Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.
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The James Webb Space Telescope has revealed ancient galaxies that appear far too massive and mature for their age, challenging our current understanding of cosmic evolution. These galaxies, observed just 330 million years after the Big Bang, should be small and irregular. Instead, they are well-formed and massive, suggesting that something fundamental about our models of the early universe may be incomplete.
One radical theory proposes that our universe could be the interior of a black hole in a larger parent universe. In this model, the Big Bang was not an explosion in empty space but the moment matter collapsed into a black hole, creating a new cosmos inside. The event horizon of this black hole would act as a boundary, beyond which everything—including time—behaves differently from an outside perspective.
Recent observations also suggest that the universe might have a preferred axis, contradicting the assumption that the cosmos is isotropic. The surprising alignment of galaxies on a large scale hints at unknown forces or structures shaping the universe. If true, this could support the idea that our universe is not an isolated system but is influenced by a larger framework, possibly the structure of a black hole’s interior.
Some theories also suggest that black holes could generate new universes through a process called a “big bounce,” where extreme torsion at high densities prevents a singularity from forming. Instead of collapsing to an infinitely small point, matter could rebound, triggering expansion. If our universe formed in such a way, it could explain why physical constants seem fine-tuned for life—because only stable, self-sustaining black hole universes would persist.
This docu-series covers all three of Earth’s next landing options – Asteroids, the Moon and Mars. The programmes explore the scientific reasons for and against each celestial body’s case to be the next that humans might colonise. They explore the technical and logistical problems and benefits of each – EG temperature at night and day, ability or inability to harness solar power and more.
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An AI scanning billions of particle collisions at CERN’s Large Hadron Collider has detected something extraordinary — a mysterious particle decay at 4.8 TeV that doesn’t match any known physics. While scientists aren’t calling it official yet, this anomaly could be our first glimpse of a fifth fundamental force of nature.
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The real AI discovery behind the viral headlines.
How machine learning found what human scientists missed.
Why this 2.9-sigma anomaly has top physicists watching closely.
The miracle of life. A 40-week process where you developed from a single cell to fully formed human baby. All within in your mother’s womb. Now, imagine you were born in an artifical womb. How would we benefit from artificial wombs? What would be the downsides?
Transcript and sources: https://whatif.show/what-if-we-could–… our Patreon community and help make What If better: http://bit.ly/whatif-patreon Watch more what-if scenarios: Planet Earth: • What If Earth Was in Fact Flat? The Cosmos:
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Iceland approved the 4-day workweek in 2019, nearly 6 years later, all the predictions made by Generation Z have come true
Posted in business, economics, law, singularity | Leave a Comment on Iceland approved the 4-day workweek in 2019, nearly 6 years later, all the predictions made by Generation Z have come true
Fewer hours. Same pay. Possible approach to the Economic Singularity?
In 2019, Iceland made headlines by becoming one of the first countries in the world to adopt the four-day working week, not through a general law, but through agreements allowing workers to negotiate shorter weeks or reduced hours. Five years on, the results are indisputable.
The Icelandic experiment began in 2015 with a pilot phase involving around 2,500 employees, or just over 1% of the country’s working population. Following the resounding success of this initiative, with 86% of the employees involved expressing their support, the project was formalised in 2019. Today, almost 90% of Icelandic workers benefit from a reduced working week of 36 hours, compared with 40 hours previously, with no loss of pay.
Initial concerns about the four-day week were widespread, both in Iceland and elsewhere in the world. There were fears of a drop in productivity, increased costs for businesses and difficulties in adapting to maintain service levels. However, the Icelandic experience has swept these fears under the carpet.
The moon’s nearside (that is, the side facing Earth) is dark-colored and dominated by ancient lava flows, whereas the farside is more rugged—and NASA researchers now suggest it’s due to a wonky lunar interior. Using data from twin spacecraft named Ebb and Flow, they found a 2–3% difference in the moon mantle’s ability to deform on each side. They say this data could be explained by the nearest hemisphere’s insides being up to 170°C hotter than the farside.
The detection of differences between the moon’s interior in the near and far hemispheres is reported in Nature this week.
The United States on Friday approved the first blood test for Alzheimer’s, a move that could help patients begin treatment earlier with newly approved drugs that slow the progression of the devastating neurological disease.
The test, developed by Fujirebio Diagnostics, measures the ratio of two proteins in the blood. The ratio is correlated with amyloid plaques in the brain—a hallmark of Alzheimer’s that, until now, has been detected only through brain scans or spinal fluid analysis.
“Alzheimer’s disease impacts too many people—more than breast cancer and prostate cancer combined,” said Food and Drug Administration Commissioner Marty Makary.
In a world racing towards electrification—from cars to villages—one thing remains crucial: affordabl
In patients with an advanced type of skin cancer called cutaneous squamous cell carcinoma (cSCC), those who received the combination of the immunotherapy drug avelumab and targeted agent cetuximab had almost four times longer median progression-free survival compared to patients who received avelumab alone, according to the results of a phase 2 trial presented today at the American Society of Clinical Oncology (ASCO) meeting and concurrently published in the Journal of Clinical Oncology.
“It is both an honor and humbling to develop clinical trials that can be potential options for our patients,” said lead author and study chair for the trial, Dan Zandberg, M.D., associate professor of medicine at the University of Pittsburgh and medical oncology co-leader of the head and neck cancer program at UPMC Hillman Cancer Center. “My hope is that the insights we made with this trial will lead to additional studies that can ultimately bring a new immunotherapy-based combination into standard of care for patients with advanced cSCC.”
CSCC is a common type of skin cancer with about 1.8 million cases diagnosed in the U.S. each year. About 95% of cSCCs are detected early and can be treated with minor surgery. But in rare cases, patients will go on to develop advanced cSCC, which includes locally advanced tumors that cannot be surgically removed and metastatic disease. At this point, the prognosis is poor and treatment is focused on extending survival, not cure.