University of Cincinnati structural biologists are the first in the world to visualize a key cell protein as part of newly published research from the College of Medicine. The Seegar Lab has become the first to visualize the structure of a regulator protein, iRhom1, bound to the ADAM17 enzyme, using cryogenic electron microscopy housed in UC’s Center for Advanced Structural Biology research facility.

This follows the lab’s work published last year that visualized the structure of ADAM17 bound to iRhom2.

ADAM17 enzyme activity is essential in humans for proper tissue development and immune response, and regulating its activity is a drug target in treating chronic inflammatory diseases. Ectodomain shedding is the fundamental biological process in which enzymes, such as ADAM17, rapidly cleave and release other protein targets from the cell surface, altering cell-to-cell communication.