The Fairbairn Menstruation Science Fund will advance groundbreaking research at MIT on the function of the human uterus and its impact on sex-based differences in human immunology that contribute to gynecological disorders such as endometriosis, as well as other chronic systemic inflammatory diseases that disproportionately affect women, such as Lyme disease and lupus.
Despite significant advances in aging research, translating these findings into clinical practice remains a challenge. Aging is a complex, multifactorial process shaped by many factors including genetic, metabolic, and environmental factors. While medical advancements have extended lifespan, healthspan remains constrained by cellular senescence, telomere attrition, and systemic inflammation—core hallmarks of biological aging. However, emerging evidence suggests that telomere dynamic is not inevitable but can be influenced by oxidative stress, lifestyle choices, and metabolic regulation. This review examines how telomere-based biomarkers and metabolic interventions can drive personalized longevity medicine, enabling targeted strategies to delay aging.
A surprising new study has uncovered over 200 misfolded proteins in the brains of aging rats with cognitive decline, beyond the infamous amyloid and tau plaques long blamed for Alzheimer’s. These shape-shifting proteins don’t clump into visible plaques, making them harder to detect but potentially just as harmful. Scientists believe these “stealth” molecules could evade the brain’s cleanup systems and quietly impair memory and brain function. The discovery opens a new frontier in understanding dementia and could lead to entirely new targets for treatment and prevention.
Recent studies have already used Rydberg vapors to detect radio‑frequency fields with extreme sensitivity.
Persistent, phase‑locked oscillations promise low‑phase‑noise signals useful for clock recovery, precision spectroscopy, and perhaps gravitational‑wave detection, where any self‑referencing oscillator could serve as a phase tag.
On the theory side, researchers now have a platform for mapping phase diagrams that include stationary, bistable, and time‑crystalline regimes.
Beyond Space-Time and Quantum Mechanics.
Nima Arkani-Hamed.
(June 28, 2025)
A tribute to jim simons in celebration of the importance of basic science and mathematics.
Leaders in mathematics, science and philanthropy gathered on June 27, 2025, to remember the incredible contributions of Jim Simons and to inspire continued philanthropic support of basic research.
In a cosmic first, scientists watched planet-forming materials begin to solidify around a newborn star, offering a peek into what our Solar System may have looked like at birth. It’s a stunning replay of planetary evolution, just 1300 light-years away.
This Review summarizes the current knowledge on mortality-defining toxicities of chimeric antigen receptor T cell therapies beyond cytokine-release syndrome and immune effector cell-associated neurotoxicity syndrome. The authors discuss underlying mechanisms and how these affect timing and management, and outline key unmet needs and future priorities.
