What are the potential health risks from airborne dust pollution, especially in the growing threat of climate change? This is what a recent study published | Earth And The Environment
How can current international laws help prevent future wars in outer space? This is what a recent study published in the Leiden Journal of International La | Space
Blue zones, places home to an unusual number of centenarians, are looked to for their secrets to living healthier lives – but are they even real?
For industrial organizations serious about AI value, objective functions can provide the critical link between technical capabilities and business outcomes.
A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity.
A tiny, soft, flexible robot that can crawl through earthquake rubble to find trapped victims or travel inside the human body to deliver medicine may seem like science fiction, but an international team led by researchers at Penn State are pioneering such adaptable robots by integrating flexible electronics with magnetically controlled motion.
Researchers have succeeded, for the first time, in displaying three-dimensional graphics in mid-air that can be manipulated with the hands. The team includes Doctor Elodie Bouzbib, from Public University of Navarra (UPNA), together with Iosune Sarasate, Unai Fernández, Manuel López-Amo, Iván Fernández, Iñigo Ezcurdia and Asier Marzo (the latter two, members of the Institute of Smart Cities).
“What we see in films and call holograms are typically volumetric displays,” says Bouzbib, the first author of the work. “These are graphics that appear in mid-air and can be viewed from various angles without the need for wearing virtual reality glasses. They are called true-3D graphics.
They are particularly interesting as they allow for the ‘come-and-interact’ paradigm, meaning that the users simply approach a device and start using it.
Viruses infecting bacteria (bacteriophages) represent the most abundant viral particles in the human body. They participate in the control of the human-associated bacterial communities and play an important role in the dissemination of virulence genes. Here, we present the identification of a new filamentous single-stranded DNA phage of the family Inoviridae, named Ralstonia Inoviridae Phage 1 (RIP1), in the human blood. Metagenomics and PCR analyses detected the RIP1 genome in blood serum, in the absence of concomitant bacterial infection or contamination, suggesting inovirus persistence in the human blood. Finally, we have experimentally demonstrated that the RIP1-encoded rolling circle replication initiation protein and serine integrase have functional nuclear localization signals and upon expression in eukaryotic cells both proteins were translocated into the nucleus. This observation adds to the growing body of data suggesting that phages could have an overlooked impact on the evolution of eukaryotic cells.
Aquino et al. find that kinesin-driven transport of mitochondria toward the center of a C. elegans oocyte is sufficient to drive movement of the meiotic spindle in the opposite direction to the periphery of the oocyte.
Immune evasion of human stem-cell-derived neural graft in rodent models.
Transplantation rejection is the main challenge in human pluripotent stem cell (hPSC)-derived therapies.
The researchers used hPSC line (termed H1-FS-8IM), engineered to overexpress 8 immunomodulatory transgenes, to enable transplant immune evasion.
They show in co-cultures, H1-FS-8IM PSC-derived midbrain neurons evaded rejection by T lymphocytes, natural killer cells, macrophages, and dendritic cells.
The authors also provide preclinical evidence of pluripotent stem cell line evading immune detection after neural engraftment in a humanized immune system mouse model and reversal of motor symptoms in Parkinsonian rats.
Incorporation of a suicide gene within the universal donor cell ensures safety for cell-based therapies. https://sciencemission.com/A-cloaked-human-stem-cell-derived-neural-graft