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Single drug provides first evidence of ‘nearly universal’ pharmacological chaperone for rare disease

A study published in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single drug, already licensed for medical use, can stabilize nearly all mutated versions of a human protein, regardless of where the mutation is in the sequence.

The researchers engineered seven thousand versions of the vasopressin V2 receptor (V2R), which is critical for normal kidney function, creating all possible mutated variants in the lab.

Faulty mutations in V2R prevent from responding to the hormone vasopressin, leading to the inability to concentrate urine and resulting in excessive thirst and large volumes of dilute urine, causing nephrogenic diabetes insipidus (NDI), also known as arginine vasopressin resistance, a rare disease affecting roughly one in 25,000 people.

Stem Cells Repair Brain Damage Caused by Stroke in Mice

Brain damage caused by blocked blood vessels may be treatable using injections of stem cells, according to a new study by researchers from the University of Zurich and the University of Southern California.

The results could one day help patients who have experienced some forms of stroke recover lost functions.

Using mice with stroke-induced brain damage, the researchers found that injections of human stem cells could successfully develop into immature brain cells. The results were dramatic: most of the implanted cells remained in place, developing features of fully functioning neurons and communicating with surrounding cells.

Rare-earth tritellurides reveal a hidden ferroaxial order of electronic origin

The discovery of “hidden orders,” organization patterns in materials that cannot be detected using conventional measurement tools, can yield valuable insight, which can in turn support the design of new materials with advantageous properties and characteristics. The hidden orders that condensed matter physicists hope to uncover lie within so-called charge density waves (CDWs).

CDWs are periodic wave-like modulations of the electronic charge inside a crystal. CDWs in rare-earth tellurides, compounds containing tellurium and other rare-earth elements, have been found to sometimes give rise to unusual physical phenomena that are not observed in the absence of these wave-like states of matter.

Researchers at Boston College, Cornell University and other institutes recently observed a ferroaxial order in rare-earth tellurides that appears to originate from a combination of coupled orbital and charge patterns.

Robotaxi Wars Just Got BLOODY

Waymo’s partnership with Lyft in Nashville highlights advancements in robo-taxi safety, but the company faces significant challenges from Tesla’s established infrastructure and competitive landscape in the rapidly evolving autonomous vehicle market ## Questions to inspire discussion.

Tesla’s Robotaxi Advantage.

🚗 Q: How does Tesla’s manufacturing efficiency give it an edge in the robotaxi market? A: Tesla can build cars for one-third the price of competitors, with built-in Shepherds and the ability to manufacture at cost for FSD or robotaxi network use.

🌐 Q: What makes Tesla’s global expansion strategy unique? A: Tesla’s global approach and rapid execution allow it to go anywhere once FSD works, making it difficult for competitors to match its scale and speed.

🧠 Q: How significant is Tesla’s Full Self-Driving (FSD) technology? A: Tesla’s FSD is a gigantic advantage, with take rates tripling to double digits and expected to triple again, making it hard for others to compete.

Waymo’s Progress and Challenges.

Continue reading “Robotaxi Wars Just Got BLOODY” | >

A mobile robot scientist capable of carrying out experiments by itself

We live in a time when robots can clean our homes, drive our vehicles, deactivate bombs, offer prosthetic limbs, help healthcare workers, read the news, entertain, teach, and many more. And now, there is a robot scientist that can work on behalf of humans 24 hours a day, seven days a week.

Researchers at the University of Liverpool have built an intelligent “robot scientist” capable of moving around a laboratory and carrying out scientific experiments by itself. The first of its kind machine with humanoid dimensions are designed to work in a standard laboratory, using instruments much as a human researcher does. It can also make its own decisions about which chemistry experiments to perform next.

The robot scientist is 1.75-meter tall, weighs around 400 kg, and can roam around the laboratory, performing a wide range of different tasks. Unlike a human being, the robot has infinite patience, can think in 10 dimensions, and works for 21.5 hours each day, pausing only to recharge its battery for two hours. This will allow scientists to automate time-consuming and tedious research they wouldn’t otherwise tackle.

Life on Mars? NASA discovers potential biosignatures in Martian mudstones

Data and images from NASA’s Mars Perseverance rover reveals that recently discovered rocks in Jezero crater are organic carbon bearing mudstones. The findings, detailed in a paper published in Nature, indicate that these mudstones experienced chemical processes that left behind colorful, enigmatic textures in the rock that represent potential biosignatures.

The paper, led by Joel Hurowitz, PhD, Associate Professor in the Department of Geosciences at Stony Brook University, builds upon ongoing research conducted with the rover since it landed in 2021 – work aimed at characterizing early Martian geological processes and collecting samples that may someday be returned to Earth.

Upon entering the Jezero crater’s western edge, Perseverance investigated distinctive mudstone outcrops of the Bright Angel formation. There, the Mars 2020 science team conducted a detailed geological, petrographic, and geochemical survey of these rocks and found traces of carbon matter along with minerals, namely ferrous iron phosphate and iron sulfide.

Should We Sleep Outside? Turns Out There Are Some Benefits

A 2018 review became the first meta-analysis to quantify the impact of what they termed “greenspace exposure”. It sifted through five online databases leading up to January 2017 to look at the health outcomes of exposure to the great outdoors and found that “green prescriptions” could have substantial benefits to human health.

Perks mentioned included decreased salivary cortisol (the “stress hormone”), lower heart rate, blood pressure, and cholesterol, among others.

“Incidence of stroke, hypertension, dyslipidaemia, asthma, and coronary heart disease were reduced,” wrote the authors. “For several non-pooled health outcomes, between 66.7% and 100% of studies showed health-denoting associations with increased greenspace exposure, including neurological and cancer-related outcomes, and respiratory mortality.”

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