Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the DNA is wrapped around a core of histone proteins and tightly packed into so-called nucleosomes.

So that the genetic material can be reliably copied, the chromatin has to be temporarily reorganized in certain places and adopt a very specific architecture.

A team led by molecular biologists Professor Axel Imhof and Professor Christoph Kurat at the Biomedical Center (BMC) has now deciphered how the precise packaging of DNA is controlled at the beginning of cell division. The work is published in the journal Nature Communications.