How can moonquakes influence the locations of future human settlements on the Moon’s surface? This is what a recent study published in Science Advanc | Space
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Cardiac resident macrophages in cardiovascular disease: from physiology to pathology
Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal environmental homeostasis and repair after injury. Cardiac resident macrophages have been shown to regulate a variety of myocardial physiology and pathological activities. Homeostatic resident macrophages in the heart promote angiogenesis, remove ageing and dying cells and participate in cardiac electrical conduction. However, the role of cardiac resident macrophages is still not fully understood despite the growing attention they have received. This review provides an overview of macrophage biology and highlights prominent and emerging interrelationships and functions between cardiac resident macrophages and CVD, aiming to prove a description of the functional diversity of cardiac resident macrophages in different CVD to explore potential options to regulate them. This may provide opportunities for successful therapeutic interventions to improve the prognosis of patients with CVD.
Experiments add to evidence of links between amyloid deposits in brain and bone marrow
A recent study led by a team of researchers at The Johns Hopkins University School of Medicine examining aging mice has provided what is believed to be the first evidence that amyloid beta protein—small, sticky protein fragment found in people with Alzheimer’s disease (AD)—particles build up in the bone marrow of the animals, although not in the exact same form as the large, dense plaques found in the brains of people with Alzheimer’s disease.
“Although amyloid buildup has been found in organs outside the brain—such as the heart, kidneys, and nerves—it remains unclear whether similar deposits form in bone or bone marrow with aging or in Alzheimer’s disease,” says contributing study author Mei Wan, Ph.D., professor of the department of Orthopedic Surgery.
“While brain amyloid has been extensively studied for its role in memory loss and neurodegeneration, far less is known about amyloid elsewhere in the body. In fact, almost nothing is known about whether amyloid forms in the skeleton or how it might contribute to age-related bone loss.”
Study reveals wild chimpanzees learn how to communicate from relatives on mom’s side, not dad’s
Young chimpanzees learn their communication style from their mother and maternal relatives, but show little similarity to the communication behavior of their father and paternal relatives, according to a study published in the open-access journal PLOS Biology by Joseph Mine at the University of Zurich, Switzerland, and colleagues.
The Future of Science Lies BEYOND Materialism | Two AIs Discuss Podcast #199
The hosts delve into “The Future of Science” (Будущее Науки) by Viktor Filaletov (Виктор Филалетов), offering a profound exploration of science’s fundamental nature, evolving methodology, and crucial future prospects. The sources consistently portray science as a systematic process of knowledge acquisition, driven by the meticulous study of regularities and an unwavering commitment to understanding reality. At its core, scientific activity involves rigorous observation, precise experimentation, and the development of robust theories through the generalization of observations and facts. This entire scientific work is depicted as a deeply intellectual activity, fueled by intellectual curiosity and the unyielding pursuit of objective truth.
A significant focus is placed on scientific methodology, highlighting the importance of systematic research, the interplay of logic and intuition, and precise data analysis in tackling diverse scientific problems and achieving groundbreaking scientific discoveries. Scientific progress is depicted as a continuous, dynamic process, requiring constant critical thinking, scientific skepticism, and an openness to challenge established theoretical frameworks for ongoing intellectual development. The text distinguishes between fundamental research and applied research, acknowledging the vital role of both in advancing knowledge and understanding the world.
The sources candidly address the inherent challenges in scientific research, including navigating uncertainty in science and confronting the inherent limits of human understanding and perception. They underscore the vital human element, where scientific thought and scientific creativity are integral to the investigative process. Furthermore, crucial ethical considerations and profound scientific responsibility are discussed, particularly regarding the immense societal impact of science and its implications for future generations. The relentless pursuit of scientific truth often necessitates confronting the unknown and achieving scientific validation through empirical evidence. The text also touches upon the philosophical aspects of science and the importance of scientific integrity in all endeavors.
Looking towards the future of science, the discourse emphasizes relentless innovation and accelerated technological advancement. A compelling and recurring theme is the necessity of interdisciplinary research and expanded global scientific collaboration to effectively address and solve complex global challenges. The ongoing evolution of scientific thought and collective intellectual development are posited as essential drivers for uncovering new scientific breakthroughs and pushing the very frontiers of knowledge. Ultimately, scientific inquiry is presented as an unending pursuit of understanding, continually redefining our comprehension of the world and ensuring the future of scientific endeavor remains vibrant and impactful. #science #philosophy #FutureOfScience #ScientificResearch #ScienceProgress #KnowledgeDiscovery #HumanityForward #deepdive #skeptic #podcast #synopsis #books #bookreview #science #aiart #ai #artificialintelligence #booktube #aigenerated #videoessay
More scientific papers being written with help of ChatGPT—especially in computer science
Since its release in November of 2022, the use of ChatGPT and other large language models (LLMs) has proliferated throughout many disciplines, providing writing assistance for everything from speeches to contracts. So, it may not be surprising that some scientists might utilize ChatGPT to quicken the pace at which they publish their research.
Neoadjuvant vs Adjuvant Immunotherapy in Stage III Colon Cancer
Adjuvant immunotherapy plus chemotherapy has yet to square off against neoadjuvant immunotherapy in a head-to-head trial. Even if that trial doesn’t happen, post hoc analyses of ATOMIC and the neoadjuvant NICHE-2 studies may clarify whether a one-size-fits-all approach is appropriate and help determine which patients benefit more from one approach over the other, according to Christopher Lieu, MD, an investigator in the ATOMIC study.
The ATOMIC study showed that adding adjuvant immunotherapy to standard-of-care chemotherapy following resection reduced the risk for disease recurrence or death by 50% compared with chemotherapy alone in the 355 patients with stage III colon cancer with mismatch repair deficiency (dMMR), who received adjuvant atezolizumab along with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy, providing those in the pro-adjuvant camp with important data. In addition, 3-year disease-free survival (DFS) was 86.4% with the combination compared with 76.6% with chemotherapy alone. The results of this trial were presented at the American Society of Clinical Oncology (ASCO) 2025.
Experts debate which patients with stage III dMMR colon cancer will benefit from the two treatment approaches.
2025 UP.Partners Moving World Report
Emerging technologies, such as autonomous vehicles, drones, and humanoid robotics, are rapidly transforming industries and revolutionizing transportation, logistics, and other sectors, driven by decreasing costs, economic incentives, and significant investments.
Questions to inspire discussion.
Emerging Technologies 🚁 Q: How are drones revolutionizing delivery services? A: Drones are delivering millions of goods with insane energy efficiency, cost-effectiveness, and convenience, exemplified by Google’s Wing program partnering with Walmart and DoorDash, and Zipline saving half a million lives delivering medicine worldwide. 🤖 Q: What roles can humanoid robots fill in the workforce?
