrawal-free platforms have been being studied to replace this test and to improve significantly the quality of life of people with diabetes (PWD). Devices estimating glycaemia level targeting blood or biofluids such as tears, saliva, breath and sweat, are gaining attention; however, most are not reliable, user-friendly and/or cheap. Given the complexity of the topic and the rise of diabetes, a careful analysis is essential to track scientific and industrial progresses in developing diabetes management systems. Here, we summarize the emerging blood glucose level (BGL) measurement methods and report some examples of devices which have been under development in the last decades, discussing the reasons for them not reaching the market or not being really non-invasive and continuous. After discussing more in depth the history of Raman spectroscopy-based researches and devices for BGL measurements, we will examine if this technique could have the potential for the development of a user-friendly, miniaturized, non-invasive and continuous blood glucose-monitoring device, which can operate reliably, without inter-patient variability, over sustained periods.
Diabetes is a lifelong disease that affects more than 400 millions of people worldwide (WHO. Diabetes, 2022). Emerging reports from the International Diabetes Federation state that diabetes is set to rise very fast, estimating 700 millions of cases in the next 25 years (IDF Diabetes Atlas, 2019). Among the various types of diabetes, all characterized by high blood glucose levels, the main two types are type 1 diabetes, an autoimmune condition where the pancreas produces little or no insulin, and type 2 diabetes, a metabolic disorder that results in hyperglycaemia due to insulin resistance. Diabetes, and related risk factors such as microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular metabolic disorders, is so widespread that it has been defined “the epidemic of the century” (Kharroubi, 2015).